The poison is in the dose.

Never tried strychnine myself, of course, but there is history of using it as a stimulant and tonic, I have medical manuals from the late 1800s, granted they still reccomended using mercury and chalk as a baby teething powder, and their remedy for piles was to burn them off with HNO3, but strychnine isn't so bad, IF it is not in a toxic dose.

Too much water will kill through hyponatraemia, likewise, too much strychnine will drop you dead in a pretty godawful way, but less than a fatal dose, less still than a damaging dose, has indeed been used quite safely, medically.

Also, a strychnine containing seed (known as camalonga, by the curanderos who specialise in its use, although there is more than one plant known as camalonga) is used shamanically without lethality.

He did specifically inform that it was potentially lethal if too much was taken, warned of toxicity from lesser doses, then specifically specified a very low dose only, was to be potentially taken.

Quite different I personally believe, from advising morons to say, test to see if a DMSO solution of KCN was hot enough.

At those sorts of doses, I would be interested to try strychnine actually, or perhaps the less toxic brucine.

A small dose of gelsemium tincture (gelsemine is a glycine agonist, although toxic in larger doses than should be taken) would reverse toxic effects if need be, in an emergency or if severe, although that too is a potentially lethal paralytic agent if too much is used, glycine also would likely help ameliorate milder side effects, since strychnine is a glycine receptor antagonist, and I believe although high affinity, it is competitive (I.e an allosteric blocker)

Strychnine IS a notorious poison, but the dose alone make it so, like I say, too much water and you die, and I myself have taken up to 3-4 mg of huperzine-A, if I had taken that the first time I took it, given a starting active dose is 50-100 micrograms I would have been quite seriously ill, it is a cholinesterase inhibitor, a nerve agent, just like sarin or VX, or carbamate insecticides, although unlike those, reversible, yet after becoming used to it, and ramping up the dose slowly, I didn't die, I did not experience lachrymatory effects, nor nausea or the shits, or sweating, all I noticed, in the way of side effects were upon the pupil of the eye, and a slight to moderate lowering of the heart rate, whilst getting the cognitive boost and reversal of memory loss that I was wanting out of its use.

Act like a moron around a potent neurotoxin, you will get fucked in the arse with a sharp stick, act with respect and you will not, short of tragic accidents, just look at that guy who dipped his tongue in a baggie of 2C-T-7 (or it might have been 2C-T-4 I do not remember) instead of weighing a dose, what happened? the guy died, or that poor bastard who railed a whomping line of DOB in mistake for MDxx, again, he got fucked.

Wikipedia, granted not the perfect font of information, lists the LD:50 as 10mg/kg

And I believe the report of the guy overdosing, used a tincture, possibly of a plant source? not so prescise as measuring out weight on a milligram scale.

As active medically used doses are typically used between 1/60th grain and 1/10th grain (one grain was equal to 60mg) and the LD:50 is around 10mg/kg, that is quite a difference. (formerly used, that is, I do not believe strychnine is actually used in human medicine in western countries any more? or is it?)

And a 'full dose' was usually, according to my books, 2-3mg, rarely more than 5-6mg.

At a single milligram, or two, or even three, I would try it myself, if I had a source hanging around, which at the moment, I do not.

A homeopathic dose is NO dose.

I would cheerfully sit and drink two liters of the strongest homeopathic remedy available containing arsenic, strychnine, hell, if they made a homeopathic 'remedy' with a mixture of chelonitoxin, maitotoxin, batrachotoxin, palytoxin and HCN all in the same water, I would drink a liter  or three without hesitation, as long as I could throw in enough salts in there to prevent hyponatraemia and some cool-aid packets so it tasted of something other than water.

A homeopathic remedy, is equivalent to the assumption that one is currently drinking trilobite piss, due to the fact that when they roamed the deep ocean trenches, they must have excreted somehow, and then that sea must have had some evaporate, come down as rain a thousand millenia ago, and now I drink it in my morning cup of green tea with eucalyptus honey.

hmmm and a 60 billion a year industry to boot.
i've also tried nux vomica seed it's about 1.3% strychnine and the rest is brucine.
it was'nt too bad either.
btw be real careful with that if you grind the powder the dust can kill you if you inhale it.
a dose of that would be about 100 mg of the seed powder it's bitter as hell.
you do feel a tightness in the chest and in the spine.
but it's very slight at a small dose like that.
i like the sensory enhancement i'm pretty sure some of the acid back in the 90's had strychnine because i know that taste.
 the blue sunshines and the onks (however you spell that) were bitter as fuck and it gave you this tension in the back so i know it was strychnine.


here they speak i'll of it's toxic properties but also mention "there is no impairment of sensory or cognitive function."
and also mention the fixed grin which is exactly what i noticed about those specific blends of lsd was the permagrin i used to call it.
intersting

http://www.portfolio.mvm.ed.ac.uk/studentwebs/session2/group12/strychni.htm

A dose of strychnine, even a safe, stimulant dose, is far too large to get on a blotter. You're lucky to get 5 milligrams of anything onto your typical blotter tab. Stimulation could be more easily explained by substitution with DOI, which is quite stimulating -- but there was plenty of real acid in the '90s thanks to the heroic effords of Dr. William Leonard Pickard.

http://www.portfolio.mvm.ed.ac.uk/studentwebs/session2/group12/strychni.htm

here is a thread where someone describes thier expirience with strychnine.

https://www.dmt-nexus.com/forum/framehelper.aspx?g=posts&t=5695&p=2

Neither of these are valid sources when speaking of taking poisons. What that guy on Nexus was talking about sounds like a load of BS and his information is less valid then all. There have been test in the past of LSD for strychnine yet never a reported case that I am aware of yet Im suppose to(and you are!!!!) take his word for it that there really is strychnine in LSD?

Yes it can be taken but there is LITTLE evidence that it should be taken.


Then there are things said like this that bug me the most about these sort of discussions and show why I dislike hearing them. Because the general public drug user is a moron....

Besides, it enhances all those aspects of LSD, that set's LSD apart from the other psychedelic's. It will make your LSD more LSD-like!
The only side effect i've noticed is that it will shorten your attention span somewhat. You will be less able to focus on one thing because you will be more easily distracted by all the visual and other sensations happening in and around you, then with just plain LSD.

This dipshit really said it will make your LSD more LSD like...... REALLY... because I thought the LSD was LSD like and that strychnine was more like convulse your back till your feet touch your head like. Face it people there are most people that should not take drugs and should spend most of there life working for the man because they are safer and more protected from themselfs that way.

I am having serious concerns about Piracetam because I have begun regiment start and stop twice now and both times I have gotten a cold sore... I do not know why this is and perhaps its a fluke but I worry that it is interfearing with my immune system somehow and even though I love the subtle effects of it im unsure if I can continue.

Has anyone else noticed this? I never get cold sores so two times within a few days of starting to take them seems odd.

Sunifiram looks really interesting.

I am just waiting to bag some propionyl chloride, found a source just have to save up until I can afford some, benzoic anhydride after that, should be cheap and not, as far as I know, suspicious.

The AMPAkines as a whole, look on paper, amazing, AMPA potentiation allosterically, either by slowing inactivation of the open channel state (ala barbs at GABAa), or reducing time spent in the desensitised state, both of the above, and possibly some may increase open frequency (ala benzos at GABAa)

AMPA receptor is critical for NMDA receptor expulsion of the cationic voltage dependent blockade, increasing learning and memory, also should help the survival of newly formed neurones and synaptic connections, not sure if sunifiram in particular does this, but many, if not most AMPAkines act as BDNF releasers.

One other potential drug is a modification of melatonin, N-acetylserotonin (which is just 5HT with a bare hydroxyl, unshielded by the methyl ether of 5HT itself.

Think conc. HBr would cleave that ether nice and neat like, without fucking with the amide? if not of course, a suitable protecting group for the amide shouldn't be a problem.

Start with melatonin, cleave ether with HBr (protect if needs be), if it properly bioavailable, then it acts as a TrkB receptor agonist, and a potent one at that, could be a bioavailable way to imitate BDNF as a growth factor, and I just BET it would make a good nootropic with longterm effects.

Or if it like 5HT itself is not going to pass the BBB, the phenolic hydroxyl could be shielded as a group much more labile than a methyl ether, how about an ester? perhaps a sterically hindered ester which would undergo relatively slower cleavage than say, the ethyl or propyl ester, tert-butyl maybe, or perhaps more interestingly, a long chain fatty acid such as arachidonic acid with potential endocannabinoid properties, or at least CB-ergic modulation somehow.

Think its worth attempting somehow? the chemistry is easy after all, and melatonin is cheap, a few hundred milligrams to a gram wouldn't cost much.

Melatonin and serotonin are NOT TrkB agonists!

And the arachidonic acid ester idea was merely to provide a long chain ester that could withstand degradation to a degree that wouldn't get it instantly buttfucked once taken, and one that is not unhealthy, after all, arachidonic acid plays a part in neurotransmission, and cannabinergic activity, it wasn't MEANT to get you high, maybe some incidental pain relieving or antianxiety properties, but really just there to deliver N-acetylserotonin into the brain without being restricted to the PNS.

Amitryptyline? how potent is it at TrkB, compared to N-Ac5HT or to BDNF itself, I want to know binding affinity, agonistic efficacy and if possible dissociation constant.

Anybody know if TrkB is a receptor which is capable of expressing functional selectivity towards different ligands, with corresponding different intracellular pathways? is it a G-protein coupled receptor, if so what G proteins are associated with it, do they change with tolerance? does tolerance even occur?

And does TrkB desensitise or downregulate under prolonged agonist application? that would really suck shit for a nootropic, and indeed just for the poor bastard taking it and becoming a synthetic BDNF ligand addict haha.

Stop and your brain slowly rots until you got yourself dementia and you drown in your own slobber and shit. Nice.

You just told a large amount of in some cases down right idiots to eat Strychnine.

Let the record show Sedit believes we are down right idiots

BDNF action is fucking complicated, that much is certain. Very finely tuned system.

I have been curious about amitryptiline though, of course its likely to make one dumb as frozen shite for a while of not taken with nootropics of some sort due to the antimuscarinic activity, but I wonder if it could be taken for a period of time and produce lasting effects?

I have some here actually.