isomerzation of safrole not required?

[Glacial_Refluxer]

This wacker oxidation calls for "safrole"

https://www.thevespiary.org/rhodium/Rhodium/chemistry/wacker.krv.html

Would running distilled safrole oil through a wacker
oxidation yeild mdp2p?

What exactly is the reason for isomerizing safrole?

[Rhodium]

Would running distilled safrole oil through a wacker oxidation yeild mdp2p?

Yes.

What exactly is the reason for isomerizing safrole?

To create isosafrole, which is the required starting material for synthesizing MDP2P through for example peracid oxidation.

Different routes demands different starting materials.