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Author Topic: 3,5-Br-4-(MeO or Me)-phenethylamine?  (Read 90 times)

digemlo

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3,5-Br-4-(MeO or Me)-phenethylamine?
« on: April 25, 2011, 07:05:30 PM »
Hey all,

Anybody have any insight as to the activity of 3,5-Br (or I/Cl) -4-(MeO or Me)-phenethylamine?

Looks like it might be a decent mescaline replacement with a higher lipid solubility. The ethylamine tail of the molecule would allow it to still be degraded by MAO so toxicity may not be a high concern.

Enkidu

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Re: 3,5-Br-4-(MeO or Me)-phenethylamine?
« Reply #1 on: April 25, 2011, 08:02:41 PM »
IIRC, it isn't active. You need the methoxy at the 5 position at least for hydrogen bonding. Mescaline is already of rather low potency. BTW, you mean 3,5-dibromo. Ref/links?

pyramid

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Re: 3,5-Br-4-(MeO or Me)-phenethylamine?
« Reply #2 on: April 25, 2011, 09:56:07 PM »
You may have meant dibromo, but I will say that 3-bromo-5-ethoxy-4-methoxyphenethylamine has slight activity, 3-bromo-4-isopropoxy-5-methoxyphenethylamine has been made but has not been bioassayed so I cannot comment on activity there.
3-bromo-4,5-dimethoxyphenethylamine apparently has some activity but I have tried it and did not really notice an effect. May have been because of other PEA usage around the time, but none of these are worth making for the effects, only for lab experience.
Of course I'm not sure if these types of compounds are even what you are talking about..

digemlo

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Re: 3,5-Br-4-(MeO or Me)-phenethylamine?
« Reply #3 on: April 25, 2011, 11:14:12 PM »
Quote from: Enkidu on April 25, 2011, 08:02:41 PM
IIRC, it isn't active. You need the methoxy at the 5 position at least for hydrogen bonding. Mescaline is already of rather low potency. BTW, you mean 3,5-dibromo. Ref/links?
Ah, thanks, yeah, that should say dibromo-. There are no refs for the compounds mentioned AFAIK.

Quote from: pyramid on April 25, 2011, 09:56:07 PM
You may have meant dibromo, but I will say that 3-bromo-5-ethoxy-4-methoxyphenethylamine has slight activity, 3-bromo-4-isopropoxy-5-methoxyphenethylamine has been made but has not been bioassayed so I cannot comment on activity there.
3-bromo-4,5-dimethoxyphenethylamine apparently has some activity but I have tried it and did not really notice an effect. May have been because of other PEA usage around the time, but none of these are worth making for the effects, only for lab experience.
Of course I'm not sure if these types of compounds are even what you are talking about..

Thanks for the input. Any info on the masses of the substrates used in the lab experiments?
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