So this what i've been working on lately. Im gonna have 0 time to pursue this in the following months so i defer to you guys for improvements/ results if any of you are interested.

I've been trying to improve twodogs method ( MDA synthesis from alpha-methyl-1,3-benzodioxole-5-propanal via Oxime and then Hoffman )  by using a one pot reaction that leads directly from alpha-methyl-1,3-benzodioxole-5-propanal to the corresponding Amide with fairly OTC chemicals.

Here are the references ( i believe you can even find them online) :   

1) J. Org. Chem. 2003, 68, 1158-1160

2) Tetrahedron Letters 42 (2001) 1103–1105  ( Pretty much the same thing )

For those of you who can't access this. Basically the reaction uses a nitrile intermediary. What you do is react alpha-methyl-1,3-benzodioxole-5-propanal  with Iodine in 27% Ammonia water for approx one hour ( no heat) then drop H2O2 slowly to the mixture and VOILA. Wash, extract with DCM and ideally you have the Amide.

Thats in theory. Now the fun part.

The only thing that bothered me in this write up was the use of THF as cosolvent with water and the use of 27% ammonia. I've been trying to find another cosolvent and use only 13 % Ammonia ( with the right adjustments to xxxxxxxx proportions)  to make this MEGA OTC but what this has been giving me is mostly crapola. The main issue being the I2 wasnt dissolving properly.

There you go. Give me your thoughts / improvements although i wont be able to put them into practice before late this summer..
It'd be great if some of you could run it but i guess thats just wishful thinking ^^

Cheers

well hello there

hahahah, but he used to download journal articles and it had the name of the uni he went to, so he got foxit pdf editor, which removed from most. Or is this some other

ohhh i feel much better my cornhole was getting really nervous you see.
thanks for easing my mind
an ass what a terrible thing to waste.

nah i got tricks up my sleave it's always at least 2 steps but i like mda sometimes
that's good stuff though not saying i'm unimpressed, i'm more into scale
keep that technology under your cap though don't post that kind of stuff everywhere i remember what it did for us back in the 90's
we don't want a repeat.
make them work for thier money.

edit that will ya?
no sources!!!
don't worry about xxxxxxxx just yet.
it might get you surveillence but so fucking what?
it's not list it can't mean probable cause means no grounds for search warrant.
they can follow you around all day and no they are'nt wearing suits they usually have a bit of a scruffy appearance there are caveats to spotting the dea.

just watch out for this guy

[youtube]http://www.youtube.com/watch?v=FKDlyjce-UM&feature=relmfu[/youtube]

Do you want to try a iodination of the hydroxyl and then adding the amine group with ammonia ? Why adding H2O2 ?

If the iodination works, i would then add methylamine.

This is just horrible off-topic. The Onion News network, and god knows what else doesn't belong in the "Main" sections of this site - let alone ones that I suggest have references, and others...

Try to stay on topic more... please?