Author Topic: S,S Threo ethyl ester ritalinic acid  (Read 208 times)

jon

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S,S Threo ethyl ester ritalinic acid
« on: June 11, 2012, 09:41:48 PM »
i prearared this in my room while mom and dad were sleeping
i got some laevo tartaric acid.
and freebased the eph much like crack it was an oil that would stick to the glass and harden.
so now i wash any bicarbonates off and add in calc l tartaric acid i always use more.
the l isomer dissolves leaving the d isomer.
so i combine this with the rinses and trash from the froeebasing and i little when acid how little s,s, isomer precips from this were talking 1 % or less.
not even worth it.
but it is very convenient.
so now i dry this and use 5% acetic acid and air dry on plate with fan i scrape up.
being too lazy and circumstances to recystalize it.
i cut with mannitol and try this

it is very clean almost no tcachy cardia.
no scatteredness.
the focus is more clear basicall no side effects.
so next comrades is how to turn that mother liquor into r,s racemate in ethanol (dry) with catalytic acid.

overall very clean recommend this and isomer is so potent yet so few sode effeccts couple that with recovering the mother liquors and racemizing them you got som e pretty good atom economy going on here.
p.s.it does'nt even burn the nose i can't feel it going up i could cut with procaine and make lots of money.
very clean.
« Last Edit: June 11, 2012, 09:43:35 PM by jon »

atara

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Re: S,S Threo ethyl ester ritalinic acid
« Reply #1 on: June 11, 2012, 10:59:42 PM »
So my prediction was hazily accurate?

carl_nnabis

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Re: S,S Threo ethyl ester ritalinic acid
« Reply #2 on: June 12, 2012, 12:27:21 AM »
very nice one! ;D
I also prefer my drugs to be enantiopure and you made that ethylphenidat look pretty interesting for me since you wrote about it the last time i will definitely give it as pure eutomer a try now ;D
"It's like the drug trip I saw when I was on that drug trip!"

jon

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Re: S,S Threo ethyl ester ritalinic acid
« Reply #3 on: June 14, 2012, 02:51:20 AM »
it's basically like racemic witout many of the side effects especially tachycradia.
it's safer to do this enantio pure.
focus was much better too.
what i want is an easy way to isomize it back.
i was thing strong wcid + r,r, - s,s, ritaln at cold temperatures.
that sounds almost imosiiiblle to fuck up.
« Last Edit: June 14, 2012, 03:16:31 AM by jon »

carl_nnabis

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Re: S,S Threo ethyl ester ritalinic acid
« Reply #4 on: June 15, 2012, 02:06:56 AM »
its just pure stimulants have this sort of magic... i should tell a little story from a friend about this:
He spoke with his grandfather, a mediciner and imprisoned short time in a concentration camp. they spoke about the magic caused from the claviceps fungus through the ages blabla anyway,
both had the purest methamphetamine pure eutomeric isomer one can imagine, the grandfather said he never felt much from that panzerschokolade (tank-chocolate literally) or pervitin, the grandson replied "yeah, and then you walked forty miles with a 20kg backpack or what?"
he answered nothing but his look said it all ;D.... we think after he described me his face it was the first time the granddad realised how true this was ;D
you could say "what happened?" "nothing" "what changed?" "nothing too.. but it was great anyway ;D "
"It's like the drug trip I saw when I was on that drug trip!"

carl_nnabis

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Re: S,S Threo ethyl ester ritalinic acid
« Reply #5 on: June 15, 2012, 02:34:14 AM »
puuuh  it is an ester, acid and amine, its like you can change the direction of d-pseudoephedrin to l-ephedrine inequilibrium using a strong acid through inversion of the OH, but only to every 4 isomers using a strong base, because both chiral groups are involved but this one?
im definitely too stoned and beer and stuff good nite ;D
"It's like the drug trip I saw when I was on that drug trip!"

atara

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Re: S,S Threo ethyl ester ritalinic acid
« Reply #6 on: June 15, 2012, 11:31:59 PM »
A base might do it, but only something like lithium diisopropylamide. It might just eat it.

You can try to protect N, dehydrogenate/rehydrogenate the alpha,beta carbons (both chiral centers) over Pd/C with some hydrogen, which should racemize everything, and then deprotect N. Or if you use a benzyl protecting group, you can deprotect and racemize in one step, which might be optimal. I think that's the best bet for something like MPH.

So... (R, R) MPH + BnCl -- (Pd) --> BnMPH( - H2) -- (Pd/H2) --> (rac) MPH + tol

where the notation (- H2) indicates a loss of hydrogen.
« Last Edit: June 15, 2012, 11:34:46 PM by atara »

jon

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Re: S,S Threo ethyl ester ritalinic acid
« Reply #7 on: June 26, 2012, 01:28:48 AM »

this was the threo isomer
it was made from phenyl ethyl oxalate (which is why it burns so bad if you snort it)
a simple acetone wash gets rid of this.
i

carl_nnabis

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Re: S,S Threo ethyl ester ritalinic acid
« Reply #8 on: June 26, 2012, 02:54:45 AM »
just got logged out while replying  :o so good i expected this and saved seconds before!  ::)

do you mean the chinese material has usually enough impurities of this shit that it is actually noticeable?
ehhh... thats a bit like one buys grey or red colored mdma and its actually caused through iodosafrol or the nearly insoluble black mercury chloride(not mercorous, thats hgcl2 iirc) impurities... because:
i think its logical oxalic acid together with phenethylalcohol should be the first metabolites, and the former will build up in the kidneys to form calciumoxalate clumps, one of the many species of so called kidney stones. not sure if they have another english name, just literally translated.
But i have not even tried the racemic ethylphenidate yet.

to your problem youre right HCl will do but there are some alternatives after a quick look it seems like d-tartatic (may some left if you made the l- yourself?) dissolved in methanol will do the job aswell, like the enantiospecific methylphenidate synthesis in rhodiumĀ“s archive claims.
look at the last scheme on page 3, step 13-14 are carried out with HCl but essentially its the same like 11-12 so they mention you can use these reagents as well. i guess d-tartaric in MeOH looks attractive... potassium tert-butoxide as opposite is a whole different story ;D
hxxp://www.erowid.org/archive/rhodium/pdf/threo-methylphenidate.pdf
"It's like the drug trip I saw when I was on that drug trip!"

jon

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Re: S,S Threo ethyl ester ritalinic acid
« Reply #9 on: June 26, 2012, 04:11:16 PM »
well when you wash it with acetone it leaves this oily residue and it does'nt burn a bit afterwards.
there are nmr's on bluelight but you gotta be a member.
to download them
and to racemize it would no be a simple task it would probably require a strong base like lda to deprotonate the 2 position.
i was thinking i could just play with the stereo chemistry of the ester but all that would have yeilded is erythro L ethyl phenidate.
all i could find was l-tartaric acid so i used what i could find.

jon

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Re: S,S Threo ethyl ester ritalinic acid
« Reply #10 on: June 26, 2012, 07:25:41 PM »
lots of mechanical loss but the l-isomer has zero activity so it's not really loss if your'e not selling it.
i can see it being sold at a premium since it has almost zero side effects.

tregar

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Re: S,S Threo ethyl ester ritalinic acid
« Reply #11 on: June 27, 2012, 12:01:13 AM »
nice one! congrats on the invention.

jon

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Re: S,S Threo ethyl ester ritalinic acid
« Reply #12 on: June 27, 2012, 08:39:06 PM »
well my conudrum is that what to do with the l-threo isomer i can't just jumble the ester i would get erythro l-eph.
so my thoughts turned to using a strong base but with the amounts i have it's not even worth the bother.
i think i would have to strip it back down with aq KOH to jumble it up, and isolate the acid and recrysystalyze essentially start all over again.
« Last Edit: June 29, 2012, 06:06:11 PM by jon »

jon

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Re: S,S Threo ethyl ester ritalinic acid
« Reply #13 on: July 06, 2012, 03:34:12 AM »
got it down to and art now.
very little mechanical loss
the main side effects it eliminates are paranoia, abdominal pain, and that scatterbrain effect you get with dari's the focus is much clearer and it feels very cleean but becuase it is so strong you have to take that into account and not misjugde because on paper the say twice as potent.
but it's a little stronger than that even.
because the inactive isomer is'nt competing for the dopamine receptor so you have pure isomer making a b-line to the pleasure center of the brain like a silver bullet good good stuff.
and the only way to keep it going is to take l-dopa which is what i do.
when you take l-dopa take 600 mg's 2 hours before you eat any protein (amino acid)
and take vit c and b-6 because they are co-factors in the manufacture of shit tons of dopeamine in the brain in just a couple of hours damn that trick is slick.

carl_nnabis

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Re: S,S Threo ethyl ester ritalinic acid
« Reply #14 on: July 08, 2012, 07:53:52 AM »
very impressive! too bad l-dopa is only avaible by prescription here :(
so you made the potassium salt of ritalinic acid while de-esterifying, and esterified it again with ethanol?
when you say "very little mechanical loss" i can just barely imagine some tweaked guy sitting there washing his filters and beakers etc over and over again using like only one milliliter each time to get even the last single milligram out ;D
« Last Edit: July 08, 2012, 08:00:20 AM by carl_nnabis »
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jon

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Re: S,S Threo ethyl ester ritalinic acid
« Reply #15 on: July 08, 2012, 10:44:26 PM »
oh no i have'nt got enough l-isomer to even bother.
it's a 3 day reflux carboxylic alpha protons enolize very slowly.\
i found a chineesse place offering it for 3900/kilo
the have reasonable payment terms i have'nt heard from the chinks yet anyway.
i have to get back to work.