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Author Topic: Codeine to Hérone  (Read 264 times)

NaBH4

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Re: Codeine to Hérone
« Reply #20 on: October 14, 2010, 06:19:26 PM »

Sorry, I haz a sad  :D


So, seriously, Jon, I'm probably very wrong but you were categoric and that, sometimes, very frustrating to talk with you.

Anyway, frenchs are crazy and the trains are totally blocked. I won't have time for asking my teacher. Too bad, free holidays ^_^
"All simple monkeys with alien babies, amphetamines for boys, crucifixes for ladies ...."

jon

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Re: Codeine to Hérone
« Reply #21 on: October 14, 2010, 06:47:50 PM »
no problem i just don't like disinformation.
if what your saying is true i'd love to see that verified.
i've read an account of someone trying exactly this and failing and he's an undergraduate chem student so i don't think it was poor technique.
he said it would'nt crystallize it just oiled out but no qualitative analysis was done.
if you can perform a qualitative expiriminet preferably thin layer chromatagraphy with standard values to compare against.
it would confirm the validity or invalidity of this method.

solidstone

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Re: Codeine to Hérone
« Reply #22 on: October 15, 2010, 11:58:12 PM »
It appears from the literature that oxidation with dichromate of codeine will not yield 14-hydroxy codeinone.
 It yields codeinone. Codeinone can be converted to 14-hydroxycodeinone with the addition of hydrogen peroxide and formic acid.


(pg 6[0047])google.com/patents?hl=en&lr=&vid=USPATAPP9793024&id=T8mbAAAAEBAJ&oi=fnd&dq=oxycodone+dichromate&printsec=abstract#v=onepage&q=oxycodone%20dichromate&f=false

This method is cited in essential drug synthesis, however it is only briefly mentioned and oversimplified.
As Jon mentioned the direct oxidation in acetic acid is mentioned for Thebaine in all the literature.  Perhaps you did it the right way but failed to communicate that.  regardless your initial post was misleading in making the procedure look far simpler then it is.

In Oxy by Otto Snow (pg40), he cites an ancient german paper.  The title is confusing but it confirms codeinone and sodium dicromate OR thebaine and sodium dichromate in acetic acid.
« Last Edit: October 16, 2010, 12:04:14 AM by solidstone »
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