Acetate instead of hydrochloride salt?

Harmonia · Tue Aug 09, 2005 4:37 am

Is there any specific reason for creating the hydrochloride salt for example 2C-I/2C-B? Or could the acetate be made as well, simply by dripping glacial acetic acid into the freebase dissolved in toluene/etc (don't have access to sulphuric acid, so the sulphate is out of the question)? I don't like to huff the HCl gas, tears my lungs and throat up. Very Happy

Elementary · Tue Aug 09, 2005 5:06 am

I can't see any problem with an acetate salt, it works for amphetamine. It may turn out to be more hydroscopic than the hydrochloride though.

ApprenticeCook · DILLIGAF

Hydrochloride salts have great stability, the stronger the acid the stronger the salt, acetates would be weaker salts of organic bases and would be susceptible to decomposition before the HCl salt. Just take care of the product a bit more and it will be fine, ie heat and any basic conditions both of which will produce decomposition. So take care when drying the crystal product.

-AC

Harmonia · Tue Aug 09, 2005 2:11 pm

Many thanks!
Also, maybe titration with conc. HCl would be an alternative for example 2C-B since the 2C-B.HCl isn't very soluble in water? Titrate till neutral, filter of the crystallised 2C-B, then separate layers, put in freezer and se if anything else falls out.

icecool · Insistent Chemist

How come that 2CB.HCl isn't really water soluable and normally HCl salts are very hygroscopic?

bio · Working Bee

....acetate be made as well, simply by dripping glacial acetic acid into the freebase dissolved in toluene/etc .............

Joe did this a while back with the unsubstituted methylated product and expected crystals to drop out. GAA 99.7% RA (ACS) was used as is and the PhMe was recently distilled RA grade. Nothing precipitated so a water extraction was resorted to. Was a bitch to dry but wasn't really much more hygroscopic than the HCl salt. Had a similar taste not quite as bitter and very little nasal burn.

Your acetate amine may of course have different solubility properties but mine seemed to be somewhat soluble in everything I tried even the benzene & toluene. Hexanes are much better for this purpose. I suppose this is not too surprizing considering it's an organic acid salt and yes, acetic acid is miscible with damn near everything.