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Author Topic: Expanded Bromosafrole Writeup  (Read 1686 times)

salat

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Re: Expanded Bromosafrole Writeup
« Reply #60 on: June 25, 2012, 05:09:37 PM »
I recall a thread in the hive archives where Rhodium advocated the triethylamine method.  The way Rhodium spoke about it sounded to me like an Aspie who has solved a problem and as a result is no longer interested in any other methods.

I did a quick search but can't find the thread right this moment and can't spend any more time on it.  I'm knee deep in packing lab glassware in hopes of finally moving.  Perhaps someone else knows the thread.

Salat

lugh

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Re: Expanded Bromosafrole Writeup
« Reply #61 on: June 25, 2012, 06:45:45 PM »
Chemistry is our Covalent Bond

Wizard X

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Re: Expanded Bromosafrole Writeup
« Reply #62 on: June 26, 2012, 06:01:50 AM »
Quote from: Sedit on June 25, 2012, 08:31:41 AM
Quote from: Wizard X on June 25, 2012, 12:55:38 AM
While triethylamine is commonly employed in organic synthesis as a base, and other applications, I would NOT consider it as a reagent to freebase methylamine.HCl

The cost, compared to NaOH or KOH and, the hazard (Explosive limits, exposure) isn't justified.

Its not about cost its about being able to free the methylamine without the creation of H2O.

Please read and understand Dissolution (chemistry). http://en.wikipedia.org/wiki/Dissolution_(chemistry)
Albert Einstein - "Great ideas often receive violent opposition from mediocre minds."

carl_nnabis

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Re: Expanded Bromosafrole Writeup
« Reply #63 on: June 26, 2012, 06:57:53 PM »
race fuel is avaible yes but mixed, i was talking about pure methanol. If there is something which really needs methanol, theres still these very expensive fuel cell energy storage thingys, that use methanol als hydrogen source, but you have to show up in person because methanol is like glacial acetic acid or hydroflouric acid not allowed to be sent through standard mail.
And really, when I would need some moew, i think i would simply drove to france or holland they have it as denatured alcohol pure instead ethanol like here ;D that would bee easier than to distill race car fuel ;D
there are many dozen other OTC alcohols so i dont care really ;D
they wont sell methanol pure only because its toxicity but i believe its more because of its use in biodiesel production.

anyway, you can use isopropyl alcohol in the sn2 halogen-amine swap, i do, it works good using 2-bromopropiophenone with methylamine, and this is essentially the same reaction there   
« Last Edit: June 26, 2012, 07:02:47 PM by carl_nnabis »
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jon

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Re: Expanded Bromosafrole Writeup
« Reply #64 on: June 26, 2012, 07:32:41 PM »
ipa is definitely the secret here

T-cowboy

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Re: Expanded Bromosafrole Writeup
« Reply #65 on: July 01, 2012, 06:24:25 PM »
Trieethylamine.hcl is not soluble in IPA (cold) Carl_nabbis..

Source: wikipedia ET3N, Own experience.

carl_nnabis

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Re: Expanded Bromosafrole Writeup
« Reply #66 on: July 01, 2012, 07:06:16 PM »
ok thx for the info it was new to me. but my opinion wont change, better make some cool nitroalcohol with it for norephedrine production ;D
"It's like the drug trip I saw when I was on that drug trip!"

jon

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Re: Expanded Bromosafrole Writeup
« Reply #67 on: July 02, 2012, 01:13:21 AM »
Quote
HI all!!!!
The last night i was dreaming about "the Jon method".
6 gr of oil was bad brominated, then the finkelstein swap was made and finally the iodo compound was aminated under Delepine.
The yield was so bad, but for the first time I product!!! 

i've gotten quite familiar with these reactions and some say the delepine can't work on a secondary halide but after much reading i found oone exception: isopropyl iodidies.
the reacction really takes a month to complete so this informational is just for shits and grins but it does work in this special case.

pbinteger

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Re: Expanded Bromosafrole Writeup
« Reply #68 on: September 18, 2012, 10:52:34 PM »
Salat

What specifically prevents one from using KI, GAA, & H2SO4 as reagents with Safrole to arrive at Iodosafrole. Why the extra step?
It is commonly known that one can arrive at Iodosafrole using NaI, and it would seem that the Iodide is all we're concerned with.

Polonium

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Re: Expanded Bromosafrole Writeup
« Reply #69 on: September 19, 2012, 12:42:52 PM »
I think bromine is used for halogenation due to the relatively expense of iodine salts. It is much cheaper to do the bromination first and then perform the almost quantitative halogen swap to form iodosafrole
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