I have a patent that outlines two routes to M_eth from amphet (sulphate) but i have no idea if they would work - i did hear a rumor that they contained errors - i do not have the chem training to establish for myself the validity of the patent.
could the more enlightened here let me know if in theory they are good routes?
i dont know how to post a pdf file but i can send pm if anyone is willing to assist.
Here is one section that should be a familiar procedure:
Quote:
Formaldehyde and Aluminum Amalgam
N-Methyl-amphetamines were prepared by the reaction of the corresponding amphetamine with formaldehyde and reduction in the absence of acid. Thus, a mixture of 1 mole amphetamine freebase (136g) and 1 mole aqueous formaldehyde (81ml 37% or 75ml 40%) in 350 ml alcohol and an excess of aluminum amalgam was reduced for several hours, water added, aluminum hydroxide filtered off, the solution acidified and evaporated, and the freebase separated by means of alkali yielding phenyl-N-methylisopropylamine, converted to the hydrochloride, mp 140°C. Similarly, 70g d-amphetamine in alcohol with aluminum and 1 mole formaldehyde gave d-methedrine, which was converted to the phosphate salt. 1-Phenyl-2-aminopropanol similarly yielded ephedrine.
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