I would just buy the anthranilic acid if I wanted to go that route. I am suspicious to a degree actually of ludes...I suspect, just possibly, that it might be an AMPA agonist...which are NOT good things. I imagine propionyl chloride would work, instead of acetic anhydride, no Ac2O hanging about, but propionyl chloride, yes. Remember that nastiness when a phenyl ring-methylated derivative came round on the RC scene? methylmethaqualone? in some people, that did what they wanted, but at a little higher dose then it caused twitching of the fingers and hands, and hyperreflexia, in some cases near seizures, although I don't remember if anyone actually had a full blown seizure from the stuff MTQ itself causes seizures in overdose, indeed OD is treated with benzos in many cases due to hyperreflexive presentation and seizure. I believe that MTQ may well, nay, is likely to be, a low-efficacy competitive AMPA agonist, which whilst compensated for perhaps to a degree by the potent GABAa mediated inhibitory effects, orthosteric ionotropic glutamate receptor agonists are VERY bad news, being excitotoxic, in the case of AMPA-mediated toxicity, look up amnesic shellfish poisoning/domoic acid, and as a specific example of kainate receptor-mediated neurotoxicity, ever heard of acromelic acid? acromelic acids A, and B (which share a very disturbing similarity to stizolobic and stizolobinic acid found in Amanita Pantherina, the panther cap mushroom, a source of ibotenate, the NMDA agonist neurotoxin that is decarboxylated to muscimol by prolonged dry heating, stizolobic acid is a neurotoxin that is probably also kainate-selective, although due to different effects I believe possibly targeting a different KAR subtype, damn stuff is active at femtomolar concentrations
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The acromelic acids are found in certain fungi of the genus Tricholoma, T.acromelalga and T.amnoelens, and when eaten, cause a prolonged and very severe allodynia and hyperalgesia, along with oedema, typically in the extremities particularly, made worse by heat, and temporarily relieved by immersion in very cold water of the affected bodyparts. In some cases this has lasted for many years post ingestion. Again, highly potent by weight, no, in fact, extremely so.
As for the chlorbutol....
Actually, its starting to crystallize in the flask to a degree, I was out with friends last night so I couldn't finish the workup, but when I get round to it, dump out over ice, neutralize any NaOH remaining, and evap the remaining traces of chloroform and 'tone....mmm, I love the smell of chloroform...possibly because for some wierd reason, its still in medicinal use here in the UK to a tiny extent-present in an OTC codeine syrup (600mg/200ml codeine, chloroform in there as a preservative I think, but there is enough in there if its dissolved in a drink, that it will precipitate out in an oily blob on the bottom, adds to the taste, and makes it go really well with a mixture of cheap tesco own brand limeade and vodka)
The reason I made it, is because I got bored actually. When I get bored, things happen, and the labware comes out to play, doesn't matter if its anything useful, next one might be alpha-chloralose, either the making thereof, or lazy extraction from OTC rat poison.
Say....off topic, but hey, I posted it:P, anybody know how much patch-clamp equipment goes for second/third hand these days? there are certain things about alpha- and beta-chloralose I am curious about, I am interested to know if either have any affinity for the GHBr..
(You know you are a clandestine chemist when.....
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I was under the impression that chlorbutol was quite long acting, although not horrendously potent. Anybody know if the cyclohexanone-chloroform adduct would be active, in a similar way to ethynylcyclohexanol?
Rgardless of what can be expected from taking it, the synth is/was its own justification, I need no other.
