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Author Topic: Mephedrone via p-xylene  (Read 107 times)

Happyman

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Mephedrone via p-xylene
« on: December 25, 2009, 07:55:25 AM »
Like most of my threads this starts off with some guy (nomud) on Wetdreams says...

Starting from p-xylene, by distilling commercial xylenes.p-xylene distills over first fraction by 1 degree C less than m-xylene.p-xylene is about 18-20% of commercial m,o,p-xylenes.Luckily, this fraction will crystallize in a stoppered flask in the freezer,in an hour or two,pour off any remaining liquid and recryst.repeat,redistill,repeat for 99% p-xylene.Figure swiy's mole eq. wt. and proceed to bromination of ring with mole eq. Br2 and pinch of iron powder as cat,or possibly Br2 in AcOH [in dark].For monoBromo p-xylene.Then a Friedel Crafts propionylation w/ either propionic acid,or anhydride or propionyl chloride, swiy's choice of cats. and reagents.To yield the 4-Br 2,5-dimethyl propiophenone.The alpha carbon-ketone halogenation is done w/ chlorine water.Then methylamineate to title substance.Mephedrone seems to have some toxicity,likely due to the mono-paramethyl group,as does p-methoxyamphetamine.This should be smoother and less toxic,more potent.And almost as easy a synth..Swim will likely test on pet gorilla next month
http://www.drugs-forum.com/forum/showthread.php?t=93427

So 4-Bromo 2,5-dimethylpropiophenone is that right? Can I also get a paper on carbon-ketone halogenation? Is it just halonating a ketone with a carbon bond? Also why can you use regular propionic acid instead of propionyl chloride? I don't know what that is so I am having trouble visualizing this whole reaction. My current guess is...
2C8H10+Br2--->2C8H9Br+H2
C8H9Br+C3H6O2--->C11H13BrO+H2O
And here is my big question mark.
C11H13BrO+CH5N--->C11H15NO+CH3Br

I also drew a pretty picture
« Last Edit: December 25, 2009, 08:19:37 AM by Happyman »

Vesp

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Re: Mephedrone via p-xylene
« Reply #1 on: December 25, 2009, 08:45:11 AM »
Perhaps not how you'd like this thread to start off, but if it is only by one degree, it will be very very difficult to separate it by distillation.. so consider using another method to separate the xylene... such as freezing/melting points - the p-x and the others seem to have a significant difference... however you'd need to do it several times in order to get it significantly pure.
Another method of purifying it is perhaps later on in the reaction when the isomers/other compounds that form because of the other xylene present are more easy to separate based on boiling point, solubility, melting point, etc.

Also it looks like you'd be wanting to remove the methyl groups? That would be difficult with out seriously messing up some other stuff... as far as I know at least.. but it isn't really obvious what is going on in that reaction to me because it is late...
« Last Edit: December 25, 2009, 08:48:00 AM by Vesp »
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Enkidu

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Re: Mephedrone via p-xylene
« Reply #2 on: December 25, 2009, 08:50:26 AM »
The product of the second rxn is wrong. You accidentally moved one of the methyl groups around on the ring. You never make mephedrone from this 'recipe,' you simply make the beta-keto 3C-B [Edit by Enkidu - it's actually 2,5,n-trimethyl instead of dimethoxy, so not quite 3C-B. The product would be 2-(methylamino)-1-(4-bromo-2,5-dimethylphenyl)-propan-1-one]. Dunno why he [the original poster at DF] even brings up mephedrone....  he obvisouly has no fucking clue about the pharmacological properties of the substances he is discussing.

Edit: nice try with chemsketch though!  ;D
« Last Edit: December 26, 2009, 07:26:25 AM by Enkidu »

Enkidu

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Re: Mephedrone via p-xylene
« Reply #3 on: December 26, 2009, 06:33:57 AM »
====> Trash

Vesp

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Re: Mephedrone via p-xylene
« Reply #4 on: December 26, 2009, 07:01:40 AM »
And we'll be more nice here... won't we Enkidu?
We're all learning, and if you happen to have the time to call him out on what he knows and doesn't know, edit your posts, and come back to trash the thread - you might as well just tell him where he has made the mistake, right? Maybe give helpful tips on understanding organics?.. point him in the right direction?
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Enkidu

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Re: Mephedrone via p-xylene
« Reply #5 on: December 26, 2009, 07:29:55 AM »
Sorry Vesp, I hope that my post was not interpreted as calling the OP of this thread out. However, the information in the thread does need to removed (soon) as to not confuse the search engine. You cannot make mephedrone from p-xylene using a method anywhere close to this. I incorrectly identified the proposed product in my first post, and so I edited to make it clear what the product is. (I think I finally got it fucking right.)

If you notice the drugs-forum thread is titled "4-Br 2,5-dimethyl n,methcathinone" and then he (the DF OP) talks about making the "title substance."

I think that the OP of this thread can figure things out on his own from here. He was just confused about how the DF OP got to mephedrone!

Vesp

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Re: Mephedrone via p-xylene
« Reply #6 on: December 26, 2009, 07:42:17 AM »
Yeah, its fine, it just sounded harsh and I don't want to scare people off from contributing is all..
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