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Author Topic: Valerian root causing false positives for benzodiazepine.  (Read 50 times)

Sedit

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Valerian root causing false positives for benzodiazepine.
« on: December 13, 2012, 11:09:10 PM »
There have been multiple reports I have seen around the internet of this causing false positives for Benzos yet I can not find a single structure that should mimic the metabolism of benzodiazepines. 

Does anyone have any idea what metabolite is looked for in such a case.

According to the attached document Hydroxyvalerenic acid was the one shown to have sedative action along with a few other possibles. I can see how it would have affinity for the BZP receptor but I can not see how it should trigger on a drug test.

I would love to be able to purify and crystallize this substance but it only appears in very low concentrations in the root so I don't feel its practical.

The chemicals structures are at the end of provided document.
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Hawkwind

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Re: Valerian root causing false positives for benzodiazepine.
« Reply #1 on: December 14, 2012, 12:50:35 AM »
hxxp://www.mayomedicallaboratories.com/interpretive-guide/index.html?alpha=B&unit_code=80370
Interpretation

Benzodiazepines are extensively metabolized, and the parent compounds are not detected in urine. This test screens for (and confirms) the presence of: 

-Nordiazepam, oxazepam (metabolites of chlordiazepoxide)

-Nordiazepam, oxazepam and temazepam (metabolites of diazepam)

-Lorazepam

-Hydroxyethylfluorazepam (metabolite of flurazepam)

-Alpha hydroxyalprazolam  (metabolite of alprazolam)

-Alpha hydroxytriazolam (metabolite of triazolam)

-7-aminoclonazepam (metabolite of clonazepam)

-7-aminoflunitrazepam (metabolite of flunitrazepam)

hxxp://www.redwoodtoxicology.com/resources/drug_info/benzodiazepines.html
Metabolism
The benzodiazepines are well absorbed after oral administration and are rapidly distributed throughout the body. They are extensively metabolized by the liver, and in general, slowly excreted in the urine as pharmacologically inactive conjugated metabolites. Some metabolites may possess some pharmacological activity of their own, thus displaying the "next day" effects of some benzodiazepines. Oxazepam is a common urinary metabolite of several benzodiazepines such as diazepam and temazepam. Duration of detectability in urine is varied. Ingestion of therapeutic dosages may be detectable for 1-3 days while extended usage over a period of months or years can extend excretion times up to 4-6 weeks after cessation of use (depends on dosage & benzodiazepine).

Gypsy

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Re: Valerian root causing false positives for benzodiazepine.
« Reply #2 on: December 14, 2012, 09:05:16 AM »
« Last Edit: December 14, 2012, 09:08:03 AM by Gypsy »
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