Author Topic: Halogenated amines, ethyl/propyl alpha chains and beta methyls.  (Read 88 times)

Naphyrone

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Halogenated amines, ethyl/propyl alpha chains and beta methyls.
« on: April 16, 2010, 07:50:07 AM »
Long time no post  :D

So iv'e been sitting here thinking of what a utopia the us is at the moment for all the new RCs.
Figuring it probably won't last forever, I have had some interesting ideas.

Currently most stimulant/euphoriant RCs are methcathinone derivatives, this is good and all but if a certain 4 position one were to get scheduled then no more positional isomer derivatives. :/
However noting that a longer alpha chain increases dopamine activity while decreasing NE activiy and beta methyl phenethyl amine having a high NE activity with almost no(if any) DA activity along with the effect of lengthening metabolism i beleive a compromise could be made theoretically between the two positions to increase dopamine while keeping some NE activity and a longer life with a possible higher absorption than the methcathinone derivatives. Seeing that Fluro tends to be a very good substitute for methyl you could possibly increase activity with an N-fluro while further removing it from it's amphetamine relative. This could theoretically be the next base for possible future RCs IMO.(throw a methyl/bromo/fluoro on that 4 ???)

pic attached for better visualization.
« Last Edit: April 16, 2010, 07:53:57 AM by Naphyrone »

Enkidu

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Re: Halogenated amines, ethyl/propyl alpha chains and beta methyls.
« Reply #1 on: April 16, 2010, 09:10:54 AM »
That one could very well be a nasty neurotoxin. And that fluoramine... wut? I don't think I'd be interested in eating any halogenated amine....

Naf1

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Re: Halogenated amines, ethyl/propyl alpha chains and beta methyls.
« Reply #2 on: April 16, 2010, 11:14:46 PM »
"Currently most stimulant/euphoriant RCs are methcathinone derivatives,"

No they are not, the cathinones mephedrone specifically was targeted by this latest law from the list below (not a full list either) there are about 2 cathinones!

I think the new replacements have already been introduced, the stocks of mephedrone have been sold after the new law was passed a couple of days ago. You can still find the cathinones but the majority are the dodgy dealers and places where they can get away with it (like China). If you were still looking, there still is a lot of produce on the shelves that have been around a while but are about to be shifted to the front of the shelves;

Naphyrone
Buphedrone,
2,5-dimethoxy-4-iodophenethylamine(currently scheduled in Europe),
Dimethocaine,
5-MeO-DALT,
Methylenedioxypyrovalerone,
5,6-Methylenedioxy-2-aminoindane,
Flephedrone,
alpha-Pyrrolidinopropiophenone,
3',4'-Methylenedioxy-alpha-pyrrolidinopropiophenone,
3',4'-Methylenedioxy-alpha-pyrrolidinobutiophenone,
4'-Methoxy-alpha-pyrrolidinopropiophenone
4'-Methyl-alpha-pyrrolidinopropiophenone
Butylone (was that scheduled with mephedrone on April 12th? )
Methylnaphthidate
these have already started popping up, 2C-BCB and Jimscaline,
of course the synthetic cannabinoids will be available in some guise or another, some with strong analgesic activity.

I could seriously keep going for some time, and we have not even got into prospectives (besides Jimscaline).  
« Last Edit: April 16, 2010, 11:19:57 PM by Naf1 »

Enkidu

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Re: Halogenated amines, ethyl/propyl alpha chains and beta methyls.
« Reply #3 on: April 16, 2010, 11:40:42 PM »
plus, that beta methyl will probably abolish recreational effects.

Naf1

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Re: Halogenated amines, ethyl/propyl alpha chains and beta methyls.
« Reply #4 on: April 17, 2010, 12:58:28 AM »
"2-Phenly-3-aminobutane forms a colorless to slightly colored mobile liquid with an amine like odor, and acrid burning taste. It
is similar to amphetamine in its toxicity, CNS stimulation, rate of effects, and detoxification. However, it is more effective then
amphetamine in fighting symptoms offatigue, and depression. It has a boiling point of90 Celsius under a vacuum of 14
millimeters of mercury, and it is soluble in alcohol and ether with low solubility in water- the liquid is highly soluble in acids
forming acid addition salts. Note: This is a controlled substance (stimulant) as listed in the US code of Federal"

Ledgard, Laboratory history of Narcotics. Also pp 227 Otto Snow love drugs.

"para-Chloroamphetamine (PCA), also known as 4-chloroamphetamine (4-CA), is an amphetamine derivative and monoamine releaser similar to MDMA, but with substantially higher neurotoxicity, thought to be due to the unrestrained release of both serotonin and dopamine as with MDMA itself.[1] It is used as a neurotoxin by neurobiologists to selectively kill serotonergic neurons for research purposes, in the same way that 6-hydroxydopamine is used to kill dopaminergic neurons.[2][3][4][5]
This compound does have a history of being used daily as an antidepressant with no mentionable side effects that are particularly worrysome in humans. However, the effects of the compound on experimental animals appear less encouraging"

Wiki

N-fluoroalkylated phenylethylamine
United States Patent 3911016

Fluoroalkylated phenylethylamine derivatives are prepared having the formula ##EQU1## where Alk is an alkylene group having 2 to 6 carbon atoms, R1 is hydrogen or methyl, R2 is hydrogen or hydroxy, R3 is hydrogen, halogen, hydroxy, trifluoromethyl, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, m and n are integers of 1 to 3 as well as acid addition salts thereof. The compounds are useful in weight control.

http://www.freepatentsonline.com/3911016.html
« Last Edit: April 17, 2010, 01:06:11 AM by Naf1 »

Naphyrone

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Re: Halogenated amines, ethyl/propyl alpha chains and beta methyls.
« Reply #5 on: April 17, 2010, 02:33:58 AM »
Thanks for the info naf1, still would like to test the compound and variants on mice just to know the effects of the fluorinated amine. Enkidu, i think the beta-methyl would increase the recreational effects by inhibiting mao while decreasing metabolism, especially after reading Naf1's post. However the alpha chain should probably be an ethyl or propyl considering that the beta increases NE release, the lengthening would lower the effect but help with DA. That para-bromo is scary indeed, maybe a 3-methoxy-4-methyl variant like MMA would be better.

Enkidu

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Re: Halogenated amines, ethyl/propyl alpha chains and beta methyls.
« Reply #6 on: April 17, 2010, 03:19:14 AM »
Thanks for the info naf1, still would like to test the compound and variants on mice just to know the effects of the fluorinated amine.

The fluorinated amine is nasty.. Naf's ref is for an alkyl fluorinated compound, not an amino fluorinated compound. Fluorine is well known as a hydrogen replacement that staves off metabolic attack.

I didn't realize that the 2-amino-3-phenylbutane is active, and even scheduled. Nice!

Naf1

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Re: Halogenated amines, ethyl/propyl alpha chains and beta methyls.
« Reply #7 on: April 17, 2010, 05:47:15 AM »
You are right, but N-flouroalkylated phenethylamines look like the shit ;D How come I have never heard of them either!

"That para-bromo is scary indeed"

Yes it did sound worrying but then there were comments like this in wiki for para-chloro amphetamine;

"This compound does have a history of being used daily as an antidepressant with no mentionable side effects that are particularly worrysome in humans."

http://en.wikipedia.org/wiki/Para-Chloroamphetamine

Naphyrone

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Re: Halogenated amines, ethyl/propyl alpha chains and beta methyls.
« Reply #8 on: April 17, 2010, 06:01:04 AM »
i heard 4-bromo-methcathinone is suppossed to have more of an anti-depressent effect and less of a stimulant effect unlike it's brother mephedrone.