60-80mg of the recrystallized stuff is enough to make me poop. i generally like 150mg as a full dose, loving the world, bright eyed and bushy tailed. for me a small dose is like 40-60mg, can function perfectly fine and a nice buzz. slight euphoria, a little warm, and light roll buzz at 40mg / strong warmth radiating from the chest and a definite mild roll at 60mg / eye wiggles getting uncontrollable at 80mg with the strong want to take more for a full-on experience. the low dose for me there's no tweaking but definitely takes away fatigue, makes the day feel special and memorable. i've taken small amounts while sick from a cold and all symptoms went away for a couple hours. nasal congestion was gone, aches/pains were relieved, etc, felt better than normal for sure.
the most i've ever done was a little over a gram like 1.2-1.5g but was spread out over 3 days. it was a bit much and i'd never repeat that, i felt like i was living in a very very light acid trip for a week afterwards plus those damn headaches.