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Klot

Joined: 14 Feb 2005
Posts: 93
581.06 Points

Mon Mar 21, 2005 3:21 pm
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Может быть эта тема более уместна на энтеогене но так как у нас тут и фармакология обсуждается то думаю можно

Встретил на хае вот этот топик про сабж
http://www.behigh.org/inv/index.php?act=ST&f=3&t=28218&s=580f32d6a58a0dc61ddf9c7d632655cd

Там говорится что это обладает стимулирующим свойством и не вызывает тахикардию
Заинтересовался провел поиск (быстрый очень как позже выяснилось , так как статей очень много могу все не охватить. И оказалось весьма достойная тема для изучения

Ну сперва абстракты статей что нашел , найду больше выложу еще

Effects of alcohol aqueous extract from Rhodiola rosea L. roots on learning and memory.

Petkov VD, Yonkov D, Mosharoff A, Kambourova T, Alova L, Petkov VV, Todorov I.

The effect of alcohol-aqueous extract (1:1) from Rhodiola rosea L. roots on the processes of learning and memory is studied on rats. Several methods of active avoidance with negative and positive reinforcements are used, as well as of passive avoidance. Using the maze-method with negative (punitive) reinforcement, it has been found that Rhodiola extract in a single dose of 0.10 ml per rat essentially improves learning and retention after 24 hours. Significant improvement of the long-term memory is also established in memory tests after 10-day treatment with the same dose of the extract. In the other two doses tested (0.02 and 1.0 ml per rat) the extract has no substantial effect on learning and memory. In a dose of 0.10 ml per rat the Rhodiola extract had a favourable effect on the training process using the "staircase" method with positive (food) reinforcement as well. With the other methods used (active avoidance method with negative reinforcement "shuttle-box" and passive avoidance methods "step down" and "step through") Rhodiola extract in the dose used (0.10 ml per rat) had no substantial effect on learning and memory (a certain deterioration of the training process was even observed using the "shuttle-box" method, while the "step-down" method resulted in deterioration of the memory). The great significance of the method used for studying the effects of the pharmacological agen
ts on learning and memory for the results obtained is evident.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3751623&dopt=Citation

Contribution of the opioid system to realization of inotropic effects of Rhodiola rosea extracts in ischemic and reperfusion heart damage in vitro]

[Article in Russian]

Lishmanov IuB, Naumova AV, Afanas'ev SA, Maslov LN.

It has been established that a course of oral administration of Rhodiola rosea extract in a dose of 3.5 mg/kg prevents reperfusion decrease in contraction amplitude of the isolated perfused rat heart. It also prevents reduction of coronary flow and development of contracture in the postischemic period. Intravenous infusion of naloxone (0.5 mg/kg) completely abolishes the favorable effect of Rhodiola in relation to the heart contractility and coronary flow parameters. The protective effect of Rhodiola may probably be connected with increase in the level of endogenous opioid peptides.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9324395&dopt=Citation

The cardioprotective and antiadrenergic activity of an extract of Rhodiola rosea in stress]

[Article in Russian]

Maslova LV, Kondrat'ev BIu, Maslov LN, Lishmanov IuB.

The course of administration of Rhodiola rosea extract was studied for effects on the pattern of stress-induced cardiac damage which was assessed by 99mTc-pyrophosphate accumulation in the heart. Rhodiola rosea was found to prevent stress-induced cardiac damage. Simultaneously, myocardial catecholamines and cAMP levels were measured. Rhodiola rosea was ascertained to prevent both stress-induced catecholamine release and higher cAMP levels in the myocardium. Moreover, the adaptogen prevented lower adrenal catecholamines during stress. The findings suggest that the antistressor and cardioprotective effects of Rhodiola rosea are associated with limited adrenergic effect on the heart.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7756969&dopt=Citation

[The participation of the mu-, delta- and kappa-opioid receptors in the realization of the anti-arrhythmia effect of Rhodiola rosea]

[Article in Russian]

Maimeskulova LA, Maslov LN, Lishmanov IuB, Krasnov EA.

A course of the adaptogen extractum Rhodiola rosea (3.5 ml/kg given per os daily for 8 days). produces am antiarrhythmic effect on models of epinephrine-induced arrhythmia. Blockade of mu-opiate receptors (OR) by naloxone (0.2 mg/kg) and delta-OR by ICI 174.864 (2.5 mg/kg) had no effect on the resistance of the heart of rats adapted to epinephrine. Higher doses of naloxone reduced significantly the antiarrhythmic effect of extr. Rhodiola. The antiarrhythmic effect of the extract is assumed to be related to activation of the opioid system and stimulation of kappa-OR.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9162281&dopt=Citation

Небольшая монография есть хим формула одного из компонентов
http://www.thorne.com/altmedrev/.fulltext/7/5/421.pdf

Как можете обратить внимание все статьи русских авторов , буду очень благодарен если кто нибудь найдет это же (полный текст)на русском.
Статей очень много буду выкладывать еще если найду

Если найду (есть в продаже в аптеках 30 мл экстракт стоимость если верить интернету от 13 до 18 рублей) то напишу биотест Smile
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