"The obvious issue is that since nitration of 2-chloropropanoic acid would involve a secondary halide, it might prove difficult or impossible to do."
That is fine!
"Method 7: destructive distillation of alpha-bromopropionic acid with sodium nitrite
K2CO3 + NaNO2 + H2O + a-br-propionic acid ? nitroethane 50%yield
Add 20g of the acid to a solution of K2CO3 in the amount of base that causes the solution to be basic to phenolphthalein. The add 20g of NaNO2--there should be approx. 100ml of solution. Place in a 250ml rb flask and distill quickly- the first 100ml will come over before the rxn takes place. Then the nitroethane comes over. Distill until no more product comes over.(don't distill to dryness)
V. Auger. Bull. Soc. Chim. FrancePost no. 3, 23, 333 (1900) by the kolbe method."
"Method 17: Distillation of alpha-bromopropionic acids with NaNO2 in the presence of Magnesium Sulfate in DMSO
US pat # 4319059"
(the alpha-bromo acid can be obtained using propionic acid in the procedure from Org. Synth. CV 1, 115.)
http://www.designer-drugs.com/pte/12.162.180.114/dcd/chemistry/nitroethane.html
Well done!
That is fine!
"Method 7: destructive distillation of alpha-bromopropionic acid with sodium nitrite
K2CO3 + NaNO2 + H2O + a-br-propionic acid ? nitroethane 50%yield
Add 20g of the acid to a solution of K2CO3 in the amount of base that causes the solution to be basic to phenolphthalein. The add 20g of NaNO2--there should be approx. 100ml of solution. Place in a 250ml rb flask and distill quickly- the first 100ml will come over before the rxn takes place. Then the nitroethane comes over. Distill until no more product comes over.(don't distill to dryness)
V. Auger. Bull. Soc. Chim. FrancePost no. 3, 23, 333 (1900) by the kolbe method."
"Method 17: Distillation of alpha-bromopropionic acids with NaNO2 in the presence of Magnesium Sulfate in DMSO
US pat # 4319059"
(the alpha-bromo acid can be obtained using propionic acid in the procedure from Org. Synth. CV 1, 115.)
http://www.designer-drugs.com/pte/12.162.180.114/dcd/chemistry/nitroethane.html
Well done!