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Author Topic: Piracetam  (Read 672 times)

Methyl Man

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Re: Piracetam
« Reply #20 on: April 20, 2011, 08:58:01 PM »
Anyone have thoughts on the interactions (if any) between nootropics and cannabis?

I've often wondered if the net effect of Piracetam or similar would be that I would still get the same euphoria/ineffable feeling from the THCs, but the short-term memory thing would be remedied.

I'm sure that's probably too much to hope for...

Thing is, I don't *think* I have any age-related short term memory deficit, but I really wouldn't know because of the THC-related short-term memory reduction that masks it (if it's there).
« Last Edit: April 20, 2011, 08:59:41 PM by Methyl Man »
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aniracetam

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Re: Piracetam
« Reply #21 on: April 20, 2011, 09:41:27 PM »
yea, it definitely clears the fog, so to speak. piracetam is especially effective when taken with alpha-gpc.
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qrj

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Re: Piracetam
« Reply #22 on: January 29, 2012, 07:22:05 PM »
piracetam works good for me, though i strangely haven't managed to damage my brain enough to be noticeable
 ~2.8 grams per day.
even trough my last opiate withdraw it seemed that it gave me some physical boost, too.
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tryl

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Re: Piracetam
« Reply #23 on: January 29, 2012, 07:38:06 PM »
is good to stock up on, given the opportunity, increases the effect of all PEAs, does work, have been using it on and off for years, on doses in the neighborhood in 4 do 6 grams a day.

qrj has the metabolism of a crack addicted colibri, so do don't take her word for it.

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Tsathoggua

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Re: Piracetam
« Reply #24 on: January 31, 2012, 11:39:30 PM »
Don't know about aniracetam being the best of the bunch. Out of the three I have tried, piracetam, aniracetam and pramiracetam, pramiracetam has definitely been the most effective.

Of note, aniracetam is fat soluable, as evidenced by its lack of taste, and extremely poor solubility in H2O. Should be taken with an oil, such as fish oil capsules for best effect.

Gah...fucking shitbags. Just been raided, and the bloody cunts took my pramiracetam. I'll get it back of course, but in the mean time, my cognitive abilities have gone right back to shit, along with my memory.
« Last Edit: January 31, 2012, 11:41:15 PM by Tsathoggua »
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dream0n

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Re: Piracetam
« Reply #25 on: February 01, 2012, 12:12:02 AM »
:/ Again, do they ever leave you alone? It isn't like you advertise, or piss the porkers off?
off to bigger and better things - don't worry I will visit from time to time

Tsathoggua

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Re: Piracetam
« Reply #26 on: February 01, 2012, 01:16:11 AM »
It doesn't seem so. This time, they made some odd comments...that we (the family as a whole) could make this stop keep happening, if a social worker was got in.

Implying, that the decision to keep raiding has already been taken.
Nomen mihi Legio est, quia multi sumus

I'm hyperbolic, hypergolic, viral, chiral. So motherfucking twisted my laevo is on the right side.

fresh1

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Re: Piracetam
« Reply #27 on: February 01, 2012, 05:58:35 AM »
Quote
but the short-term memory thing would be remedied.

imo the memory 'loss' caused by cannabis is more due to not paying (or not being able to pay) sufficient attention to whatever the subject, for it to take hold in ones longer term memory.

its this effect which causes one to 'chill out' by getting stoned after an annoying event, as its difficult to stay focused on the event in question

fresh thinks being able to do this straight is a great thing, and can be 'learned' through awareness of this effect of cannabis

as a rule our memory stops us from repeating errors, alas its quite human to repeat behavior deemed successful, even when it's not

obsessive compulsion is the best example of this, as can be regular dope smoking, for as with any drug, a tolerance will develop due to the body's natural desire to maintain homeostasis

if one is looking solely for euphoria, cannabis may not be the 'best' drug ... and fresh LOVES his choof

I guess this depends on ones opinion of euphoric

its seems counterproductive to take drugs with the hope of neutralising a 'primary' effect of a drug

this is now commonplace in the medical community, particularly since the advent of SSR/NIs which cause so many varied (unwanted) side effects

this is EXACTLY as Big pharma likes (and wants) it

 self medication? Noooooooo!!! bad bad bad so we are taught ::)

Paxil (paroxetine) has been considered for some time now, to be the hardest known (prescribed) drug to stop

GSK shareholders have a billion dollar+ p.a.  smile all the way to the bank

its BEYOND fuckt

when I was a kid one had to be seriously fucked up to 'need' to be medicated, ADHD? ya gotta be jokin :o

 thats whats called being a Kid, and  bipolar(manic depressives) were as rare as rocking horse shit

nothing beats being straight, IF you wish to maintain optimum brain functions

and fresh wouldnt be here if he did ;D
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Tsathoggua

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Re: Piracetam
« Reply #28 on: March 19, 2012, 06:47:53 AM »
As cannabinoids act to reduce presynaptic neurotransmitter release, through activation of postsynaptic CB1 receptors inducing a retrograde signalling mechanism, to in essence reduce neurotransmitter release as a feedback mechanism, I imagine it reduces glutamate release and thus impairs LTP, leading to reduced memory formation/consolidation via less excitatory input to hippocampal neurons.
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Vesp

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Re: Piracetam
« Reply #29 on: March 19, 2012, 07:08:59 AM »
@Tsath - are you saying that piracetam might impair LTP? or just cannabinoids? I know piracetam does stuff with glutamate as well.. and when you say "it" in a piracetam thread it makes me wonder a bit?
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Tsathoggua

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Re: Piracetam
« Reply #30 on: March 19, 2012, 09:50:44 AM »
I was referring to cannabinoids.

I expect piracetam to do the opposite and improve LTP, as it has been shown to be a positive modulator at AMPA receptors, the main receptor responsible for fast excitatory synaptic neurotransmission.
Nomen mihi Legio est, quia multi sumus

I'm hyperbolic, hypergolic, viral, chiral. So motherfucking twisted my laevo is on the right side.

fresh1

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Re: Piracetam
« Reply #31 on: March 20, 2012, 06:10:46 AM »
I noticed you all seem to take multigram amount of these 'rams...is this necessary due to metabolic aspects or ?

Yes the retrograde mechanism of cannabinoids upon synapses is interesting, though IIRC aside from the temporary lowering of glutamate levels, this is not the prime reason for their effect on memory, which I dont think is yet clear

I think all the N-acylethanolamines are going to be found to have synergistic effects

That said, I highly doubt we have seen the last of CB1/2 series, with more receptors being found in time

If you look at the endogenous anandamide molecule compared to all the known cannabinoids it suggests much in vivo manipulation may occur to this big bugger, as to what, when and why, again I guess only more research will tell
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fatfreddy

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Re: Piracetam
« Reply #32 on: March 21, 2012, 12:03:21 AM »
Quote from: fresh1 on March 20, 2012, 06:10:46 AM
Yes the retrograde mechanism of cannabinoids upon synapses is interesting, though IIRC aside from the temporary lowering of glutamate levels, this is not the prime reason for their effect on memory, which I dont think is yet clear
There was just an article published that suggests cannabis' working memory deficits are caused by the CB type-1 receptor's effects on astroglial cells:

h++p://www.sciencedaily.com/releases/2012/03/120301143424.htm

h++p://www.cell.com/retrieve/pii/S0092867412001420

fresh1

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Re: Piracetam
« Reply #33 on: March 21, 2012, 06:16:00 AM »
Thanx fatfreddy nice one....I "guessed" as much so its always nice to valdidate ones own rambling ideas with some "genuine" research ::)

Suggests is such a hypothetical word though....hmmm I think this hypotheses needs work

  I often wonder if much "research" is too 'focused' on certain specific mechanisms of drug action/s and subsequently dont see the whole picture, after all (well at least in my opinion) this is a very complex molecular family, so to speak, which just like the enkephalin/endomorphin 'family' of ant/agonists and receptors, whose 'effects' are less cerebral and much more 'physical', and therefore much less susceptable to an "individuals"  idiosyncracies and opinions :P

Getting stoned on cannabis is an experience which is uniquely difficult to describe...ya know, the "hm am I stoned?" state through to the "I'm off my tits" state of stoned...how do you "describe" that to someone ho has never been stoned on cannabis? those trippy thoughts, that gentle euphoria...aaah!

I cant even explain it to myself ;D

I'm looking forward to more research

wssatm f1 :o

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delysiduous

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Re: Piracetam
« Reply #34 on: March 21, 2012, 07:56:48 PM »
I try to take between 1-3g per day.  Definitely notice an increase in certain cognitive abilities.  Also, as was mentioned, it tends to potentiate the effects of other substances.

Tsathoggua

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Re: Piracetam
« Reply #35 on: March 21, 2012, 11:38:42 PM »
Being an AMPA positive modulator, I wonder if they, or AMPAkines might increase opioid tolerance, sufficient AMPA receptor firing is known to be the prerequisite for the NMDA receptor to spit out its magnesium, and depolarize the cell, and NMDA receptor antagonists are known to be effective reducers of tolerance..also, 'racetams block, reduce or even terminate ket trips, and do a similar thing with MXE.
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fatfreddy

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Re: Piracetam
« Reply #36 on: March 22, 2012, 01:26:26 AM »
Quote from: Tsathoggua on March 21, 2012, 11:38:42 PM
'racetams block, reduce or even terminate ket trips, and do a similar thing with MXE.

I've seen this mentioned elsewhere (by the user "aniracetam" on this board, actually). However, it's important to remember that ketamine's primary psychoactive effect is actually caused by the fact that it agonizes AMPA receptors through downstream interactions. In blocking NMDA receptors, it causes the brain to release more NMDA. However, the AMPA receptors remain untouched and therefore get heavily agonized by this excess of unused NMDA. This effect has been found to cause the psychoactive effect as well as the excitotoxicity of ketamine. Here's the article that describes this effect:

hxxp://www.jneurosci.org/content/17/8/2921.full.pdf

There are many other similar sources; googling "ketamine AMPA" will provide them.

So, it may well be that racetams increase dissociatives' excitotoxicity, which isn't something to strive for. This is inference, but it's still something to keep in mind.
« Last Edit: November 17, 2012, 01:23:37 PM by fatfreddy »

livy

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Re: Piracetam
« Reply #37 on: August 17, 2012, 06:10:46 AM »
According to the experience of my friend in hospital, Aniracetam maybe more effective than Piracetam though it's cheaper than Piracetam.
But both of them need long term intake.

URL:http://www.ebiochem.com/product/aniracetam-98-19450

Tsathoggua

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Re: Piracetam
« Reply #38 on: August 17, 2012, 02:26:17 PM »
Bear in mind, that unlike many of the 'racetams; aniracetaam is fat soluble, when I used it I took it with fish oil capsules.

Of all the racetams, I have found pramiracetam to bee by far the best, although it is expensive.
Nomen mihi Legio est, quia multi sumus

I'm hyperbolic, hypergolic, viral, chiral. So motherfucking twisted my laevo is on the right side.

no_dream

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Re: Piracetam
« Reply #39 on: October 03, 2012, 12:17:40 PM »
Piracetam in modest dosages is not much working, but in combination with other agents like vinpocetine, cinnarizine it seems to reduce permanent headaches. Very little improvement in vigility, too.

Pyritinol is better i think.
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