we all know that ergonovine is psychedelic causing closed eye visuals (spinning geometry, etc.) as experienced by bigwood and friends decades ago at the 10mg level....it's just that at that dosage, while it is quite psychedelic, the cramping it induces in the leg muscles is debilitating to the point of being painful, and even preventing walking....Hofmann even had closed eye visuals at the 2mg level and after that theorized that indeed it was ergonovine that was the sacred drink used at eleusis.
so a theory i've been pondering and which would be an even easier synthesis (to the point of practical) would be to do a cold water extraction on claviceps purpurea, as it contains large amounts of water soluble ergonovine (ergometrine) and only trace amounts of lsa, then take the cold water solution full of ergonovine and spin it with acetaldehyde and alcohol and water to "adduct" an acetaldehyde molecule on to the indole-nitrogen of ergonovine, that may just then give you nearly the exact same thing as sansert, which is proven to cause profound lsd-like effects at the 20mg dosage, some people on line found 20mg of sansert (5 of the pills) to be indistinguishable from real lsd. the methyl group on the indole-nitrogen of sansert reduces the vasoconstriction considerably so that large doses of it can be taken without vasoconstricitive side effects, yet the psychedelic effects are left intact.....i have a theory that the same thing may happen with ergonovine when an acetaldehyde is adducted onto the indole-nitrogen, turning it into something that is still psychedelic, but with less anxiety, stronger psychedelic effects, and with less vasoconstriction, but that's a whole nother topic. Jonathan ott said that 20mg of sansert is equivalent to about 100 ug of lsd. this could have been the famous sacred brew prepared for the ceremony at eleusis, the priest just doing a cold water extract on claviceps purpurea, then adding in mint with alcohol and water (then mix it or let it sit for a day) to adduct the two different aldehydes in mint onto the indole-nitrogen of ergonovine. this would in theory all be best done in a dark fridge with a portable battery powered magnetic stirrer spinning overnight.
what we need to know is how a methyl group CH3 compares with an acetyldehyde group CH3CHO at the indole-nitrogen position, will the CH3CHO group significantly reduce vasoconstriction as well as CH3 ?
acetyldehyde = CH3CHO
isobutyraldehyde = (CH3)2CHCHO
isovaleraldehyde = (CH3)2CHCH2CHO
remember, ALD-52 has the following acetyl-group at the indole-nitrogen = COCH3
White bread = 0.0225% isobutyraldehyde
Beer = 0.005% isobutyraldehyde
Apple juice = 0.000002% isobutyraldehyde
peppermint = 0.04% isobutyraldehyde
Peppermint oil has about 0.04% isobutyraldehyde and 0.19% isovaleraldehyde
anyhow, back on topic...
The table from Sandoz suggested that ALD might actually have advantages over LSD, reducing any side effects but achieving a stronger trip. Measurements of brain waves while people were taking the two drugs showed that while LSD produced brain waves associated with intense concentration and anxiety, ALD produced brain waves showing a more relaxed mental state. It is possible ALD-52 was the active chemical in the "Orange Sunshine" LSD that was widely available in California through 1968 and 1969.