Ulipristal Acetate (UPA) is an orally active SPRM with antagonistic and partial agonistic effects on the progesterone receptor.35 UPA, a derivative of 19-norprogesterone, exerts its effects by binding to progesterone. It also binds to glucocorticoid and androgen receptors. The binding capacity to these receptors is lower than that of its antiprogestin activity. UPA shows in vivo antiglucocorticoid and antiandrogen activity at doses 50 times higher than needed for its antiprogestin effect.The antagonistic activity of UPA is similar to mifepristone but less antiglucocorticoid activity is expressed, thus reducing the risk of glucocorticoid effects. http://www.ebiochem.com/product/ulipristal-acetate-16041
Research from long Island university,based on clinical trials, UPA seems to be a reasonably tolerable and effective method of EC when used within 120 hours of intercourse. UPA is at least as effective as LNG when used within the first 72 hours after unprotected intercourse. However, UPA may be more effective than LNG when used between 72 to 120 hours after unprotected intercourse, extending the window of opportunity for EC. UPA may provide a new option for women who require EC up to 5 days after unprotected intercourse.
Research from long Island university,based on clinical trials, UPA seems to be a reasonably tolerable and effective method of EC when used within 120 hours of intercourse. UPA is at least as effective as LNG when used within the first 72 hours after unprotected intercourse. However, UPA may be more effective than LNG when used between 72 to 120 hours after unprotected intercourse, extending the window of opportunity for EC. UPA may provide a new option for women who require EC up to 5 days after unprotected intercourse.