Pages: 1

Author Topic: 2-fluoroamphetamine, good starting precursor?  (Read 224 times)

Naphyrone

  • Pupae
  • **
  • Posts: 62
2-fluoroamphetamine, good starting precursor?
« on: September 02, 2010, 09:51:30 PM »
So 2-fluoroamphetamine has caught my interest since apparently it is very smooth with less of the side effects than regular amphetamine and more of a functional stimulant than a euphoric recreational one. The reduced side effects compared to regular amphetamine is a major plus because i tend to experience the cholinergic effects of amphetamine quite strongly(intense dry mouth). Anyways 2-fluorobenzaldehyde is expensive stuff, was wondering if there is a better precursor that is cheaper and the more OTC the better. I don't mind taking a few extra steps to get to the end result. Any documents on the stuff would be appreciated too.

Naphyrone

  • Pupae
  • **
  • Posts: 62
Re: 2-fluoroamphetamine, good starting precursor?
« Reply #1 on: September 03, 2010, 04:35:24 AM »
I'm a bit drunk at the moment but iv'e been thinking about this subject matter all day.
What if you chlorinated sec-butanol then oxidized the alcohol and did a fidel-crafts on fluorobenzene?
Would this even work right? I see ending up with an end result of various fluoro positions.

elverano

  • Larvae
  • *
  • Posts: 2
Re: 2-fluoroamphetamine, good starting precursor?
« Reply #2 on: September 20, 2010, 05:12:19 PM »
Toluene + Chlorine + Catalysis = Monochlorotoluenes

Monochlorotoluenes + distillation = 2-chlorotoluene

2-chlorotoluene + Halex = 2-fluorotoluene

2-fluorotoluene + Manganous-ammonium alum (see sciencemadness.org) = 2-fluorobenzaldehyde

Ta-fucking-da!!

Vesp

  • Administrator
  • Foundress Queen
  • *****
  • Posts: 3,130
Re: 2-fluoroamphetamine, good starting precursor?
« Reply #3 on: September 20, 2010, 08:51:48 PM »
Halex?

How easy and at what yield would the 2-chlorotoluene form?

What catalyst is used for the chlorine toluination? It seems like perhaps you could get a chloro or bromobenzene and reflux that with some 1,3,5-trimethylbenzene or xylene to form the wanted chlorotoluene *possibly* in better yield than the direct reaction with toluene and Cl2, or Br2... perhaps I am wrong, but it would seem like benzyl chloride is the most common product.
Bitcoin address: 1FVrHdXJBr6Z9uhtiQKy4g7c7yHtGKjyLy

Buzzoff

  • Larvae
  • *
  • Posts: 15
Re: 2-fluoroamphetamine, good starting precursor?
« Reply #4 on: September 20, 2010, 11:27:38 PM »
Well, for many years, the structurally related 2-Methoxy-Methamphetamine was available OTC.

Might still actually be legal.  Took a fairly large dose to be effective, but hey, it was cheap and legal.

I'm assuming that you will never do it, or that the reaction could be impossible.  But, the synthesis of  2-Fluoro-toluene, might possibly be achieved, by the diazotization of o-methylaniline, conversion to the fluoroborate salt, then followed by thermal decomposition of the complex salt to fluorotoluene.  The procedure for producing Fluorobenzene by this method, is outlined in the fifth edition of Vogel's "Practical Organic Chemistry".

Similar to this procedure, from Organic Synthesis.

http://www.orgsyn.org/orgsyn/orgsyn/prepcontent.asp?prep=cv2p0295
« Last Edit: September 20, 2010, 11:40:24 PM by Buzzoff »

jon

  • Foundress Queen
  • *****
  • Posts: 1,883
Re: 2-fluoroamphetamine, good starting precursor?
« Reply #5 on: September 20, 2010, 11:54:26 PM »
i hear p-nitromethamphetamine is good very warm more relaxed too.
it's ld 50 is between meth and mda something like 65mg/kg
so it's more dangerous than mdma.
and it's not hard to make either.

the above procedure looks dangerous too i think just stick with what's possible.
« Last Edit: September 20, 2010, 11:55:59 PM by jon »

Buzzoff

  • Larvae
  • *
  • Posts: 15
Re: 2-fluoroamphetamine, good starting precursor?
« Reply #6 on: September 21, 2010, 04:47:17 AM »
Well, I'm not recommending it, but it looks possible.

Clearly, some research should be embarked upon before attempting such a synthesis.

Discovering first hand, that the toluel diazonium fluoroborate, was much less stable than the benzene diazonium fluoroborate.......Might cause a fella to become un-incarnated.

The germane question regarding fluoro-benzaldehyde should be......"How do folks usually do it?"

jon

  • Foundress Queen
  • *****
  • Posts: 1,883
Re: 2-fluoroamphetamine, good starting precursor?
« Reply #7 on: September 21, 2010, 03:49:15 PM »
those compounds are toxic and expolsion hazards i don't think it's very safe the term "shock sensitive" comes to mind

Vesp

  • Administrator
  • Foundress Queen
  • *****
  • Posts: 3,130
Re: 2-fluoroamphetamine, good starting precursor?
« Reply #8 on: September 21, 2010, 08:13:30 PM »
Quote
The germane question regarding fluoro-benzaldehyde should be......"How do folks usually do it?"

I agree, so what are some of the current and previous industrial methods of producing flouro-aromatics?
Bitcoin address: 1FVrHdXJBr6Z9uhtiQKy4g7c7yHtGKjyLy

Buzzoff

  • Larvae
  • *
  • Posts: 15
Re: 2-fluoroamphetamine, good starting precursor?
« Reply #9 on: September 22, 2010, 01:51:11 AM »
As you know, the usual instruction for isolating benzenediazonium salts is "DON'T".

For whatever reasons, the Fluoroborate Salts, are considered fairly stable.  That I have seen such procedures written-up in Organic Synthesis, Vogel, and in other places.....Without extensive cautions, suggests that the level of peril might not be extreme.

Would I run the reaction?  Maybe.  There would have to be a pretty big payoff though.  Fluoro toluene wouldn't qualify. 
Pages: 1