Author Topic: Buprenorphine as trip terminator!?  (Read 90 times)

Oerlikon

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Buprenorphine as trip terminator!?
« on: December 02, 2011, 02:22:21 AM »
I have read 3-4 quite consistent reports on Erowid how buprenorphine can block psyhadelics
(LSD and Salvinior A in particular) if taken BEFORE psyhadelic.

Does anyone know if bupe can be used as "first aid" to terminate the bad trip!?
Did anyone tried it?!
I am so fascianted by this idea I am willing to does myself with some acid as soon
as I got it again,takesome bupe and write an report!

Sure,I handled every bad trip with no chemical help or small doses of alprazolam for anxiety
but some people become too frightened or dangerous under influence and since I am
often a "trip sister" for my friends that might be VERY usefulf to know.

Thanks!
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Sedit

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Re: Buprenorphine as trip terminator!?
« Reply #1 on: December 02, 2011, 04:35:13 AM »
While I can not truely say I can add a bit of personal experience that may or may not help.

When I smoke weed I get all the effects of a bad trip sans the hallucinations(most of the time). The fastest drugs that pull me out of this are opiates. Benzodiazepines without a doubt have there place here but they are not nearly as rapid acting or complete as opiates. I am pretty sure something is wrong with my head that causes THC to act in a similar fashion to indole psychadelics.

Given this I would be more then happy to try a small dose of buprenorphine after taking LSD. Problem is, there is no more LSD around my area and I honestly don't expect there to be any time soon unless I personally decided to make it and I wouldn't hold my breath on that one because Sedit don't make drugs he just does research. To many past scares has scared him straight and he has to much to lose in life now.

I doubt it terminates the trip so to speak but I would be willing to bet that the Endorphine release was enough to place one in a pleasent atmosphere without worrys as the trip went on. I also due to personal experience expect it to act sort of like a motion sickness aid so that instead of the hallucinations getting to out of control they take on a much more gental and pleasing form.
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fresh1

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Re: Buprenorphine as trip terminator!?
« Reply #2 on: December 02, 2011, 04:13:11 PM »
Quote
"
I doubt it terminates the trip so to speak but I would be willing to bet that the Endorphine release was enough to place one in a pleasent atmosphere without worrys as the trip went on. I also due to personal experience expect it to act sort of like a motion sickness aid so that instead of the hallucinations getting to out of control they take on a much more gental and pleasing form"

 I agree completely. Opiates are powerful enough to "moderate" a trip down to manageable levels, with their physical and mental euphoric effects. Buprenorphine, when taken be the "opiate naive" effecively has a potency equal to that of a strong opiate, e.g 1mg bupe roughly equates to 10mg of methadone,  which equates to about 30-40mgs of morphine, although it has a much longer "half life" due to its action.
 
   One other thing is due to its partial agonist/antagonist properties, its actually safer to use than most opiates, as it doesnt cause anywhere near the same level of respitory depression, that said, its not to be used without informed and careful consideration of all the facts which are involved, like all drugs taken, and preexisting medical conditions, such as asthma 8)

 Bezos, valium first, and xanax next, are the 'best' drugs to reduce the anxiety associated with tripping, and which can be the trigger which starts a 'bad trip' often with the thought that "I'm never going to come down...aaarrgh!"...opiates at this point will halve this, and possibly make it manageable, benzo's to a lesser degree, but its VERY dose related. SO bee careful, when giving drugs to compensate other drugs, always start low and titrate up CAREFULLY. If your tripping, and having to administer Valium or such, to someone, try and note the time, or write it down, hey make it a fun challenge ;D
 
 As for taking buprenorphine prophylatically (before) the trip, could make for a more relaxed trip, Taking 10-15mg of valium before a trip, can really smooth out some of the stronger rushes, which can be a bit scary for a novitiate,
  but IF a 'rescue' drug is needed, and you ALREADY have it in your system, taking more, may not work. Especially if its a fairly highdose of opiates, sure you could add some valium to the mix, if needed,

  BUT,, if things have got to the point rescue drugs are needed, you probably failed to heed a number of the time honored rituals and traditions associated with tripping ::) which, especially for the acid naive, or those going for a high dose, with expected +3 of higher effects. . . . .surroundings of all sorts, especially the surrounding people :) are VERY important, when avoiding negative situations whilst tripping.

Personally I wouldnt take bupe before a trip, although,i might take it after I've peaked and are 70% of the way down, then it would probably morph into this really mellow state that would last the next 18 hrs or so.

REMEMBER: If you dont take opiates on a regular (weekly, or more often) basis, then 4mg of bupe is a hefty dose to a 35yo 70kg male, who IS  familiar with dabbling in bupe once every few weeks, but could be called, effectively, "opiate naive" as he has only taken this dose 4-5 times in the past few months, and no other opiates whatsoever, however he has taken opiates in years gone by.

Peace love and happy trips

f1 ;)

Btw, imo, To take a high dose of a drug, which counteracts the drug you take next, is counterproductive :o, I'd love to know why you would want to?  Except maybe when ones binging on coke, and needs some vodka or beer with vodka, to moderate ones dry mouth :o
« Last Edit: December 02, 2011, 04:23:51 PM by fresh1 »
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no1uno

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Re: Buprenorphine as trip terminator!?
« Reply #3 on: December 03, 2011, 03:34:26 AM »
I've never known opiates to be all that effective with trip moderation. Amphetamine/Methamphetamine are the tools of choice when you want the trip over, right fucking now. Anti-anxiety medications may assist, they will not kill off the symptoms and if you've had a bad trip, or simply need to get your head together to deal with shit, it is usually fairly imperative to stop the trip cold.

I've used a variety of opiates to do the same job, in one intensely unpleasant episode that comes to mind - they (morphine IV & methadone IV) didn't work very well. It was a bad trip simply because of the shit that was happening around me, so real cause for anxiety, real need to end the trip as soon as possible (which sucked 'cos it was a GOOD trip). Methamphetamine IV worked extremely rapidly, to the extent that I've never tripped since without knowing where to find it.
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Tsathoggua

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Re: Buprenorphine as trip terminator!?
« Reply #4 on: December 05, 2011, 02:50:13 PM »
I can see the logic in bupe interfering with salvinorin A, as IIRC buprenorphine is a potent competitive antagonist at the KOR, however, norbuprenorphine is a partial agonist IIRC at the kappa opioid receptor. Given the very short duration of salvinorin-A however, and the damn long half life of buprenorphine, the salvinorin A would have worn off long anyway before any possible potentiation effect from norbuprenorphine would have chance to manifest itself.
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Oerlikon

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Re: Buprenorphine as trip terminator!?
« Reply #5 on: December 05, 2011, 05:17:19 PM »
Interesting no1uno,very interesting!

(Meth)amphetamine,especialy IV meth sounds like worst possible idea when someone is allready out of his mind or even aggressive!
How do you think that works?!
Last time I remember that one friend who took small ammount of bupe day before could not trip,even after taking 2x than rest of us.
It's probably good to mention that those trips were legit LSD but very weak.

I read more than few reports how bupe can block the trip and I can get the stuff easily,unlike pure meth.
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Sedit

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Re: Buprenorphine as trip terminator!?
« Reply #6 on: December 05, 2011, 07:34:43 PM »
Quote
(Meth)amphetamine,especialy IV meth sounds like worst possible idea when someone is allready out of his mind or even aggressive!
How do you think that works?!

It sounds like the amphetamine might have a stronger binding affinity then LSD for the Dopamine receptors but more research would have to be done as that's just a very rough guess.
There once were some bees and you took all there stuff!
You pissed off the wasp now enough is enough!!!

no1uno

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Re: Buprenorphine as trip terminator!?
« Reply #7 on: December 06, 2011, 11:10:05 AM »
Given the binding patterns for the act-alike drugs (the whole 2C/etc. series, including the N-modified ones) that would have to be a fair assumption. Dunno, I learned it through the old fashioned "try it and see" method. Works on every person I've seen in the position to have to use it for real. The reason you don't mix amphetamines with any other buzz

As for choosing the people you are around, yeah, for the acid newbees it is important... When trying to juggle shitfights and drama (think lots of clipseal baggies, scales, people asking for credit, people failing to pay for shit, etc) acid is the best tool there is IMHO. It goes directly against accepted thinking, but if you are trying to navigate a course through a very closely sown minefield, basing your movements on the body-language and actions of others (and your perceptions of same), acid is a bloody wonderdrug.

When drama gets hell violent, acid is a bad idea, if you need to get from there to a position where you can deal with violence and drama at any level, methedrine is the go. An uncaring, stoned as buggery, ambivalent state is, in that situation, as bad (if not worse) than tripping. Don't get me wrong, I love opiates (personal drug of choice is morphine sulphate), but they don't kill trips. As for dealing with violence, bad-mannered and/or aggressive assholes, I would have to say morphine/methadone/smack are the tools of choice for that cold blooded, unscattered, analytical approach (provided there is no acid involved).
« Last Edit: December 06, 2011, 11:19:01 AM by no1uno »
"...     "A little learning is a dang'rous thing;
    Drink deep, or taste not the Pierian spring:
    There shallow draughts intoxicate the brain,
    And drinking largely sobers us again.
..."

Oerlikon

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Re: Buprenorphine as trip terminator!?
« Reply #8 on: December 08, 2011, 04:30:16 AM »
Exactly,opiates are wonder drugs when you need clear thinking once shit hits the fan,just don't take too much.
Opiates are true wonder drugs and tools if you don't overdo them!
Personally I would chose tramadol or bupe over morphine any time but that's just me...

I take acid ONLY in F&L-like situations,when I have those few good but crazy and experienced friends to watch on me
(and vice versa) and some kind of mayhem to do! It NEVER gets boring! :D

I mentioned bupe since it has pretty unique receptor affinity,I bet there is somethin about trip-terminating effects there.
I witnessed and read about dozen such situations,too many to be coincidence!
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