Author Topic: Isomerisation of cannabinoids  (Read 97 times)

The Lone Stranger

  • Subordinate Wasp
  • ***
  • Posts: 198
Isomerisation of cannabinoids
« on: December 18, 2012, 09:10:56 PM »
I`ve looked around and read loads about it but most of it is unclear as far as times and PH are concerned .

Has anyone any experience with it ?

I`m not realy interested in chemistry explanations i want practical ones , practical over the counter ideas please .

For instance for a person that doesnt know how much oil they have in their alcohol , doesnt know how much of what cannabinoids are in the oil and hasnt got acsess to lab equipment . I did a lot of thinking about it years ago but the problem was that all the tips i could find depended on the amount of oil and the content of that oil . I`m not looking for perfection just for things anyone can do without to much hassle .

What i`m thinking is is does the acid get used = neutralised = one could maybe make the PH a certain level,and then as the reaction takes place measure it and if needs be add more or just judge when the possible reactions have stopped because the PH stays constant .

Before we start shouting ..... yes ..... i have some practical ideas and have tried it and the orginal oil came out stronger ....... but not strong enough ........ but one doesnt want to give to much away before one has got some advice ...........................................  any advice except " fuck off you idiot " ......

This one earns at least 1 honey point .....

lugh

  • Global Moderator
  • Foundress Queen
  • *****
  • Posts: 876
Re: Isomerisation of cannabinoids
« Reply #1 on: December 18, 2012, 09:45:41 PM »
Pleas read:

https://the-collective.ws/forum/index.php?topic=6027.0;all

and study:

https://the-collective.ws/forum/index.php?topic=6027.msg155411#msg155411

until you understand what chi posted  ;)  The end results from the effort applied  8)
Chemistry is our Covalent Bond

The Lone Stranger

  • Subordinate Wasp
  • ***
  • Posts: 198
Re: Isomerisation of cannabinoids
« Reply #2 on: December 18, 2012, 10:16:18 PM »
Thanks lugh ....... but that means that i would have to join that web site and i dont want to ........ the eliteist " welcome " i got on other chemistry sites was enough of an aversion therapy to last me a life time .

I`ve read " Cannabis alchemy " and a few other things on the subject but they are not OTC and street enough for what i want = power to the people without a lab or lab equipment .

Got any tips ? Anyone ?

antibody2

  • Subordinate Wasp
  • ***
  • Posts: 158
Re: Isomerisation of cannabinoids
« Reply #3 on: December 18, 2012, 10:59:47 PM »
Its been over 20 years since Ab2 isomerized weed oil so recollection/details are vague. Ab2 no longer even has the book.

But to answer one of your questions the H2SO4 is a catalyst, it is not consumed by the reaction, so if you add less it will take longer, if you add more it will go faster, but if you add too much you will destroy everything. But as far as monitoring the rxn, that is going to be tough. Both THC isomers will probably elute the same or very similar on TLC. What Ab2 would probably do is let the rxn go MUCH longer (24 hrs) to be sure everything is reacted.

The PH should not change over the course of the rxn, but if you are unsure how much H2SO4 to use, then checking ph might prevent you from adding too much

If you don't know how much oil is in your alcohol, evaporate it, then you will know. Besides, if you try an isomerize directly in an alcohol the H2SO4 may react with the alcohol. Not sure exactly how low a temp is required for H2SO4 to dehydrate an alcohol, but it happens at 100°C for sure and likely below as well.

As far as other methods of boosting potency go there is acetylation, which as you mention requires tough to source reagents. BUT there is a possibility that a much newer, safer and OTC acetylation reagent might work. Acetyl salicyclic acid. Ab2 has never tried it on THC, but it has been shown to work on tryptamines as well as aniline, so it might be worth a go. This rxn could be monitored on TLC  as the acetylated THC would likely have a much higher rf than straight up THC.

Ab2 has always wondered what acetylated THC would be like, be sure to report back if you decide to give it a go ... let Ab2 know if you are interested in trying and she'll get you some details or a procedure. It is a very fast reaction if it works...
« Last Edit: December 18, 2012, 11:10:11 PM by antibody2 »

The Lone Stranger

  • Subordinate Wasp
  • ***
  • Posts: 198
Re: Isomerisation of cannabinoids
« Reply #4 on: January 09, 2013, 08:28:34 PM »
Cool AB2 . Thanks .

EDIT - Did i read that right ?  ....... Acetyl salicyclic acid = aspirin !!!! = easy to extract from willow tree bark !!!!!


@ALL ---- >

A long ( and hopefully contraversial ) explanation of what i`m thinking ( details and spellin might not be good so please use yer brains )  ---- >

I used to be a real hashashin = one spent time thinking about the best ways to do cannabis . Cheepo over the counter idiot / TLS proof methods .......

So of cource one didnt smoke joints or bongs ...... one smoked a self designed glass pipe . The best pipe / method available .

The pipe got dirty quickly and the oils in it were a mixture of THC and other cannabinoids . The only real way to keep it clean was to let it stand in as pure alcohol as one could get ........ and then use boiling water and a metal coat hanger scratcher thingy to get the rest shit thats stuck in the bend between the bowl and the stem out .

The stronger the alcohol the better it disolves the shit . The strongest ethyl alcohol is EXPENSIVE and hard to get . BUT .........  whats called spirits  = alcohol with nasty tasting shit in it so that alkis dont drink it ....... is freely available and only costs a few euro$chekel$ .......... It is / was ....... said to be methyl alcohol ........ ( Dont start shooting untill youve read the rest !!!! ) ........ BUT ...... this freak had a look at wiki and it says there that what is here called spirits is in fact the strongest ethyl alcohol mixed with very small amounts of things like pyridine , MEK = Methyl Ethyl Ketone and a bit of benzin to make it unpalatable . The law in the EU says that its not allowed to put poisonous things in it only things that taste shit and might make a person puke a bit .


Then one remembered that one had read about isomerisation and acetylation in " Cannabis Alchemy " and a few german books . They talked about cooking cannabinoids in alcohol ...... with no water ....... and one drop of sulphuric acid per gramm of oil for a few hours .

They also talk about useing pyridine in a recepie and that that could make it more effective .

Strangeness thought in one liter of spirits in a glass flask he had between 5 and 10 G. of mixed cannabinoids / oil . So first he filtered it through a coffee filter and then threw a few teaspoons full of active charcoal for cleaning swimming pool pumps into it and filtered it again . Then he threw 5 drops of sulphuric acid in it and cooked it for 2 hours . Then he put it in a stainless steel bowl and put that in a water bath and heated it till most of the alc evaporated . After a while the shit got thicker and it was easy to see that the alc had nearly boiled off and that there was a sort of oily film on top of the rest liquid . Then i threw loads of water into it so that the oil separated from the greasy water / alcohol bit on top ...... wich i thought must be either soluble in water because its soluble in alcohol? or that the bits that arent soluble in water = benzine would eveporate off under the temperature that alc boils at ....... and then poured it off and let the leftover oil dry for a few days .

Results = a hard to handle and smoke oily / tary ....... oil ...... wich was very difficult to get off the sides of the stainless steel pan ............ wich was at least subjectively better than just smokeing the shit straight out of the pipe . It also tasted a lot less shity and didnt make me cough as much to .

2nd try ----- > Did the same again but that time i thought fuck it just make the alc / oil mixture PH 4 and then cook it and see if it makes a difference . So it got left to stand overnight and then cooked for 1 hour . Then i cooked the alcohol off and did the same water wash . Then i added some active charcoal powder to it and heated it a little in the water bath again so that the charcoal mixed with the oil and soaked it up . After it cooled i poured the left over unused charcoal off .

Results = That time it did more . The problems with handling oily shit and smokeing it were solved by the charcoal mix . The charcoal dried the oil out and made it dead easy to scratch off the stainless steal bowl . It was also MUCH easyer to smoke ........ BUT ..... i think ..... as the charcoal is not fully burned carbon it gets hot to quick and kills a lot of the effect of the oil .

To solve that i was thinking maybe it would be better to add pure ash .

Anyone any ideas , hints ....... helpfull sugestions other than hang yourself idiot ....... I`m not realy expecting to get any acurate method because 1 - we wont know how much oil is in there ........ it could be weighed after evaporating the alc off it before doing the cooking / acid bit but i think that any neighbours would smell if someone was evaporating loads of alc . ( < ----- Had trouble with neighbours smelling acetone and benzine vapours ) . 2 - We dont know how much of what is in that oil ......... BUT maybe there is a way to do a sort of as good as possible cleaning and conversion ? Its just to convenient and cheep and OTC / DIY doable an idea to not have a look at .......... the oil is there for free  , the alcohol is there very cheep and there is pyridine there ....... and sulphuric acid is cheep and easy to get ........ and non of the things needed are suspicious ......... and the described methods of isomerisation in a lab arent exactly hightech chemistry ...... more lowtech = hit a molecule with a big acidic and hot hammer for a few hours  .........

The stainless steel bowl was probably not a good idea because of the sulphuric acid ? IF it gets tried again it would be with weighing as AB2 sugested , better filter paper , charcoal granulate instead of charcoal dust so the filter paper doesnt get blocked and the finest charcoal dust doesnt go through the filter and a glass flask instead of the stainless steel bowl ...... and pure ash to soak up the oil and make it smokeable .

Also maybe try to defat / clean the alcohol mixture before the acid is added by putting something like butter or wax or gelatine into it = the butter floats on the top and when cooled in a fridge it sets hard and other fats and waxes with it that can then be removed  .......  just like cleaning wine .


If you have survived reading this so far please give me credit for trying to use as untechnical and as anoying descriptions for chemists that take themselves to seriously as possible ........... like cook instead of reflux ........ and the word recepie ...........



« Last Edit: January 10, 2013, 03:54:47 AM by The Lone Stranger »

LilDookie

  • Larvae
  • *
  • Posts: 16
Re: Isomerisation of cannabinoids
« Reply #5 on: January 11, 2013, 10:59:24 PM »
I have a file you may be interested in, but it's 127mb and I cant get it to upload.

This is what I have
countyourculture dot com/2011/08/28/dr-atomics-marijuana-multiplier/
The cost of sanity in this society is a certain level of alienation.
-Terrence McKenna

The Lone Stranger

  • Subordinate Wasp
  • ***
  • Posts: 198
Re: Isomerisation of cannabinoids
« Reply #6 on: January 12, 2013, 01:51:16 AM »
@ LilDookie . Thanks . You made my day . I bought that comic when it came out and i hadnt got a PDF copy of it .

I`m interested in the 127 mb file .

@ Ab2 . " Ab2 has always wondered what acetylated THC would be like, be sure to report back if you decide to give it a go ... let Ab2 know if you are interested in trying and she'll get you some details or a procedure. It is a very fast reaction if it works... "

Thanks . I`m interested . Please beam me some info over .


@ The thread ---- >

I just dug the last bit of the last try i made out and tested it ...... and its subjectively stronger , much better and easyer to smoke than the oil it was made from and at least most of what had been smoked through the pipe = something worked .

The three pictures are of refluxing the oil in spirits in a kilner jar in a water bath ...... the solvent being boiled off with a bit of greasy shit floating on top before washing it with water ..... and the end result before mixing with charcoal . The blackness in the oil comes from the charcoal powder because the coffee filter wasnt good enough . The oil itself was a dark red colour .

Once it was mixed with charcoal there was much more .

I understand that for you real chemists what i`m talking about is gutter chemistry and the idea of recycling the shit out of a pipe is for you a bit like coke bottles in a car or makeing LSD from fosters beer or getting high smokeing banana skins ...... BUT ...... its there and if it can be done cheeply and safely its a good thing ......... and ..... if chemists are to proud to do it someone else will have to do it . 5 - 10 G. of good oil for next to nothing , with little risk and OTC chemicals is a gift from god that cant be ignored for a lot of people .



@ Vesp - My poison puke green watched tag thingy is gone !!!! Please can i have it back again ? My fans could think that i`ve dropped my principals sold out done a deal and have become an arse licker !


« Last Edit: January 12, 2013, 02:47:59 AM by The Lone Stranger »