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Author Topic: My OTC extraction for dried poppy pod to morphine freebase  (Read 189 times)

raiden

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My OTC extraction for dried poppy pod to morphine freebase
« on: October 02, 2012, 10:42:08 PM »
This is my idea for a easier acid base method... needs some experiment but theoretically I reckon I cud have a working tek within a few experiments...

IPA (or methanol) extract dried (deseeded) pods
Filter
Up Ph of IPA to 12 (precipes fats and other alkaloids)
Allow to settle then Filter
Lower the IPA to PH 9.1 (may require some evaporation to concentrate it)

If precipitates = You have M base to collect
If not evaporate and you will have crude M base


Sodium hydroxide (NaOH) is fine for upping PH and acetic acid for lowering.  I have a digital PH meter for this experiment.


Now I'm assuming is possible to alter PH directly in the IPA solvent  (please excuse my noobyness I am a beginner)


I have used the search and read some of the teks here but I didn't find anything satisfactory yet...   The main aim of this is for quick and easy OTC M base from dried pods.


Any suggestions / input appreciated kindly  :)  Please don't be too mean on me I am just a beginner!   :D

Balkan Bonehead

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Re: My OTC extraction for dried poppy pod to morphine freebase
« Reply #1 on: October 03, 2012, 12:01:49 AM »
Why would upping pH cause fats and alkaloids to precipitate? They are surely soluble in alcohol.

raiden

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Re: My OTC extraction for dried poppy pod to morphine freebase
« Reply #2 on: October 03, 2012, 01:15:06 AM »
I initially tried this in water and upping the ph to 12 succesfully precipitated all of the alkaloids (except the morphine) and some fats.

If this would work in IPA then it would be ideal but I have not yet tried.

If not a simple modification would be to do the entire process in water instead of alcohol but alcohol has 2 advantages
1. Its faster / easier to evaporate if need be
2. It extracts the alkaloids but not as much of the fats from the pods

I have already proved this experimentally by making both water and IPA extracts of dried pods.
The water extract weighed loads more proving that it had extracted far more unwanted plant matter - it was only active orally as you can't smoke enough of it because its not concentrate enough.

The IPA extract however weighed far less and was fairly potent - almost on par with raw opium and was concentrate enough for vapourising.   :D

raiden

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Re: My OTC extraction for dried poppy pod to morphine freebase
« Reply #3 on: October 03, 2012, 10:40:21 PM »
I spose I should probably stick to the classic patented method though really for guaranteed success and since its pretty easy  :P

Quote
Morphine is extracted from opium by stirring and/or heating, or preferably refluxing, opium in a basic solution of an alcohol, preferably methanol at about pH 9.   The pH may be adjusted by the addition of an inorganic base (alkali hydroxide, or carbonate), ammonia, and the like. Preferred inorganic bases include, but are not limited to, sodium hydroxide and potassium hydroxide.

After the extraction is complete, the alcohol extract is filtered to remove the undissolved particulate matter. The alcohol itself is then removed from the extracted alkaloids, preferably by evaporation under reduced pressure. The resulting residue, which contains the alkaloids, is mixed or extracted with an basic aqueous solution having a pH of at least 11, preferably an aqueous solution of an alkali hydroxide. This converts the morphine free base present into its anionic (morphinate) form which is soluble in basic solutions of pH values of 11 or above. Other opium alkaloids are relatively insoluble and, in general, at least partially precipitate out of the basic aqueous solution.

After removing any precipitate, preferably by filtration, the remaining alkaloids are separated from the morphine containing basic aqueous solution by extraction with a substantially water-immiscible solvent, such as toluene or benzene. Finally, the morphine free base is precipitated out of the resulting aqueous solution by adjusting the pH of the aqueous filtrate to pH 8.5 to 9.5. Preferably, the pH to precipitate the morphine ranges from about 9 to 9.3, and most preferably is about 9.1. This is accomplished by adding either an organic acid or a mineral acid. The yield and purity of morphine produced by this procedure are economically satisfactory.

Unless anyoe has any simplifications or links toother methods they would like to share?   ;D

carl_nnabis

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Re: My OTC extraction for dried poppy pod to morphine freebase
« Reply #4 on: October 04, 2012, 02:24:15 AM »
yeah indeed got two tips for you, but im too busy with being lazy to search them for you, ill just provide you with the terms you have to UTFSE with: theyre "ion exchange resin" and "polish kompot", jons has to be the starter of at least one if not even both, they are considered from some other members and of course me too as very helpful!
Also, the topics started this summer regarding opiate extraction, arent very helpful at all, i think its nearly a half dozen repeating the same question in some variation because everyone was just to stoned on poppy tea, and asked unconciously for spoon feed ;D

edit: actually, still to lazy to utfse for you and just erased some grammar and writing errors, i am thinking its the same topic you will find wih these search terms ;D
« Last Edit: October 04, 2012, 04:28:41 AM by carl_nnabis »
"It's like the drug trip I saw when I was on that drug trip!"

raiden

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Re: My OTC extraction for dried poppy pod to morphine freebase
« Reply #5 on: October 05, 2012, 02:07:18 AM »
With all due respect sir I did use the search engine but found some really poor a/b ideas and that was all.

However thank you for the kompot search term tip, which yielded this useful information...


An efficient method for obtaining morphine from domestically

grown poppies has been developed. Morphine was completely

extracted from dried poppy capsules with water-saturated

isobutanol containing 0.23% ammonia. By passage of the

extract through a cation exchange resin bed, practically all

of the alkaloid was adsorbed. Quantitative elution of

morphine from the bed was achieved with dilute aqueous

alkali. Crude morphine obtained by precipitation from the

neutralized and concentrated eluate could be converted to

pharmaceutical grade hydrochloride without difficulty. The

overall recovery of morphine was 90%.

One of the best OTC sources of ion-exchange resin is

companies that deal with water treatment.



http://127.0.0.1/talk/index.php/topic,526.msg5818/topicseen.html#msg5818


I'll leave this here for other noobs who will likely be finding similar threads and may find this one, that way not only do they have the patented a/b but also a link to the superior ion exchange resin method  :)


I realise it must be a bore to those of you who are experienced and regulars on this forum!  but i feel this thread is OK now :)  Thanks for the help.  I'm off to read a lot more on ion exchange  ;)
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