Author Topic: What chemical is this? Way more powerful then LSD! (Read 490 times)

Vesp · « **on:** May 24, 2009, 09:12:36 PM »

While looking around on the web, trying to get a deeper understanding of how drugs act as agonists and antagonists, I found this interesting claim...

Quote

Recently, for example, we have “stumbled” upon a
simple phenethylamine molecule that has affinity for
the 5-HT2A receptor nearly 100-fold higher than any
other compound discovered to date, including LSD
itself!
Quote
-- http://www.heffter.org/review/chapter5.pdf

What interests me the most is that it is a simple phenethylamine, perhaps it wouldn't be hard to synthesize?

I've attached the PDF linked above, just in case the link above goes down.

I am afraid that this 100 fold compound may be something like bromo-dragon fly, or DOB. I think it is likely that these substances could be metabolized much faster, and allowing for only a little bit to reach the brain - so in the end you need to take a higher dose, despite it being 100 times more active.

I have not found any information on what other compounds this could be, and it wouldn't surprise me if it one we've never heard of, do you guys have any idea, or can you find any references on it?

zzhuchila_clocker · « **Reply #1 on:** May 25, 2009, 04:44:22 AM »

I know so-called BOMs are active at that doses. o-methoxybenzyl attached to nitrogen of PEAs increases their potency (in case of 2c-b, in 100 times). I'm sure there are some BOMs more active then LSD, but unfortunately all of them are metabolized if ingested (they can be smoked, injected etc)

Vesp · « **Reply #2 on:** May 25, 2009, 08:55:13 PM »

BOMs?
Do you mean DOB, DOM, or something like that?
if not, link to information on BOMs?

Sedit · « **Reply #3 on:** May 25, 2009, 10:12:16 PM »

Various FLY's
http://en.wikipedia.org/wiki/2C-B-FLY

This is the only compound I have any slight knowlage about and its known as BromoDragonFly: http://en.wikipedia.org/wiki/Bromo-DragonFLY
Extreamly Potant yet not very good for you because it can lead to vascular constriction to the extremities causing effects on the same level that one would get from a bad case of frostbite.

Vesp · « **Reply #4 on:** May 26, 2009, 02:13:50 AM »

yeah, but Bromo-dragonfly is said to be only slightly less potent then LSD.
I wonder what an easy way would be to make that stuff? It seems pretty interesting, I bet a hybrid between DOB and Bromo-dragonfly could have some nice qualities.

Enkidu · « **Reply #5 on:** May 26, 2009, 05:04:23 AM »

it's probably similar to this:

http://en.wikipedia.org/wiki/25I-NBOMe

http://www.bluelight.ru/vb/showpost.php?p=6398422&postcount=19

zzhuchila_clocker · « **Reply #6 on:** May 26, 2009, 07:21:55 PM »

yes, that is actually what i mean

Enkidu · « **Reply #7 on:** May 26, 2009, 08:48:45 PM »

Yeah, I was just clarifying for Vesp. Do you remember if those are partial agonists or full agonists? I know that I can look it up, but I'm lazy... $:-\$

Vesp · « **Reply #8 on:** May 27, 2009, 01:10:58 AM »

wow thanks for those links, I eventually found this page while looking at them, hopefully it will be of use to you guys.

http://en.wikipedia.org/wiki/Category:Psychedelic_phenethylamines

Sedit · « **Reply #9 on:** May 27, 2009, 03:26:23 AM »

Wow Im shocked that they have so many on Wiki.

Vesp · « **Reply #10 on:** May 27, 2009, 04:09:01 AM »

I am too, I wonder what one is the best and easiest to make all things considered? I'm guessing DOB.

Douchermann · « **Reply #11 on:** May 27, 2009, 07:22:58 AM »

Anyone notice that there was only 162(ish) phenethylamines listed but shulgin's book has 179 IIRC... infact his book (PiHKAL) is listed under P? I was unaware books were psychedelic... much just be paperbacks.

Vesp · « **Reply #12 on:** May 28, 2009, 04:50:31 AM »

I bet the DOX, or 2C-X analogues of 4-Methyl-aminorex or phenylpropanolamine could be pretty interesting, and it sounds like they would be easy to make.

cft · « **Reply #13 on:** June 01, 2009, 04:04:09 AM »

Dr Nichols has never reported any compound even approaching 100x the potency of LSD so it may just have been a figure of speech...on the other hand though he admits to not disclosing all the compounds they invent, apparantly he was quite upset when people died from the p-methylthioamphetamine his team invented, so you can understand why he might be reluctant with details of the strongest compounds!

The most potent compounds that have been disclosed in the public literature by his team would be things like bromo-dragonfly, NBOMe-2CI, TCB-2, TFMFly, NBOMe-2CB-FLY etc, but while all of those would probably be similar potency range to LSD I doubt any of them would be more than twice as potent at best, as high affinity does not mean high efficacy also. Bromodragonfly for instance has a lower Ki than LSD in the test tube but is only half the potency when you actually take it.

Read some of the PhD dissertations from Nichols students, there are a few compounds in there that have not been described in Nichols' articles in J Med Chem and so on. The most potent one listed in the Michael Braden dissertation from 2007 is called 25I-NBDHF which he does not give a structure for, but it is most likely the N-benzodihydrofuran-7-yl derivative of 2CI.

Vesp · « **Reply #14 on:** June 01, 2009, 05:32:17 AM »

I see, well thanks for that. I am sure the goverment is at least interesting in this 100xLSD compound. Does anyone have data on this 25I-NBDHF?
bit of info on it here: http://www.bluelight.ru/vb/showthread.php?t=388351

zzhuchila_clocker · « **Reply #15 on:** June 09, 2009, 07:28:34 PM »

Quote

Do you remember if those are partial agonists or full agonists? I know that I can look it up, but I'm lazy...

sorry, this i also don't know. pharmacology is my problematic field;)

jon · « **Reply #16 on:** November 04, 2009, 05:03:15 AM »

I bet the DOX, or 2C-X analogues of 4-Methyl-aminorex or phenylpropanolamine could be pretty interesting, and it sounds like they would be easy to make.

certain ring substuted variants have been made forget the sub pattern in general bioassays reveal they act more like antidepressants. were talking about methoxylated.
halogenated increases potency really don't want it.

swij made some 4- mar and damn near killed himself pale skin, eyes roll back in head, and seizures up to that point it was fun but don't do 100+ mg of it stuff is very dangerous i mean deadly.

Locked · « **Reply #17 on:** November 06, 2009, 03:31:38 AM »

Not to go way of topic, but...

Jon, do you use ld50s as a dosage guide? IronMan!

jon · « **Reply #18 on:** November 06, 2009, 03:46:45 AM »

not really when i dicked around with 4-mar i did'nt realize it was 4x meth and lowers seizure thersholds so easily until the flopping started it felt like a safe stimulant up to that point ie. no tachycardia just good euphoria.
after that flush flush say bye bye easier to get rid of something before it gets rid of you.
strongly discourage it's use, it's very sneaky it's easy to misjudge.
a colleague had played around with different methoxylated versions relayed to me very much like antidepressants.

Sedit · « **Reply #19 on:** November 06, 2009, 04:12:39 AM »

Jon I read your post for shock value at times.....

It takes 2-3 times to understand it....... but when I do.....

Author Topic: What chemical is this? Way more powerful then LSD! (Read 490 times)

Vesp

What chemical is this? Way more powerful then LSD!

zzhuchila_clocker

Re: What chemical is this? Way more powerful then LSD!

Vesp

Re: What chemical is this? Way more powerful then LSD!

Sedit

Re: What chemical is this? Way more powerful then LSD!

Vesp

Re: What chemical is this? Way more powerful then LSD!

Enkidu

Re: What chemical is this? Way more powerful then LSD!

zzhuchila_clocker

Re: What chemical is this? Way more powerful then LSD!

Enkidu

Re: What chemical is this? Way more powerful then LSD!

Vesp

Re: What chemical is this? Way more powerful then LSD!

Sedit

Re: What chemical is this? Way more powerful then LSD!

Vesp

Re: What chemical is this? Way more powerful then LSD!

Douchermann

Re: What chemical is this? Way more powerful then LSD!

Vesp

Re: What chemical is this? Way more powerful then LSD!

cft

Re: What chemical is this? Way more powerful then LSD!

Vesp

Re: What chemical is this? Way more powerful then LSD!

zzhuchila_clocker

Re: What chemical is this? Way more powerful then LSD!

jon

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Locked

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jon

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Sedit

Re: What chemical is this? Way more powerful then LSD!