Had no mescaline ready, so figured what the heck....

Just when I thought there was no hope for either one, i combined the two and was
seriously impressed with the results, it felt identical to 75ug of acid in every respect.
Took the 3mg of 4-aco-dmt first, then 1/2 hour later, the 300ug of 25i complexed to HPBCD under tongue, music was mind-blowing as was walking out in nature.

tryptamine + pea, this was the closest trip to LSD combining research chems i've ever had without taking actual LSD.

There was none of the sedation or muscle-paralysis of 4-aco-dmt (which I absolutely hate), it was an all super incompassing mind-manifesting combination, have not tripped in over 3 weeks, pupils were as big as saucers, confounded that it worked so well. I'm still shaking my head in disbelief.

duration of the trip was about 4 hours.
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During the last 2 hours of the trip, my sp drove me out to the mall, we went shopping for a
new bathing suit, normally I detest going to the mall, but this time, i was in 7th heaven, i was completely taken in with the smells of the cookies and bakery delights in the mall, the colors were amazing, walking into spencers, i heard led zeppelin's misty mountain hop, the music sounded so amazing....the colors and posters glowed with an inner light, i so loved all the tryptamine jewel-like encrested visuals immediately recognized as belonging to the tryptamine and ergoline family, i had complete mobility and the euphoria was constant and astounding. Victoria's secret was the most intensely lit up of all the places, colors super-bold and perfumed smells captivating, the giggles of teen-age girls darting about the place were magnified to incredible hearing levels, I laughed at the absurdity of it all, man what a great time. I could not have had more fun if I had taken 100ug of actual acid. all my senses were magnified to incredible levels, my mind making hundreds of new associations at the speed of light, i was astounded at the level of the trippiness, complete and utter fun. there was a storm outside as we left the mall, and I reveled in nature and the rain.
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It was the most fun i've ever had in a mall, ever. was so impressed with the trip, decided to combine the two into "one" for future use next month--->Took a 1" x 1" blotter #101 filter square cut from a filter disc, sprinkled 3mg of 4-aco-dmt onto the top, then dropped on 300ug of 25i-nbome onto the blotter, the 3mg of 4-aco-dmt dissolved into the blotter along with the 25i-nbome, forming a fully mind-manifesting blotter piece for future use, will give it a go again in a month. The trip last night was one of the low-dose best trips i've ever had in my life, fully visual and completely mind-manifesting and highly euphoric, i know that LSD has both a pea and a tryptamine backbone...this combination of 4-aco-dmt tryptamine and 25i-nbome pea had me completely fooled into thinking i took a 75ug to 100ug actual acid blotter it was that good, top notch, short lasting, and extremely cheap to boot.
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I guess I should explain myself....i've studied the receptor agonism for psilocin...and it is actually very very similar to the receptor agonism for LSD...except for the fact that the 5-ht2A agonism needs to be move up a notch in order to approximate the agonism that LSD has for the receptor...psilocin = 2.14 at 5-ht2A while lsd = 3.54 or so, while the receptor data for 5-ht7, 5-ht6, 5-ht5a, 5-ht1a, 5-ht1e of psilocin is very very similar to that of LSD's...only that psilocin is about 3/4 notch down in intensity as compared to LSD for these receptors.
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p.s. the problem i have with 4-aco-dmt is that it is extremely sedating, which is actually a good thing, as it indicates great power at activating all the various 5-ht1 receptors, the only problem is that the 5-ht2a agonism (which is stimulating) is very very low, all it needs is a "little help" in raising that 5-ht2a agonism...and that's where 25i-nbome comes in, 25i-nbome lacks 5-ht1 agonism (unfortunately, and it is what keeps it from being mind-manifesting)....but it is great at 5-ht2a agonism.....25i-nbome has always been "almost there" as far as being just like acid....only that it lacks 5-ht1a, 5-ht1e, 5-h-ht1d, 5-ht7, 5-ht6, 5-ht2b agonism properties...and that's where the 4-aco-dmt comes in....to contribute what it lacks.

You know how acid has that feeling like you are discovering something "new and exciting" at every turn?....and that fantastic mystical and mind-manifesting mind state? you get all of that when you combine the two....along with no sedation, but rather you are free to roam around and explore...just like with acid...thanks to the 5-ht2a agonism being raised slightly...no more laying on the couch unable to move taking 4-aco-dmt alone...you spring to life with vitality and your brain makes 100's of new connections, it is phenomenal...all for pennies.

p.s. If anyone else tries this, i recommend just dont go crazy on the 25i-nbome dosage, it only needs to contribute a slight effect to the 4-aco-dmt in order to raise it's agonism of 5-ht2a a slight bit, if you overshoot the 25i-nbome by too much, you will end up with a trip like DOI or DOM or 2ce or other synthetics give, which all overstimulate the 5-ht2a receptors over all else, you don't want that, you want the 5-ht2a agonism to come in "midway" or so on the receptor agonism chart, you don't want it overpower 5-ht1a, 5-ht7, 5-ht6 agonism....notice how LSD stimulates 6 other receptors (5-ht1a, 5-ht7, etc.) more powerfully than it does the allmighty 5-ht2a receptor. see Ray for data, i have a link to this in my other threads.
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Just to show that I'm not pulling anyone's leg on the receptor agonism data...take a look at
the agonism of psilocin as compared to LSD...notice the extreme similarity, the only difference is that LSD is "more potent" as compared to psilocin concerning the activation....and that LSD keeps the 5-ht2a agonism "up there" in strength, whereas 4-ho-dmt at 2.14 is just barely above threshold (anything below 2.00 is not really perceptable, whereas 4.00=maximum affinity)

LSD:
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5-ht7 = 3.77.....the novelty receptors, "new & exciting", stimulates new learning, CAMP reward system, dmt = 4.00! max)
5-ht6 = 3.75.....(the novelty receptors, "new & exciting" stimulates new learning, CAMP reward system)
5-ht5a = 3.64
5-ht1a = 3.73.....(5-ht1 make up 80% of the brain's 5-ht receptors!)
5-ht1d = 3.70.....(5-ht1 make up 80% of the brain's 5-ht receptors!)
5-ht1e = 2.62.....(see wikipedia to learn about these receptors...5-ht1e is involved in memory regulation and much more)
5-ht2a = 3.54

4-ho-dmt:
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5-ht7 = 2.82
5-ht6 = 2.82
5-ht5a = 2.83
5-ht1a = 2.88
5-ht1d = 3.40
5-ht1e = 3.03 (mescaline also activates 5-ht1e at this same strength)
5-ht2a = 2.14 (in order to turn psilocin into more of an LSD-style trip) we simply elevate this to "about 2.60 or so" via adding in 25i-nbome at a threshold dose of 300ug.

25i-nbome:
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5-ht2a = 4.00 Nichols found 25i-nbome to be 100 times more powerful than LSD at this receptor, believed to be the "key" to turning on psychedelic activity...p.s. if this is "blocked" in psilocin via knock-out gene mice...scientist found the hallucinogenic activity is also blocked.
5-ht2c = 3.98

5-ht2a agonism strength is important as it imparts visual activation, empathetic insights, psychological strength, euphoria, stimulation, decreases "confusion"/increases lucidity. Mescaline by stimulating the alpha-adrenergic and cardiovascular system receptors is able to effectively do what 5-ht2a agonism is able to do, without even activating the 5-ht2a receptor, give it up for nature! But 5-ht2a receptor activation is "nothing" but visual noise and euphoric fun and a half-ass trip if it is not linked to 5-ht1 receptors, forget about mind-manifestation if you have no 5-ht1/7/6/etc. activation. Just about all the synthetic psychedelic creations of man are heavy on the 5-ht2a activation but seriously lack activating the other important receptors "above" 5-ht2a agonism, hence there downfall...the exception being LSD, the semi-synthetic miracle.

hxxp://www.plosone.org/article/info:doi%2F10.1371%2Fjournal.pone.0009019

We are fortunate in that 4-aco-dmt is a "well-rounded" psychedelic on the RC market, a rare find indeed....well-rounded in that it activates a wide-range of receptors.

very interesting    Nice report tregar this journey you're having tweaking those receptors is most cool  thanx for sharing tis good to know

Important update: keep the 4-aco-dmt dose high and the 25i-nbome dose very very very low...here is why....

I've been using 10mg doses of 4-aco-dmt along with super sub-threshold doses of 25i-nbome (50 mcg, yes less than 100mcg)...for amazing trips...very similar to low doses of acid (100ug)....music sounds incredible, so good in fact that I spend hours of each trip just listening to new music, it is very mystical, euphoric, mind-manifesting, jeweled dmt-like visuals, incredibly colorful and emotional, i enjoy 450mg of mescaline all by itself once a month, but take these mini-4-aco-dmt combined with 25i trips at different time of the month to enjoy music for many hours, things become "new and exciting" just like with acid or dmt, A+ experience, top notch.

a warning to be careful to not allow the 25i-nbome to be very high or else vasoconstriction might could set in to some degree...I had better explain the importance of the 4-aco-dmt to remain a good dosage and why i believe the 25i dosage should be extremely light...

Mixing in only 50mcg of 25i-nbome with the 10mg of 4-aco-dmt allows the 4-aco-dmt to be the star of the show, the 5-ht2A agonism from the 25i-nbome is never allowed to "overpower" the more important 5-ht1a, 5-ht1e, 5-ht1d, 5-ht7, 5-ht6, receptor agonism provided by the 4-aco-dmt. this allows "serotonin firing" to still be shut down by the 4-aco-dmt, which in turn allows the 4-aco-dmt molecule to act as a replacement for serotonin, LSD and mescaline also shut down serotonin firing....this happens because they too only allow 5-ht2a agonism to remain very low on the scale of receptor agonism, allowing 5-ht7, 5-ht6, 5-ht1a, d, e, etc. to remain the star of the show, this is needed for a spiritual mystical experience...these 7, 6, and 1 receptors make up over 80% of the brain's receptors, and they shouldn't be overpowered by 5-ht2a agonism (from the 25i-nbome) or else you end up with trips given by synthetics like 2c-e, DOI, DOC, DOM, 2c-i, etc. etc.

these natural psychedelics including the semi-synthetic LSD are precise molecular keys which all hit the more important 5-ht1a, e, and 7, 6 receptors with greater force than 5-ht2a...whereas if you study the synthetics made by man they all allow 5-ht2a to overpower everthing else, which gives visual psychedelics with little to no spiritual meaning, and meaning-less visuals, ridiculous or empty types of mental states with no spiritual significance, no archaic or meaningful visuals, etc. What I am doing with the 25i-nbome is allowing the 5-ht2a to rise only so very slightly so that it does not overpower the other important receptors that 4-aco-dmt hits, similar to LSD which allows 5-ht2a agonism to be only "8th in line" behind other more important brain receptors which make up most of the brain. I've studied Ray's receptor project data for several months, it all makes sense when you compare the classic psychedelics to the synthetics.

The tiny amount of 25i-nbome that I used only "lit up" the 4-aco-dmt workspace similar to how LSD does the same with all the other receptors before it in strength. It is a remarkable experience very similar to acid in effects, so similar in that it is mystical, brightly lit work space, euphoric, very spiritual, completely able to move around and not be sedated by the 4-aco-dmt, very emotional and colorful, with meaningful visuals and thoughts, 100% mind-manifesting. If the 25i-nbome becomes too high however (above 100ug or so)...then the quality of the trip dramatically deteriorates as the 25i-nbome 5-ht2a agonism overpowers the importance of the 4-aco-dmt...becoming nothing more than a synthetic poor quality trip.

In other words, what I'm trying to say is that 10mg 4-aco-dmt plus 300ug of 25i-nbome sucked (since the 25i overpowered the 4-aco-dmt) while 10mg 4-aco-dmt plus 50mcg of 25i-nbome is phenomenal, very much like acid in it's effects, things seem new and exciting (especially music) and exploring...along with the super enhanced colors, euphoric emotions, dmt jeweled like visuals, humor appreciation, etc.

Mescaline and acid are still King, but I'll tell you, this 4-aco-dmt plus micro super sub-threshold amount of 25i-nbome is very incredible, and right on the heels of acid.

I don't much like 4-aco-dmt over 10mg, because when I've taken 13mg of it, it becomes "just like mushrooms" to me, especially when it is taken on an empty stomach, there is about a 30 minute period of nausea for me, and some anxiety, and the whole trip feels like there is an outside entity controlling my emotions, thoughts, the way I perceive things....it really bugs me out...i much prefer mescaline or acid over higher doses of 4-aco-dmt....

mescaline and acid at high doses are incredible (i much enjoy 450mg of mescaline which is like 165ug of acid to me, but even more visual)....but i don't much like 4-aco-dmt above 8 or 10mg, mushroom trips just like Hoffman had told terrence mckenna "feels like somebody is in there" controlling my thoughts and actions. in the future i'll always keep my 4-aco-dmt at 8 to 10mg and not any above that.

mescaline and acid are still my top favorites, always will be, they are very similar to me as well, mescaline is a little bit more visual at really high doses but a bit easier on the mind....but I prefer either one, as they are both super great.

Lets edit that bit out, but my point precisely. I do think some of these newer psyches have a useful push for more research to be done in the community though, and have gotten many people who otherwise wouldn't be interested in psychedelia very interested.
Having yet to try mescaline, the lysergic compound has become a favorite, it is definitely on the list for the future.