Hydrochlorides are in general sparingly or very sparingly soluble in cold acetone.
Have you spelled this generic name correctly? See if you can find the proper name for this antihistamine and perhaps someone will help you. You might also try the Merk Index for solubility data,
Martindale Pharmacopeia gives the following solubility data:
Quote:
1 in 2 of water
1 in 1.5 to 1.8 of alcohol
1 in less than 1 of chloroform
1 in 2000 of ether
Acetone data is not listed but my guess would be that the salt is freely soluble in it as well since the freebase form is such a non-polar cmpd. I don't have first-hand experience with triprolidine but having recrystallised dextromethorphan HCl, I've found it to be soluble in acetone very well.
In any case, I think of particular interest is CHCl3 as it dissolves pfed HCl only sparingly (1 in 60 to 90), so a chloroform wash should practically eliminate any traces of the antihistamine (just make sure you don't use too much )
If you don't have chloroform, use DCM; they're usually equivalent. (My experiments suggest pfed HCl solubility in DCM as 1 in 100+)
Forums
Rhodium
The Hive
Shop
Profile
Log in
Register
Log in to check your private messages
4061
)