NP washes to remove acetaminophen from codeine

Buckshot · Tue Sep 06, 2005 11:14 am

Can SWIB use a regular NP that isnt chloroform to wash tylenol out of codeine?

Or can an acid/base be done on T1's or T3's? of course after a cold water pull.

What about a presoak in a easy to obtain NP before a cold water.

Or can anything be done to seperate the two, that is simple other than a cold water....or after the coldwater extract?

Im asking becasue where I live in Canada we can get bottles of 200 8mg T1's for under $10. But thats really alot of tylenol.

Thanks

java · Consumer

Codeine Physical properties....

PHYSICO-CHEMICAL PROPERTIES

3.1 Origin of the substance

Codeine is obtained either naturally, from opium (extracted
from Papaver somnifera) or by methylation of morphine.

It is a phenanthrenic alkaloid and constitutes 0.5% of raw
opium.

3.2 Chemical structure

Molecular formula

C18H21NO3

Molecular weight

Codeine base (anhydrous) 299.36
Codeine base (monohydrate) 317.4

Structural names

7,8-Didehydro-4,5-epoxy-3-methoxy-17-methylmorphinan-6-ol.

(5alpha,6alpha)-7,8-Didehydro-4,5-epoxy-3-methoxy-17-
methylmorphinan-6-ol.

3.3 Physical Properties

3.3.1 Properties of the substance

3.3.1.1 Colour

Codeine base

Colourless (crystals) or white (powder)

3.3.1.2 State/Form

Codeine base

Crystals or a crystalline powder

3.3.1.3 Description

Codeine base

Odourless
Bitter taste
Melting point is 154°C to 158°C
Effloresces slowly in dry air
Affected by light
Soluble 1 in 120 of water in 15 of boiling
water, in 2 of alcohol, in 0.5 of chloroform,
in 50 of ether.
Soluble in aryl-alcohol and methyl alcohol.
Very soluble in dilute acids, slightly soluble
in a excess of potassium hydroxide solution.
pH of more than 9 in a 0.5% solution of codeine
in water. pKa 8.2 (Casarett & Doull, 1980).

............source, http://www.intox.org/databank/documents/pharm/codeine/codeine.htm#SubSectionTitle:3.3.1%20Properties%20of%20the%20substance

---------------------------------------------------------

1.1 Substance

Paracetamol (tylenol)

1.2 Group

1.3 Synonyms

4-Hydroxyanilid kyseliny octove;
Abensanil; Acamol;
Acetagesic; Acetalgin;
Acetaminofen; Acetaminophen;
Algotropyl; Alvedon; Amadil;
Anaflon; Anelix; Apamid;
Apamide; APAP; Ben-u-ron;
Bickie-mol; Calpol; Cetadol;
Clixodyne; Datril;
Dial-a-gesic; Dirox;
Dymadon; Eneril; Excedrin;
Febrilix; Febro-gesic;
Febrolin; Fendon; Finimal;
Hedex; Homoolan; Lestemp;
Liquagesic; Lonarid; Lyteca;
Lyteca syrup; Multin; NAPA;
Napafen; Napap; Naprinol;
NCI-C55801; Nobedon; Pacemo;
Panadol; Panets;
Paracetamole; Paracetamolo;
Parmol; Pedric; Phendon;
Pyrinazine; SK-Apap;
Tabalgin; Tapar; Temlo;
Tempanal; Tempra; Tralgon;
Tussapap; Tylenol; Valadol;
Valgesic

1.4 Identification numbers

1.4.1 CAS number

Physical properties

3.3.1 Colour

White

3.3.2 State/Form

Solid-crystals

3.3.3 Description

Melting point 169 to 170.5 Solubility in water: very slightly soluble in cold
water but greater solubility in hot water.
Solubility in organic solvents: soluble in methanol,
ethanol, dimethylformamide, ethylene dichloride,
acetone, ethyl acetate. Slightly soluble in ether.
Insoluble in petroleum ether, pentane, benzene.
(Budavari, 1996).

.......source,
http://www.inchem.org/documents/pims/pharm/pim396.htm#PartTitle:3.%20%20PHYSICO-CHEMICAL%20PROPERTIES
-----------------------

So just go throught the list and figure what you can use to isolate your desired product......java

gomer · Wed Sep 07, 2005 12:53 pm

For some reason smartasses around here dont like to help newbees so I dont know alot but i will try. Rolling Eyes

The other solvent which u might find easier to get is DCM(dichloromethane aka Methylene chloride)Do your cold water crap and filter and such and then bring the ph up to about 12 using a solution of 2 tablespoons caustic soda with 200 ml of water.Add some of this to your mixture of codeine,water and paracetamol until the ph is 12.Once on 12 just add about 30-40ml of DCM and wash it through by turning upside down several times and shaking gently making sure to vent after each tumble as a bit of pressure builds.Remove the DCM and then repeat the process 2 more times with fresh DCM.The codeine should now be in the DCM and the para is in the water.Seperate all the water from the DCM and I mean ALL THE DAM WATER and then put the DCM in a ceramic bowl ontop of a pot of simmering water and slowly evap down with gentle heat and you will be left with your codeine.