Read up on this is will answer some of your questions.

http://en.wikipedia.org/wiki/Picamilon

Its similar to what your saying, GABA can not cross the BBB however here they formed and amide out of Niacine and GABA causing it to metabolize after crossing into the brain, into Niacin and GABA having mild sedative effects. I do not know the results of doing this on larger molecules but it takes time to metabolize such things normally making them loose some of there effectiveness in the process.

Forming a prodrug for both acid and mescaline would be a rediculous idea, I'm afraid.

The active dose of mescaline is at LEAST 250mg at the low end, as the hydrochloride. As the common sulfate salt, 500mg is a pretty respectable heavy dose. Just imagine how much LSD that would let loose. Quite possibly a lethal dose I would have thought, certainly a massive, psyche-shredding, soul obliterating dose that could well leave the user with PTSD afterwards.

But chimaera-like prodrugs (I refer to the mythical beast, not to the biological terminology) themselves are not bad ideas. a codeine/barbiturate salt has been done, dionine I think was the trade name, I think I've heard of some sort of prodrug dual release something or other, involving modafinil, and there are a few others out there.

Actually, 'ol toady has a bit of a project on the back burner of this nature himself. The idea, is to proceed through an isocyanate derived from 3,4-methylenedioxyphenylpropional, and react this with very, very, very carefully dried anhydrous alcohols, several will, when Tsathoggua eventually gets round to reacting his xxxxxxxx, be tested, the lead candidates are 2-methyl-butan-2-ol, and he shall have to synthesize also, some 1-ethynyl-cyclohexan-1-ol, the 1,1,1-trichloroethanol derivative sounds like it would be promising to try.

An isocyanate will react to the corresponding carbamate ester, and carbamates are often used as acid-labile protecting groups. The idea being, that in his country, the misuse of drugs act covers specific compounds, occasionally with rather poorly written attempts at catch-all clauses for fentanyls, some psychedelics etc, but does not have an analog act. So this will bypass ever possessing MDA (and the alcohols are themselves unscheduled), here, having a drug in one's body doesn't constitute a criminal offense, only possession or supply. Not only that, but to use an alcohol with a roughly equal potency, or at least, not much less potent, or if possible, more so by a bit, the result would be cleavage in the acidic environment of the stomach, to, for instance, chloral and MDA, relatively slowly compared to the instant availability of MDA itself as is, leading to a smooth, easy come-up, and the alcohol part of the prodrug taking the overstimulating edge off the MDxx and polishing it up a bit, making it nice and relaxing.

What the potential for acidic hydrolysis in the stomach is, depends entirely on what the prodrug is, I.e the nature of the bonding moiety, some, such as acyl esters will be reasonably prone to it, others, for instance, an ether would be less so, and some, such as your friendly(maybe) neighbourhood amphibious extradimensional demon lord's carbamate amphetamine prodrug series will actually bee entirely dependent upon such protonolytic cleavage.

Remember-for a prodrug to work, it MUST be decomposable, not nescessarily in the stomach, but it has to happen somewhere, or else it won't be a prodrug, but just a big bulky molecule that is two drugs stuck together, where they can't go ahead and bind to their respective receptors.

You want the two drugs to be taped or glued together, not welded.

You say peptide coupling techniques to circumvent precursor regulation has beecome more common? please do tell of this, Tsathoggua is most interested, given his proclivities here, he is under the impression, that his idea for coupling the *********-isocyanate with various highly potent alcohol GABA agonists is completely novel, not the idea of prodrugs, but this set in particular.

Its all about tweaking pharmacokinetics really, thats what everything boils down to (and of course, pulling one's fly down and waving one's cock in the eyes of the plod). Look up picamilon, as has been stated, and lysdexamphetamine for some background reading and inspiration. There are a fair few chloral hydrate prodrugs also, but these, like the parent drug are pretty antiquated, and I would be quite surprised if they are still in use.

Already mentioned that one.

No lethal limit? bollocks. Its simply that no sane dose will kill. If you snorted a coke-sized line of it, then chances are, IMO, you would be at risk of dying. There was a case where they tried dosing an elephant with LSD, and inadvertently gave the poor creature a lethal dose, if I remember right, it was in the region of 60mg, 66 perhaps.

It could be that elephants are specifically sensitive to it, but if thats enough to kill an elephant, then your prodrug idea, is not a good one. It requires that on a molar basis the drugs be of roughly equal potency.

So its a good bet, that if you took a mescaline-sized dose, you would be tripping for the rest of your life. So to speak......Take an acid-sized dose, and the mescaline will do nothing at all.

Yes, they would likely indeed last a lifetime.

My point was, that it would last a lifetime, owing to the person so dosed's lifetime, not being very long afterwards.

Perhaps my sense of humor was lost there. As for a clinical/legal setting...bollocks. And bollocks again, to that. Where exactly do you think you, or anybody else would get approval, if you had, theoretically a liscence to handle SCH I drugs? to do such an experiment. To what end would it be done..to see if one could produce psychosis/PTSD on command? only sort of aegis that shit would become airborne under, is govt black ops. Anywhere respectable, with real people, rather than government scum, would tell you to piss off, if they even bothered to reply to such a proposal, which they likely wouldn't.

Perhaps some would, those who are professional enough to give a shit enough to waste the oxygen discussing such a proposal, to shoot it down, for the good of others, Nichols, or Shulgin perhaps, but most, no, they wouldn't even bother.

Oral dose...What the fuck does it matter. Not much, I would say.

Here is the report: h**p://www.erowid.org/chemicals/lsd/lsd_history4.shtml

I was wrong about the figure, it was a little over 300mg. But nevertheless, this was  three TON elephant. Its true that many animals have vastly different metabolic rates and pathways than you humans do, but, put this way, the molar weight of LSD is 323.43g/mol, whereas that of mescaline is 211.257g/mol, so its around one third heavier, I'm doing a brutal buchery of an averaging here, so don't mind me,  I'm severely dyscalculic, and it would take me hours to fuck up the sums to a point where I couldn't be bothered fucking them up any more and asked somebody, so thats how its going to be.

So that makes a 500mg dose of mescaline (calc. as base, irrespective of salt counterion) contain what...some 675mg LSD? meh, fucked if I know, brain short circuits when it comes to math, but that will do. At any rate, considering less than half that felled an elephant weighing three tons via IM (not IV, obviously, from that link, since it was administered by dart rifle) and your average human weighs 100lb (rounded, probably more like 120, going from my own bodyweight and build, slim, wiry but not heavily built, nor yet build like a nematode worm)...3000/54.5kg=55.04...so something like the equivalent dose that poor elephant gotx55 for a 120lb human.

Just what exactly do you expect to happen from a 500mg dose (as mescaline delivery equivalent calc. as base)? I'd even wager on the cause of death, 70-30 spread bet between respiratory and cardiac arrest respectively, thats what my money is on. Refigure that monetary amount if it were to be tested on the CIA babyfucker that murdered the elephant, 100% on being slowly roasted to death with a propane torch by me, laughing bitterly all the while in angry lament for Tusko's loss.