Hey everybee. Just found this forum, and I hope I can learn a lot from it. Cheers.
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Tungsten.
- Larvae
- Posts: 44
Vesp
- Administrator
- Foundress Queen
- Posts: 3,130
Hope you can as well! Let me know what you think of it once you get done checking it out and seeing what we're all about.
Also - what are your main interests? Chemistry or does it mix with biology, etc?
Also - what are your main interests? Chemistry or does it mix with biology, etc?
xxxxx
- Larvae
- Posts: 8
Welcome, I hope you find this community as friendly and informative as I have!
Tungsten.
- Larvae
- Posts: 44
I am mainly into the chemistry side of things. However I am sort of new to the whole chemistry of phenylethylamines and I am a complete virgin in the world of tryptamines. I am less interested in the biochemistry side of things, but I have been known to dabble in LSD, Salvia, and psilocybin mushrooms on occasion (I'm not quite sure which side you are approaching this from .)
One thing that truly interests me is the chemistry behind Salvinorin A. How is it that it can be so different looking from all other psychedelics, yet function in very much the same way? And are there other compounds like that could be even better that can be synthesized from it?
One thing that truly interests me is the chemistry behind Salvinorin A. How is it that it can be so different looking from all other psychedelics, yet function in very much the same way? And are there other compounds like that could be even better that can be synthesized from it?
Vesp
- Administrator
- Foundress Queen
- Posts: 3,130
A synthetic analogue of Salvinorin could be interesting.
I believe pharmacological view it is very different since it works via Kappa Opioid receptors IIRC?
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yet function in very much the same way?You mean psychologically?
I believe pharmacological view it is very different since it works via Kappa Opioid receptors IIRC?
Tungsten.
- Larvae
- Posts: 44
Yes, psychologically.
embezzler
- Subordinate Wasp
- Posts: 228
due to the large number of chiral centres in salvinorin A synthesis is very limited. I think there are 11 so a 2 to the power of 11 number of enantiomers with different activities usually none there are some 40 step low yielding syntheses out there....
Semi synthetic options may exist but would require isolation of the parent compound or something similar.
welcome in any case
selective kappa opoid agonist
Semi synthetic options may exist but would require isolation of the parent compound or something similar.
welcome in any case
selective kappa opoid agonist
Tungsten.
- Larvae
- Posts: 44
due to the large number of chiral centres in salvinorin A synthesis is very limited. I think there are 11 so a 2 to the power of 11 number of enantiomers with different activities usually none there are some 40 step low yielding syntheses out there....
Semi synthetic options may exist but would require isolation of the parent compound or something similar.
welcome in any case
selective kappa opoid agonist
That is very interesting. I had no idea that there was even a synthesis for the stuff, I guess I just assumed that it was such a big complex molecule that it would be impratical to even try.
What I'm talking about is changing the functional groups on the molecule (starting with the chemical extracted from the plant) ala dr shulgin.
embezzler
- Subordinate Wasp
- Posts: 228
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That is very interesting. I had no idea that there was even a synthesis for the stuff, I guess I just assumed that it was such a big complex molecule that it would be impratical to even try.I think this was accomplished because it was pointless and difficult. It is not an economically viable route to this, one of the most potent substances per weight.
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What I'm talking about is changing the functional groups on the molecule (starting with the chemical extracted from the plant) ala dr shulgin.
This is what was meant by the term semi-synthetic and by all means get involved in this.
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