Methylated Lysergamides

mk-1 · Tue May 10, 2005 2:47 am

Dear bees!
I know all the ppl have been saying that methylated ergot peptides/lyergamides cannot be used for LSD synthesis, and I agree with that (although that it may be possible, it is hard and i believe low yielding).
But methylated LSD (dubbed MLD-41, i think) is active at 100-300microgram dose, albeit lesser visuals then lsd-25 (according to shulgin). This would also make MLD-41 legal, except under the analog act.
This opens up new froentiers since it is much easier to get methylated ergots then non methylated ergots.
if anyone got comments, it would be appreciated, if not, then see this as just some more useful information passed on this site Very Happy

BTW, as a side note, one lysergamide, dubbed methylergometrine, even though the name suggests it is methylated at N-1 position, it is not. it is methylated after the amide, making it possible to hydrolize to lysergic acid.... some food for thought Very Happy

mk-1 · Tue May 17, 2005 5:39 pm

It appears that Methylergometrine (which is not methylated at the N-1) is a direct metabolite of Methysergide (which is methylated at the N-1). So maybe it is possible to extract the enzyme that does this and use it to demethylate methysergide, and other methylated ergolines...
If anyone has any info bout it, it would be greatly appreciated if he would share it!