n-methyl-phenylisopropylamine from p2np?

brain · Linguist Extraordinaire

sorry if i breaked the rules ? but i have to ask some questions!
I wont to obtain n-methyl-phenylisopropylamine hcl in one step sythesis from p2np.

p2np+nitromethane+Al/Hg (3 bar presure)->p2p+methylamine->methedrine hcl?? newbee questions...

1)will p2np react with Al/Hg to give p2p? hydrogenation~reduction
2)will p2np react with methylamine (from nitromethan-Al/Hg)
3)cant the presure be higher than 3 Bar ?? will it hange the yeld?
4)will be better to obtain first p2p from p2np? with~ SnCl2 etc. -if it is not neccesery-i dont wont to do this...
5)will p2np react with nitromethane?
-if the amphetamine will be produced, can andd some formaldehyde on the end of reaction, and some more Al/Hg ?? will make methedrine hcl?

IndoleAmine · Dreamreader Deluxe

Please don't do it, it is illegal and will probably bring you into jail for a long time.

Generally, it is not good to do several reactions in one pot at the same time, so it would be better if you made the phenylacetone from the p2np before reductively aminating.

Same thing goes for methylation with formaldehyde: can be done with Al/Hg, but better not one-pot with a p2np reduction.

The result of a pressurized al/Hg with nitromethane on p2np could be interesting though Shocked

- but as said already: unless you have a permission to do such experiments (and I doubt you have one Very Happy

), you really shoudn't attempt anything like that.

(and I was joking about it being "interesting": you will probably blow yourself up, and your whole house too!)

i_a

brain · Linguist Extraordinaire

hm, I can have that kind of permission Smile

... hm, not me-my friend, but nobody will gues Wink

-sheety

.... I heve to make:
1-p2p from p2np
2-methylamine*HCl from nitromethane

-hope will not explode Smile

-can I use higher pressure?

IndoleAmine · Dreamreader Deluxe

for making methylamine, you don't really need pressure. Just do an Al/Hg with only nitromethane and alcoholic solvent, and collect all evolving gases into icecold alcohol. When finished, decant the alcohol from the Al/Hg sludge as far as possible, and combine it with the alcohol used for catching the escaping meAm gas.

You now have an alcoholic solution of methylamine, ready for the next Al/Hg - simply pour the alcohol/MeAm soln. over fresh Al, let amalgamate and add ketone.

I'm not sure, but I think if your apparatus can hold more than 3bar, then it could be of advantage. But pressurized (glass?) vessels are dangerous, so don't overdo it here.

And for better yield and less exothermic reaction, you could form the imine beforehand, by adding the ketone to your methylamine containing alcoholic solution, adding enough drying agent to take up all water that will form (as drying agent, you can use almost everything that is inert to alcohols, amines and ketones - silica gel, molecular sieves, Na2SO4 etc.), wait until the imine has formed (color changes to darker yellow/brown), and then add the alcohol/methylamine/imine solution to your preamalgamated Al. (just an idea)

and make sure you use a big excess (like 5x molar) of methylamine, and make sure you get that grant before attempting any synthesis! Very Happy

i_a

Chaoslord · Thu Jun 23, 2005 7:38 pm

Question Add-on - Can't LiAlH4 be used to that effect? B-Phenyl-B-Nitropropene to amphetamine?

If so, how?

Articles are somethins difficult to get access too....

joe_aldehyde · huxleys associate

of course it can, chaoslord. and it's not true you can't get access to the respective articles. LAH reductions are standard procedure. why don't you do a bit of googling?

Chaoslord · Fri Jun 24, 2005 4:22 pm

Googling is very unforgiving in terms with chemistry, more than anything else, joe Wink

I do tend to search quite a bit , and after a while of no luck I tend to ask for a more
"certified" answer, and in the future it might help others, will it not?

While searching for it, I found that Red-Al would also do the job
(I don't know how well it will do it, but i's time to start trying some nice experiments)

I am not asking anyone to do my work for me, but sometimes pointing in the right direction would help, save some time, and some headaches

Otherwise, what is the point of a community if there is there is no mutual help?

Cheers

EDIT : After carefull searching, I think that both LAH and RedAl tend to be a bit expensive for that particular use - I wonder if there is a NaBH4 reaction somewhere that does the same job...

joe_aldehyde · huxleys associate

not NaBH4 alone, but NaBH4 followed by Zn/HCOO*K/NH4/H reduction. it's out there...