Ripped this from longcity.org, which actually seems to be a pretty interesting place.

Apparently a very powerful nootropic..

    "Superior to many known nootropes..." Antihypoxic, Antiamnesic, Low Toxicity, No Rebound/Withdrawal, sustained effects, enhances memory space and reproduction, no myorelalxant side effects, and improves cognitive process.
http://www.springerlink.com/content/7x75211p9734p626/
    Recommended for mnestic disorders from hypoxia or cerebral ischemia.
http://www.ncbi.nlm.nih.gov/pubmed/9606516
    Protective of mitochondria during trauma, surpassing many other nootropics.
http://www.ncbi.nlm.nih.gov/pubmed/9621180
    Positive modulator of AMPA receptors. Reduces damage from stroke.
http://www.ncbi.nlm.nih.gov/pubmed/12924225
    Helps with recover from stroke.
http://www.ncbi.nlm.nih.gov/pubmed/15079898
    Peps up mice who don't age well.
http://www.ncbi.nlm.nih.gov/pubmed/18078032
    Half life is between 0.37hr and 2.3hr in rats and rabbits. 500mg/kg maxed out blood levels.
http://www.ncbi.nlm.nih.gov/pubmed/21395015
    Restores dopamine levels in alcoholic rat pups.
http://www.ncbi.nlm.nih.gov/pubmed/8400184
    Improves escape and avoidance learning in rats.
http://www.ncbi.nlm.nih.gov/pubmed/8348043
    Normalizes D2 Dopaminergic at 50mg/kg, not 100mg/kg in rats in Diazepam withdrawal.
http://www.ncbi.nlm.nih.gov/pubmed/12802448
    Great for motion sickness.
http://www.springerlink.com/content/d63188562u612346/
    Patented in Russia this year (2011).
http://www.patentgenius.com/patent/8030493.html
    Chemical Book Link
http://www.chemicalbook.com/ProductChemicalPropertiesCB01328897_EN.htm
    Extremely bio-available in rabbits?
http://www.ncbi.nlm.nih.gov/pubmed/9783110


Seems like it could be made pretty easily.. the hiccup is how to synthesize 5-hydroxynicotinic acid, too bad OH isnt on the 6 position..

what do you much more knowledgeable guys think?

Toady has tried piracetam, aniracetam and pramiracetam, pramiracetam has so far, been by far the best of the racetam nootropics. Taken with choline, as they enhance choline uptake, and will cause depletion of choline otherwise.

Other nootropics Toady has had experience with: huperzine-A, galantamine, both anticholinesterases. The former is also an NMDA antagonist however, and the latter is an agonist at the alpha7 subtype of nicotinic acetylcholine receptor, which gives it additional nootropic activity. The R&D work is underway too, on acylpiperazine-based AMPAkines, sunifiram to be the first of the family to be synthed (1-benzoyl-4-propionylpiperazine). Damn potent stuff, by weight, this one is active at 0.001mg/kg IV, 0.1mg/kg per os.

Can't wait to try it out. Toady has a memory problem, severe impairment of working and short term memory, and difficulty encoding long term memories. And there is absolutely no help at all in the UK for memory impairments on the NHS, aside from alzheimer's or other dementia types. Toady can't afford private medical care on his income, he wishes he could get galantamine on rx, he tried it once, bought some online and had real good results, but its way too expensive, and he couldn't afford to continue with it

Anyone had experience they care to share using any of the AMPAkines? reports seem to bee few and far between, although the handful of bioassays of some of the CX-series seemed to bee quite positive, side effects minimal. And they were all done by people without an existing memory or cognitive impairment, effects should bee more noticeable in people who actually have a problem to bee treated.

Are choline supplements needed with AMPAkines? Toady would imagine they are, journal references studying their pharmacology where microdialysis probes were implanted in rats stated that they induced ACh release and cause release of BDNF (at least, the LY-series and CX-series AMPAkines induce BDNF release, so Toady imagines this should hold true for sunifiram/DM-235.

(quick question...propionyl chloride is watched as a drug precursor, isn't it? IIRC. its used in the production of fentanyl or its analogs? is benzoyl chloride watched? There are quite a few active derivatives of DM-235 and its cyclic analog DM-232, although DM-235 is the most potent thus far in the series)

Sunifiram should work out pretty cheap though. Piperazine is OTC as a de-worming treatment, in packs of several 4g packets, and at 0.1mg/kg (oral) 8g would work out as nigh on a lifetime supply, assuming preliminary bioassays turn out to give positive results.