synthetikal.com Forum Index


Built by the Community for the Community
 Forum IndexForums 
 
   Rhodium Chemistry ArchiveRhodium   The ArcHiveThe Hive   Shop   ProfileProfile   Log inLog in   RegisterRegister 
DMT+tryptamine+tryptophan=dangerous?
Page 1 of 1
Post new topic   Reply to topic    synthetikal.com Forum Index -> Pharmacology
Author Message
brain
Linguist Extraordinaire
Joined: 08 Mar 2005
Posts: 143
2405.16 Points
View Single Post4468
DMT+tryptamine+tryptophan=dangerous?

 Fri May 06, 2005 1:09 am		 Reply with quote
hm, i'm wonderin- if this mixture [whih can be obtained from methylation tryptamine with HCHO-synthesised tfrom tryptophan] - when smokeing - can it be dangerous??
Back to top
IndoleAmine
Dreamreader Deluxe
Joined: 09 Feb 2005
Posts: 681
Location: Bahamas
18717.10 Points
View Single Post4469

 Fri May 06, 2005 1:31 am		 Reply with quote
DMT+tryptamine=yes (tryptamine is a lower amine than DMT, so its a MAOI)
Not dangerous, but harder.

BTW methylation will give quaternary trimethyltryptammonium salt, you have to selectively demethylate it again to dimethyl-..
Back to top
brain
Linguist Extraordinaire
Joined: 08 Mar 2005
Posts: 143
2405.16 Points
View Single Post4474

 Fri May 06, 2005 2:23 am		 Reply with quote
demethylate with ~NaBH4 - i know that Smile but slii dont know the temperature, 15 or -15C .... [or mabey you was thinkin on some different method - demethylation?]
Back to top
Star-light
Blacklight bulb
Joined: 26 Mar 2005
Posts: 77
2681.50 Points
View Single Post4483

 Fri May 06, 2005 2:10 pm		 Reply with quote
IndoleAmine wrote:
BTW methylation will give quaternary trimethyltryptammonium salt, you have to selectively demethylate it again to dimethyl-..


HCHO reductive methylation will not give a quaternary trimethylammonium salt. This applies to methylation with CH3I.

As to the temperature, sorry I don't know Brain. There have been doubts expressed about whether the reaction will work with NaBH4 anyway.

There is one report of success using this method but it is unverified. I am also unable to track it down.

You will need to purify your tryptamine before methylating it. Your question above seems to imply that you expect to end up with some kind of soup. Unless you purify things properly during the process, I wouldn't consider smoking it if I were you (even if it were legal).

There are some suggested methods for separating DMT from NMT and tryptamine in the following document.

https://www.synthetikal.com/Rhodiums_pdfs/chemistry/dmtsyn.txt

I have no personal experience of these methods however, so I can't vouch for them.

You may also find the decarboxylation of tryptophan does not go as smoothly as you would hope. I have heard of more than one researcher that has had problems with this reaction.
Back to top
brain
Linguist Extraordinaire
Joined: 08 Mar 2005
Posts: 143
2405.16 Points
View Single Post4495

 Fri May 06, 2005 11:21 pm		 Reply with quote
oh, well, i hope i will hawe tomorrow tryptophane [only 5g Sad ] - i will test it, maybe i will make some pictures,

-i can puryfy dmt on TLC, but then i will hawe to make samples TLC of pure tryptamine and tryptophan - only then i can know-ehwre is dmt [to show indole-compouds i will use DAB - 1% solution).
Back to top
IndoleAmine
Dreamreader Deluxe
Joined: 09 Feb 2005
Posts: 681
Location: Bahamas
18717.10 Points
View Single Post4502

 Sat May 07, 2005 4:10 am		 Reply with quote
I didn't know you were planning to use NaBH4/HCHO, it must be run as cold as possible to reduce the imine before cyclization can occur..

Thanks for clarification Starlight! I really thought MeI methylation...
(btw IIRC one successful but doubted report by someone from hyperlab called "dimitri", and a discussion in the old hive threads where rhodium and others had a couple refs about subbed tryptamines being successfully methylated with boro. If this helps in any way.. Wink )
Back to top
tom-a-rom-rinbow

Joined: 17 Apr 2005
Posts: 15
628.86 Points
View Single Post4513

 Sat May 07, 2005 7:14 am		 Reply with quote
I think the successful report involved adding two reagents simultaneously and in proportion with each other..
Back to top
brain
Linguist Extraordinaire
Joined: 08 Mar 2005
Posts: 143
2405.16 Points
View Single Post4532

 Sat May 07, 2005 1:30 pm		 Reply with quote
adding together... then HCHO - wont hawe hance to react with tryptamine! will be hydrogenated imidietly to CH3OH....
Back to top
Display posts from previous:   
Post new topic   Reply to topic    synthetikal.com Forum Index -> Pharmacology All times are GMT + 5.5 Hours
Page 1 of 1

 



Powered by phpBB 2.0.11 © 2001, 2002 phpBB Group

Igloo Theme Version 1.0 :: Created By: Andrew Charron