According to a fascinating book on fungal metabolites I've been perusing, this fungus Stereum Subpileatum which infests woods, like beer barrels, produces 5-methoxybenzofuran. That would be a nifty material to have I think.
Indole is easily made to condense with acrylate salts to the 3-indolepropionic acid, which can be precipitated as its calcium salt. Perhaps I'm wrong, but I think 5-methoxybenzofuran would behave similarly. Amide, Hofmann degradation, alkylation. Using methylamine outright to form the amide would save the trouble of (over)methylation, and then something bulky like isopropyl- would be less inclined to quaternise. Or, use methacrylic acid and spare the alkylation.
"Dimemebfe" according to Wikipedia "is several times less potent as a serotonin agonist than 5-MeO-DMT and with relatively more activity at 5-HT1A, but still shows strongest effects at the 5-HT2 family of receptors."
Do you guys think that fungal cultivation is a reasonable source for 5-MeO-BF or have any idea out to selectively increase its yield from the culture?
Indole is easily made to condense with acrylate salts to the 3-indolepropionic acid, which can be precipitated as its calcium salt. Perhaps I'm wrong, but I think 5-methoxybenzofuran would behave similarly. Amide, Hofmann degradation, alkylation. Using methylamine outright to form the amide would save the trouble of (over)methylation, and then something bulky like isopropyl- would be less inclined to quaternise. Or, use methacrylic acid and spare the alkylation.
"Dimemebfe" according to Wikipedia "is several times less potent as a serotonin agonist than 5-MeO-DMT and with relatively more activity at 5-HT1A, but still shows strongest effects at the 5-HT2 family of receptors."
Do you guys think that fungal cultivation is a reasonable source for 5-MeO-BF or have any idea out to selectively increase its yield from the culture?
VOLATILE METABOLIC PRODUCTS OF STEREUM SUBPILEATUM.pdf