Hi.

Today swim tried to make some isopropyl nitrite, and here it is:

Chemicals used:
Sodium nitrite [NaNO2]
Isopropyl alcohol [C3H7OH]
water[H2O]
concentrated (98%) sulfuric acid [H2SO4]
sodium hydrogen carbonate [NaHCO3]

Equipment:
A flask and a beaker


A flask was filled with 100ml of water [H2O] and 23.00g of dry sodium nitrite [NaNO2] and cooled in freezer.

A beaker was filled with 7ml of water [H2O] and to this, 8ml of concentrated sulfuric acid [H2SO4] were added slowly. When the mixture cooled, 23,5ml of isopropyl alcohol [C3H7OH] were added and cooled in freezer for 30 minutes, the same as the flask.

Solution from beaker was slowly added to flask with swirling by hand in the course of approximately  7 minutes.
When mixing the two solutions, bubbles of isopropyl nitrite and something else appeared. It looked like mineral water
with oil floating on top
When a solution was left to stand for a couple of minutes, it became more clear and organic matter floating on top became lighter in color (less yellow).

This was the test run for a scaled up reaction where additional cooling with salt/ice will be used and
maybe H2SO4 will be replaced for HCl.
Isopropyl nitrite is to be used in isonitrosopropiophenone synthesis.

So here is my question: Would the product be pure enough to be used in synthesis if it is to be separated from water, washed, neutralized with NaHCO3 and dried?

and here are some pictures of the end product:

Small scale with HCl will be tried first, then the results will be compared.

Tomorrow, the remaining of IPN will be salted out of solution and neutralized with NaHCO3 and dried over MgSO4 or something similar. MgSO4 has to be bought from the pharmacy

It will have to wait until tomorrow, because it is 2 AM now.

The headache was not severe, almost negligible during the reaction, but it became more apparent while transfering IPN out of the flask with an eyedropper to another container for storage. Some cardiovascular issues were noticed.
My heart started racing, I became a bit dizzy and my veins on my arms looked like I was on bodybuilding contest.

I had to remove to get some fresh air. After a couple of minutes I recovered back to normal, with no headache for now.

I hate working with nitroglycerin, it gives me a long lasting headache every time I work with it.

It is different for alkyl nitrites, symptoms stop much faster, if you are not exposed to high doses by intentionally inhaling it like some people do.

While working with alkyl nitrites, you can get exposed slowly, to reach higher doses and be unaware of it.
While under the influence, your judgment may get impaired and reactions may become slower leading to spills, exposure to higher doses..... spills can lead to fire, because alkyl nitrites are very flamable.

I think symptoms can be reduced with vitamin B12, vitamin C and others. I think antioxidants in general help, like from lemon and orange juice, I could be wrong...

As dangerous as lots of caffeine is, heisenberg is correct.  Things that also work are Meclizine HCl (look for anti-motion sickness, it's OTC), pseudoephedrine, and pseudo's replacement - phenylephrine (OTC nasal decongestant).

This is the exact procedure I use for making other alkyl nitrites, such as butyl and amyl nitrite, just calculate moles/grams of the alcohol and use directly.  It also works for methyl and ethyl, however special accomadations must be made due to their low boiling point (perhaps bubbling in another solvent, or performing the reaction in a freezer.  What are your plans with the IpONO? NaN3?

Can anyone elaborate in the short question threed on the production of azides from IPN please. Ill be greatful .

NG headaches are WAY overrated. A cup o coffee, a smoke, and some paracetamol does away with it. And constant exposure to NG makes you immune - hell there were cases of ADDICTION.

IPN is good for many purposes, I would use it as a sensitizer in thermobarics, but thats just me.

IPN is also a recreational drug :eek:

What about a decent mask. They come in all shapes/styles and colors. Hardly know youve got one on, and has filters that remove most things I believe. Good for headaches too.

That would certainly work, but I'd reserve them for the nastier gasses.