Author Topic: p-hydroxybenzoic acid from Aspirin  (Read 58 times)

no1uno

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p-hydroxybenzoic acid from Aspirin
« on: June 02, 2011, 11:34:48 PM »
A whole lot of bees/others have been busting their butts trying to work out a route to hydroquinone/benzoquinone from seriously OTC products, potentially as a decent source of the same for synthesis in the 2,5-series. I was slightly surprised, given the amount of work that has been done (and the research done by many including myself) to find this - p-Hydroxybenzoic Acid made by heating the dried potassium salicylate with potassium carbonate under CO2 (ie. the dipotassium salt - yield is supposedly near theoretical).

Form the methyl p-methoxybenzoate using pretty much any methylating agent, then work out a route to getting rid of that ester to give p-methoxyphenol as required by so many syntheses
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nk40ouvm

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Re: p-hydroxybenzoic acid from Aspirin
« Reply #1 on: June 03, 2011, 04:47:53 AM »
Nice find. And phenol as a byproduct too!