I had been thinking about the current direction research psychedelics have been going in and to me there is not much body to them in terms of recreational use. I mean part of what makes many illegal drugs is that they are not highly selective to 1 receptor.
However from this standpoint how would you approach developing a chem to target several desired receptors?
Would you start with something that's highly selective of the receptor you wish to focus on or start with something dirty that hits most the receptors you want it to but a couple you don't and work on making that compound more selective?
Also what about compounds that are antagonist/inverse agonists to certain receptors and antagonist to others. I think many people would enjoy a psychedelic that while being a 5ht1a and 5ht2a agonist was also a 5ht2c inverse agonist.
To me this seems like a vast field that no one is tapping into, I mean sure there's a reason however imagine all the progress that could be made in understanding the human brain if research and development for recreation drugs was allowed. The potential for new boundaries of euphoria and money would definitely hold a torch to the ass of drug companies if they were allowed to develop recreational drugs.
With any luck though, computing power is getting cheap cheap cheap and I'm sure soon enough novel amateur recreational drug design/discover will start happening.
I think a good place to start even in terms of structure based that I recently noticed would be how the dragonfly compounds and amino tetralines align with the phenethylamine substructure in lsd. I think shulgin could have missed a potentially active methylenedioxy tryptamine specifically the 6,7 position. 5-meo-7-iodo-dmt might also be a good one to check out. I may upload some example images later after i get some rest to better demonstrate what i mean or you can just look at this...
(source, drugs-forum and vesp pointed me to this pic when discussing what i noticed)
However from this standpoint how would you approach developing a chem to target several desired receptors?
Would you start with something that's highly selective of the receptor you wish to focus on or start with something dirty that hits most the receptors you want it to but a couple you don't and work on making that compound more selective?
Also what about compounds that are antagonist/inverse agonists to certain receptors and antagonist to others. I think many people would enjoy a psychedelic that while being a 5ht1a and 5ht2a agonist was also a 5ht2c inverse agonist.
To me this seems like a vast field that no one is tapping into, I mean sure there's a reason however imagine all the progress that could be made in understanding the human brain if research and development for recreation drugs was allowed. The potential for new boundaries of euphoria and money would definitely hold a torch to the ass of drug companies if they were allowed to develop recreational drugs.
With any luck though, computing power is getting cheap cheap cheap and I'm sure soon enough novel amateur recreational drug design/discover will start happening.
I think a good place to start even in terms of structure based that I recently noticed would be how the dragonfly compounds and amino tetralines align with the phenethylamine substructure in lsd. I think shulgin could have missed a potentially active methylenedioxy tryptamine specifically the 6,7 position. 5-meo-7-iodo-dmt might also be a good one to check out. I may upload some example images later after i get some rest to better demonstrate what i mean or you can just look at this...
(source, drugs-forum and vesp pointed me to this pic when discussing what i noticed)