synthesis of a selective noradrenaline RI

[mysterious]

hi bees,

can anyone post a link to the synthesis of a selective noradrenaline reuptake inhibitor?
do you know if there is a rapid onset of them or if one has to wait for weeks like with the SSRIs??

thanks a lot

mysterious

[thallium]

Pharmacology:

http://www.ijmt.net/3_4/3_4_26.html

http://www.chemi-tek.com/ver_news.asp?cod_assunto=35

Reboxetine synthesis:

Patent US4229449

Patent US5068433

Patent US5391735