Researching this chem, i have come up with what i think looks like a viable method. If it is flawed, please speak up.
This method is as follows.
This is a carbamation in the presence of an alkyl Halide and cesium carbonate in DMF. This, in theory, run on Phenylalanine would return the molecule posted below.
As far as i am aware, The resulting molecule can be reduced directly to methamphetamine using Hydriodic acid (RP and Iodine) as though one was reducing ephidrine, as i believe hydriodic acid will strip the oxygens away leaving the carbon on carboxcylic acid functions, and in this case, the one on the nitrogen included, which is the carbamate.
The interesting thing, is that an alkyl halide is needed in the first step, the carbamation of the primary amine function. Obviously that would have to be methyl iodide. It just so happens that methyl iodide forms in situ upon the reaction of Red P and Iodine
Wikipedia quote.
It is sounds to me like the carbamation and reduction to methamphetamine can almost be done 1 pot. From what i can tell, no side reactions can occur here other than the ones intended, so long as the reagents were added in the right order. DMF and Methanol in some cases are interchangeable, meaning the whole thing may be able to run in DMF, OR methanol??
"In conclusion, we have developed a simple and efficient one-pot synthesis of various N-alkyl carbamates starting with primary amines using cesium carbonate. This reaction is compatible with a diverse range of amines and alkyl halides providing a general method to prepare functionalized carbamates in moderate to high yields."
What are your thoughts chem guys?
This method is as follows.
Quote
"A facile one-pot synthesis of N-alkyl carbamates is described. A primary amine, CO2, and an alkyl halide underwent a three-component coupling using cesium carbonate and tetrabutylammonium iodide (TBAI) giving rise to the resultant carbamate. In the presence of Cs2CO3, subsequent N-alkylation of the in situ generated carbamate with a different alkyl halide afforded various aliphatic N-alkyl carbamates, respectively.
Carbamation of primary amines was in situ followed by N-alkylation in the presence of cesium carbonate to afford the fully substituted carbamates."
This is a carbamation in the presence of an alkyl Halide and cesium carbonate in DMF. This, in theory, run on Phenylalanine would return the molecule posted below.
As far as i am aware, The resulting molecule can be reduced directly to methamphetamine using Hydriodic acid (RP and Iodine) as though one was reducing ephidrine, as i believe hydriodic acid will strip the oxygens away leaving the carbon on carboxcylic acid functions, and in this case, the one on the nitrogen included, which is the carbamate.
The interesting thing, is that an alkyl halide is needed in the first step, the carbamation of the primary amine function. Obviously that would have to be methyl iodide. It just so happens that methyl iodide forms in situ upon the reaction of Red P and Iodine
Wikipedia quote.
Quote
Methyl iodide is formed via the exothermic reaction that occurs when iodine is added to a mixture of methanol with red phosphorus.[4] The iodinating reagent is phosphorus triiodide that is formed in situ:
3 CH3OH + PI3 ? 3 CH3I + H3PO3
It is sounds to me like the carbamation and reduction to methamphetamine can almost be done 1 pot. From what i can tell, no side reactions can occur here other than the ones intended, so long as the reagents were added in the right order. DMF and Methanol in some cases are interchangeable, meaning the whole thing may be able to run in DMF, OR methanol??
"In conclusion, we have developed a simple and efficient one-pot synthesis of various N-alkyl carbamates starting with primary amines using cesium carbonate. This reaction is compatible with a diverse range of amines and alkyl halides providing a general method to prepare functionalized carbamates in moderate to high yields."
What are your thoughts chem guys?