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Author Topic: the kompot method of making heroin polish heroin  (Read 606 times)

jon

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the kompot method of making heroin polish heroin
« on: October 07, 2009, 02:59:19 AM »
anyone ever heard of polish heroin or kompot?
well these broke college students worked out a way to isolate alkaloids from poppy straw using acidic exchange resins probably polystyrene sulfonate or the like.
this method has advantages namely it  avoids the possible destruction of the alkoloids on evaporation of the water extract as the temps get to high for even a little while the morphine gets cooked (over 80 C) to psuedomorphine.
a link is here:
http://en.wikipedia.org/wiki/Polish_heroin
hey and the jonster just so happens to be a pole as well. seems like we have a common heritage
does anyone have any familiarity with exchange resins? seems compex.

Naf1

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Re: the kompot method of making heroin polish heroin
« Reply #1 on: October 07, 2009, 03:24:49 AM »
Extraction of morphine from poppy capsules and its recovery by ion exchange
C. L. Mehltretter, F. B. Weakley
DIGITAL OBJECT IDENTIFIER (DOI)
10.1002/jps.3030460315
Journal of the American Pharmaceutical Association
Volume 46 Issue 3, Pages 193 - 196
Published Online: 23 Sep 2006
Abstract
An efficient method for obtaining morphine from domestically grown poppies has been developed. Morphine was completely extracted from dried poppy capsules with water-saturated isobutanol containing 0.23% ammonia. By passage of the extract through a cation exchange resin bed, practically all of the alkaloid was adsorbed. Quantitative elution of morphine from the bed was achieved with dilute aqueous alkali. Crude morphine obtained by precipitation from the neutralized and concentrated eluate could be converted to pharmaceutical grade hydrochloride without difficulty. The overall recovery of morphine was 90%.

One of the best OTC sources of ion-exchange resin is companies that deal with water treatment.

jon

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Re: the kompot method of making heroin polish heroin
« Reply #2 on: October 07, 2009, 03:39:23 AM »
it seems like there are a lot of methods dealing with poppy straw that use ion exchange resins.
wonder why they use isobutanol it does'nt seem like that would be polar enough to penetrate through the celluotic plant matter.
it seems like the old school method may be a little more home chemist friendly.
using water that is.
so to recover your alkaloids off the exchange resins one would elute with dilute naoh makes sense
this would solvate the goods as the phenolate ion whereas in the original example they used ammonia it seems like that may kick it off the exchange resins but then there's solubility issues to deal with since morphine does'nt dissolve very well in plain aqueous solutions like that.
problem is in caustic mixtures like this morphine will dimerize at room temp in the presence of air.
so as an insurance policy trace nahso3 could be added to prevent this oxidation no?

Naf1

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Re: the kompot method of making heroin polish heroin
« Reply #3 on: October 07, 2009, 03:46:20 AM »
Usually plant material is extracted with 2-4% H2SO4, for this method. I dont exactly know why isobutanol (but you cant argue with their results!) The resin holds on to morphine, and base elutes it as you said.

Quote from this;
CODEINE CONTAINING FORMULATIONS
http://www.freepatentsonline.com/EP0781135.html

"With legitimate use of the product the anti-homebake ingredient is designed to release from the tablet and have no effect on the action or release rate of codeine. However, in vitro, the ingredients have specific properties which enable it to confound certain steps in the process of illicit codeine extraction."

Hmm, interesting!

Efficiency and Sensitivity of Two Common Screening Methods for detecting Morphine in Urine
http://www.clinchem.org/cgi/reprint/19/7/753.pdf

In the above they name and shame the offending exchange resin; Reeve Angel, N0. SA-2 (tis an amberlite cation exchange resin). Funnily enough they use the same method, and run a crude urine extract through a column of cation exchange resin. The resin in question has a stronger affinity for morphine than jon! And grabs and holds onto it with dear life (lol). Only to be freed into solution by an alkaline.

Naf1

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Re: the kompot method of making heroin polish heroin
« Reply #4 on: October 07, 2009, 03:58:40 AM »
AMINO ACID RESIN
Model:SA-2
Export area:ASIA Europe
Introduction:Appearance: amber spherical particle.
H.S CODE:39140000
Model:SA-2

This place has actually resin, whereas you would preferentially go for the amber spheres.

http://marketeo.com/en/Offer/suply-SA-2-amino-acid-specialpurpose-resin-388889.html

This is what it would look like;

That is not SA-2, but would look nearly identical.

jon

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Re: the kompot method of making heroin polish heroin
« Reply #5 on: October 07, 2009, 04:14:43 AM »
naf man you nailed it on the head
*The resin in question has a stronger affinity for morphine than jon*

Naf1

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Re: the kompot method of making heroin polish heroin
« Reply #6 on: October 07, 2009, 04:47:40 AM »
Lol, I do like a joke! :P

Thanks for bringing that one up, I had not heard of it before. Seems like an ingenious way to extract codiene from their anti-homebake pills, as well as if amino acids ever needed to be extracted from aqueous solutions. I think they use a different one for Ephedrine, but I would not be suprised if the SA-2 worked just as well with it.

jon

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Re: the kompot method of making heroin polish heroin
« Reply #7 on: October 07, 2009, 05:17:17 AM »
ya know swij and some other cat were  dicking around with loperamide swaping out the dimethylamido group for an ester and esterifying the tert alcohol and did'nt know what to call this stuff so i settled on jonorphine apt name ayyee?
well it turned out that proionoxy loperamide was interesting but a week later it was tried again and absolutely nothing happened so dissapointed after being in heroin heaven all weekend can only explain it away as it's affinity to p glycoprotein seems like it worked then nothing at all very strange indeed.

Naf1

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Re: the kompot method of making heroin polish heroin
« Reply #8 on: October 07, 2009, 05:54:42 AM »
Lol, jonorphine good name!

I though you were talking about making Darvocet initially. But swapping the amide for an ester? That is very interesting!

jon

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Re: the kompot method of making heroin polish heroin
« Reply #9 on: October 07, 2009, 06:37:38 AM »
just an acid catalyzed rxn done in alcohols  it works  on highly substituted amides pretty well, similar to an alcoholysis reaction.

jon

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Re: the kompot method of making heroin polish heroin
« Reply #10 on: October 08, 2009, 12:06:11 AM »
correction i used esters a-hydroxy esters because the calculated delta G is lower overall than alcohols since more bonds formed less broken principle this worked the end product was very short acting because of the orientation of that ester making it suseptible to in vivo hydrolysis in retrospect.

hypnos

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Re: the kompot method of making heroin polish heroin
« Reply #11 on: October 08, 2009, 03:18:54 AM »
 this sounds like a pretty cool extraction method for a variety of things--Reeve Angel, N0. SA-2---which is a (proprietary)  water de-ioniser--is also one of those urine screening compounds due to

  its affinity to several "hypnos friendly" compounds!!!!!!!!!!!!!!!!!!

    and yes it is pretty easy to get---just say(tho no one will ask,,but its good to know the "bullshit" just in case,,) when its for your "water broom" (aka.."tucker pole" from "Tucker Industries in d

    US) window cleaning" no drama
"the two things you can give away and never lose, are what you know, and how you feel...."

hypnos

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Re: the kompot method of making heroin polish heroin
« Reply #12 on: October 08, 2009, 03:28:23 AM »
"the two things you can give away and never lose, are what you know, and how you feel...."

flpx

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Re: the kompot method of making heroin polish heroin
« Reply #13 on: October 08, 2009, 05:40:53 PM »
I've got a quite good instructable how to make 'kompot' at home, I can translate it tomorrow for you guys if you really want  ;)
Though I cannot say anything about the chemistry of this process...


Cheers

jon

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Re: the kompot method of making heroin polish heroin
« Reply #14 on: October 08, 2009, 06:03:32 PM »
we would love to see that al lot of these  papers tend to leave out details assumming the reader is "skilled in the art"
it would be an intersting read
try systran software downloaded off limewire or such.
if it's pdf it's going to be a pain to translate i can tell you this much

Naf1

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Re: the kompot method of making heroin polish heroin
« Reply #15 on: October 09, 2009, 03:09:38 AM »
I just wanted to add as this discussion was about ion-exchange resin. Quote from Wiki;

"Ion-exchange resins are also used as excipients in pharmaceutical formulations such as tablets, capsules, and suspensions. In these uses the ion-exchange resin can have several different functions, including taste-masking, extended release, tablet disintegration, and improving the chemical stability of the active ingredients."

This would be a prime candidate for something added to confound the extraction process, as was done in the above patent concerning codeine formulations. Where they used this technique;

"The inclusion of additives in codeine-containing tablets, according to the invention, interferes with the homebake process by increasing the processing time and/or decreasing extraction efficiency. In particular, the additives may increase the time taken to filter the slurry and/or may emulsify the two phases in the liquid-liquid extraction step so that the separation of the two layers is inefficient.

In the case of a cellulosic film former or anionic surfactant, the ingredient chosen should be sufficiently water soluble not to be left behind in the solid phase as the codeine is dissolved when the crushed tablets are slurried up. The film formers interfere with the homebaking process by forming a gel when contacted with water, binding up the water phase and clogging up the filtration and also by inhibiting the solvent extraction of the codeine. The anionic surfactants work by emulsifying the solvent and liquid phases in the solvent extraction. The ion exchange resins are generally insoluble and lock up the codeine so that it cannot be extracted.

The inclusion of 2.5% by weight of hydroxymethylpropyl -cellulose in the tablet formulation according to the invention has been found to reduce the extraction of codeine by approximately 45-65%. Sodium lauryl sulphate has been found to reduce the extraction by approximately 25% when incorporated at 0.9% by weight, and by greater than 90% when incorporated at 2.5% by weight. Of the ion exchange resins tested, Zeolex 23A and Amberlite IRP69 (a styrene based sulfonic acid cation exchange resin) gave very good results, both reducing codeine extraction by approximately 60%.

It is strongly preferred that the anti-homebake ingredient be distributed throughout the matrix of the tablet, to reduce the possibility of physical separation of the ingredient prior to the homebake process. "

To take a quote from that snippet;

"Of the ion exchange resins tested, Zeolex 23A and Amberlite IRP69 (a styrene based sulfonic acid cation exchange resin) gave very good results, both reducing codeine extraction by approximately 60%."

Not if you know its in there dummies!

jon

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Re: the kompot method of making heroin polish heroin
« Reply #16 on: October 09, 2009, 04:17:05 AM »
got to hand it to naf he's an excellent researcher.
a lot of folks in the land down under seem to be getting around %50 of codeine from thier extractions this may explian it since this is where the homebake process is most often used.

Naf1

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Re: the kompot method of making heroin polish heroin
« Reply #17 on: October 09, 2009, 05:04:34 AM »
Yes if I were them I would be basing the filtered solids, to recover the other 50% Or better yet crushing the pills and adding more exchange resin(say for 1 gram of pill mass/ 1 gram of exchange resin),the extra exchange resin would absorb the rest of the codeine and provide a nice support so the gel that forms wont clog up the filter. And pouring in some household vinegar. Stir, and filter and discard the liquid, add an aqueous basic buffer to release the codeine and stir and filter out the solids and discard them. You could evaporate that solution to dryness, and preform a solvent extraction, and/or recrystallization?? But after evaporation I bet you have better yields of cleaner (non acetaminophen) product than ever imagined.

I must admit the majority of the people down here rarely go to the trouble of extraction, they just do the old bread basket extraction. Which is quite dangerous as their pill of choice seems to be Nurofen Plus, that is predominately acetaminophen with a small amount of codeine. Acetaminophen (paracetamol) destroys your liver when taking large and sustained doses!
Edit; It is actually ibuprofin in Nurofen plus, shows you how many I take!

Nurofen plus the hidden drug scourge
http://www.news.com.au/story/0,23599,23022299-1702,00.html


« Last Edit: October 09, 2009, 05:13:04 AM by Naf1 »

flpx

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Re: the kompot method of making heroin polish heroin
« Reply #18 on: October 09, 2009, 05:58:29 PM »
Quote from: jon on October 08, 2009, 06:03:32 PM
we would love to see that al lot of these  papers tend to leave out details assumming the reader is "skilled in the art"
it would be an intersting read
try systran software downloaded off limewire or such.
if it's pdf it's going to be a pain to translate i can tell you this much
Well, this is not an official paper, just a how-to for people who wanna make kompot without the need to know chemistry. I hope you can guess what chemical reactions happen in each step; I'm just a student (I learn more than talk) and would not dare to say anything about the chemistry of this process without any experience.

This is the translation, word for word, I hope without any bigger mistakes:

The core process is the acetylation of morphine alkaloids to heroin using acetic anhydride.

Things you will need:
-poppy straw,
-ion-exchange resin (brown-gold coloured grains, used as a fill in water softeners; you can obtain it at boiler house or in aquaristic shops. There are different kinds of this resin, you will need the acidic one),
-vinegar 10%,
-kitchen salt,
-25% ammonia water,
-acetone (ether is better but harder to get),
-acetic anhyhdride  (hard to get; people used to steal it from hospital's laundry),
-a few saucepans, bowl/basin, electric cooker or iron, dropper.

First of all, put 2-3 kg of ion-exchange resin in a dish and pour a bottle of vinegar into it, then add 1kg of kitchen salt. Add some water so the resin is filled to the top, then stir.
You can soak the resin in HCl but vinegar is cheaper and easier to obtain. It must soak for some time, you can stir from time to time with something made out of wood. You can also gently heat, but avoid boiling.

Now it's the "soup" part. To 20 litre saucepan put poppy straw, fill with water and boil. Press (knead? pinch?) it while boiling. Water will become brown. Strain (filter) it and leave only the liquid (remove all solid things).

Strain (filter) the ion-exchange resin and carefully rinse with water. If the resin was soaked in HCl, you have to rinse very carefully and precisly.

Put the ion-exchange resin in a bowl/basin and pour the filtered "soup" on it. It must soak for a few hours, longer=better, approx. 3-5 hours. You have to stir, because the ion-exchange resin is heavy and will descend to the bottom. Don't heat. The resin is absorbing opiates.

Then strain (filter) the soup from the upper part and throw it away (you can flush it in the toilet). The soup is sweet, because the resin took all bitterness.
You have to put the ion-exchange resin in a new saucepan and fill with water (only to cover the resin + 4-5cm more over the resin). Add 250-300ml of 25% ammonia water to the saucepan. Then, while stirring, boil it for 5-6 minutes.

When the water becomes darker, you have to strain (pour) it to some container and keep. It is the first fraction - the most powerful. You have to pour water again on the resin, add ammonia water, boil and pour another fraction to another container. It can be repeated for 10 times, the last fraction has a light-straw colour (like urine? ;). You should not mix the succesive solutions.

Now you have to evaporate water from every fraction. You can do it in a saucepan. It's gonna leave a pitchy (like tar) substance on the bottom of the saucepan. It's called (the tar-like substance) a "plaster" or "honeycomb". It should be entirely dry, you have to care and check not to burn it.

The plaster (or "honeycomb") can be washed with ether or acetone. Add some acetone to the saucepan to dissolve the plaster, the rest of it take with some cotton wool soaked with acetone. Everything has to be put in one dish.

Now you have to vaporize acetone from the plaster on an electric cooker or iron.

When the most of acetone is vaporized, but not the whole acetone, you have to add 5-6 drops of acetic anhydride (using a dropper) to the dissolved plaster.
The plaster has to be vaporized until it is entirely dry, because acetic anhydride is a poison.

What is left dissolves in small amounts of water, approx. 20-30 cm(3). It is the "kompot".

The whole production has a specific smell.
------

I hope this will be useful to any of you...I'm not the author of this text, it is written by people who once produced kompot in Poland...

There is also a very simple method of heroin production from opium (from poppy). I can also translate it if you want.

jon

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Re: the kompot method of making heroin polish heroin
« Reply #19 on: October 10, 2009, 03:35:05 AM »
Now you have to evaporate water from every fraction. You can do it in a saucepan. It's gonna leave a pitchy (like tar) substance on the bottom of the saucepan. It's called (the tar-like substance) a "plaster" or "honeycomb". It should be entirely dry, you have to care and check not to burn it.


i refer you all to this:

http://books.google.com/books?id=qw4P5AABgmEC&pg=PA605&lpg=PA605&dq=morphine+degradation+pseudomorphine&source=bl&ots=7AGQoFbolB&sig=4gYuZU4a55ygjgy4mBTLabPtD8A&hl=en&ei=T_vPSr62N8vf8QbQgYn_Aw&sa=X&oi=book_result&ct=result&resnum=8&ved=0CB8Q6AEwBzgU#v=onepage&q=morphine%20degradation%20pseudomorphine&f=false

anytime someone intends to evaporate an aqueos solution of morphine optimal ph is 3.2

between ph 5.5-7 the rate at which morphine converts to inactive psuedomorphine dimer increases exponentially especailly with heat.

so there's one hole in that process.
anyone care to shoot more????
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