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Author Topic: Anyone with SciFinder or Beilstein access willing to do a query for me?  (Read 54 times)

Sydenhams chorea

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Anyone with SciFinder or Beilstein access willing to do a query for me?
« on: November 11, 2012, 07:33:57 PM »
I don't know if requests like this have been done in the past, but here goes: I currently have no access anymore to neither of both, and I was wondering if a kind member who can access a database could do a query on the synthesis of 1-cyclohexylpiperazine and post the results? I am specifically interested in the reductive amination of cyclohexanone with piperazine, and hope to find data in the results on the separation of both products 1-cyclohexylpiperazine and 1,4-dicyclohexylpiperazine...

Thanks in advance.
It is perhaps the narcotic. Hyoscine affects certain people very oddly. One cannot be sure. Sometimes, these cases take strange forms. The victim becomes in a sense, 'mediumistic', a vehicle for all the intangible forces in operation around her.

java

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Re: Anyone with SciFinder or Beilstein access willing to do a query for me?
« Reply #1 on: November 12, 2012, 12:41:56 AM »
Requested by Sydenhams chorea


Arylamides hybrids of two high-affinity ?2 receptor ligands as tools for the development of PET radiotracers
Carmen Abate, Savina Ferorelli
European Journal of Medicinal Chemistry
2011, Volume 46, Issue 9, Pages 4733-4741
http://dx.doi.org/10.1016/0040-4039(94)85306-1




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Abstract
1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine 1 (PB28) and 2-
Methoxy-5-methyl-N-[4-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)butyl]benzamide 2 (RHM-1)
represent leads for tumor diagnosis, given their high affinity at s2 receptors. With the purpose of obtaining good candidates for s2 PET tracers development, hybrid structures between 1 and 2 were designed.
Excellent s1/s2 selectivities were reached when 6,7-dimethoxytetrahydroisoquinolinewas linked to an omethoxysubstituted arylamide (11a, 12a, 15a), and for these benzamides an intramolecular H-bond in the active conformation at the s sites, was hypothesized. However these excellent s2 ligands were accompanied by interaction with P-gp, which may limit their use as s2 receptor PET agents when tumors overexpress P-gp. Compound 15a whose P-gp interaction was just moderate represents an interesting tool for the development of s2 PET tracers useful in tumors overexpressing P-gp.
« Last Edit: November 12, 2012, 12:51:02 AM by java »
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lugh

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Re: Anyone with SciFinder or Beilstein access willing to do a query for me?
« Reply #2 on: November 12, 2012, 02:04:13 AM »
The attached article:

Reductive Amination of Aldehydes and Ketones with Sodium Triacetoxyborohydride. Studies on Direct and Indirect Reductive Amination Procedures

Ahmed F. Abdel-Magid ,* Kenneth G. Carson , Bruce D. Harris , Cynthia A. Maryanoff , and Rekha D. Shah
The R. W. Johnson Pharmaceutical Research Institute, Department of Chemical Development, Spring House, Pennsylvania 19477
J. Org. Chem., 1996, 61 (11), pp 3849–3862
DOI: 10.1021/jo960057x

appears to pertain to the methodology involved  8)
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Sydenhams chorea

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Re: Anyone with SciFinder or Beilstein access willing to do a query for me?
« Reply #3 on: November 19, 2012, 01:46:27 PM »
thank you very much java and lugh, I'm very grateful!
It is perhaps the narcotic. Hyoscine affects certain people very oddly. One cannot be sure. Sometimes, these cases take strange forms. The victim becomes in a sense, 'mediumistic', a vehicle for all the intangible forces in operation around her.
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