I think it's next to impossible to get it starting from MDA.

You can get 5-methoxy-MDA by aplying same method for safrole on myristicin.
I guess you will need "5-methyl-safrole" (or to be precise 5-methy-3,4-methylenedioxyphenyl-2-propene) to get desired compound by aminating it.

If you can get it for any suplier cheap than please tell us how!?
You think we didn't tried that?

You can vac. distill myristicin from certain types of parsley essential oil.

If you can get 3-methylcatechol, it's simple from there:

duff formylation
methylenation
Darzen condensation / nitroethane condensation / butanone aldol condensation / propionic anhydride aldol condensation
reductive amination / nitropropene reduction / Beckmann rearrangement / amidation + Hofmann rearrangement

The one clever way to 3-methylcatechol I know is via a Claisen on 2-allyloxyphenol, that being the product of mono-O-alkylation of catechol with allyl chloride / sodium carbonate. This gives 3-allylcatechol which undergoes alkene cleavage with KMnO4 to o-benzoquinone-3-yl-acetic acid, this being a beta keto acid which decarboxylates to give 3-methyl-benzoquinone, this easily reducing to 3-MC.

It's 5 times more powerful then regular MDA albiet without the stimulating affects. How would you synthesize it starting with MDA.


Add some references and show more research! -- vesp

Dr. David Nichols of Purdue, the world's foremost leading expert on psychedelics. He good enough source for you Vesp?

Quote from: Bardo on March 11, 2011, 03:44:41 AM

It's 5 times more powerful then regular MDA albiet without the stimulating affects. How would you synthesize it starting with MDA.



Add some references and show more research! -- vesp

Dr. David Nichols of Purdue, the world's foremost leading expert on psychedelics. He good enough source for you Vesp?

Nope! A name of a person and their title is not research or even a reference.

First off, this is the Drug Synthesis & Extraction forum - the rules are clearly stated in the the stickied RULES in the Site Matters section - In addition to being linked over 2000 times else where on the forum in my signature.

When making a new thread in Drug Synthesis & Extraction, Other Chemistry, and Pharmacology - and preferably others if applicable show that you have researched, and have searched here on the site by providing links and references of relevant information, or at least mention how you cannot find any detail related to the subject in which you are posting.

When you look at your first post, there are really only two parts to it...
1. It's 5 times more powerful then regular MDA albiet without the stimulating affects.
2. How would you synthesize it starting with MDA.

Given this is not the pharmacology forum the first point is off topic. The second point is simply asking how to make it - you have done no research, or even proposed ideas on how it might be done. you simply are asking to be spoon fed the answers, and having useful information be dumped in front of you.

I was going to leave this open - and I was hoping you were just going to edit your post and add some decent information or references - perhaps a paper or two by Dr. David Nichols of Purdue.. or even bring up this ridiculously easy to find and well indexed link: http://www.erowid.org/archive/rhodium/chemistry/5-methyl-mda.html


While this is in the Vacuous Posts, a decent 5-methyl-MDA thread is completely welcome.