Solvent for 2,5-DMA

[GammaQ]

What other solvent can I use to synthesis the 2,5-DMA besides the CHCl3 ??

RGDS !

[Barium]

You need to specify which route you are planning to use, otherwise it´s kinda hard to know which solvents are useful.

[Rhodium]

Instead of using the messy preparation from Pihkal requiring solvent extraction to synthesize the 2,5-dimethoxynitropropene, instead use the procedure at

https://www.thevespiary.org/rhodium/Rhodium/chemistry/edda.html

which gives an equal yield, higher purity, and also produces the 2,5-dimethoxynitropropene in crystalline form directly.

If you still feel you want to use the Pihkal procedure, you can substitute the chloroform with dichloromethane.