They appear to only sell magnesium supplements as magnesium oxide with other binding agents. Can anyone think of how I might be able to safely convert that into a salt that is more likely to pass the blood brain barier? Perhaps reacting it with glutamic acid, or glutamine to form an amino salt of magnesium - which might work sort of like the magnesium-L-threonate?

Careful,

Magnesium sulphate treatment decreases blood-brain barrier permeability during acute hypertension in pregnant rats.

Euser AG, Bullinger L, Cipolla MJ.

University of Vermont, Department of Neurology, 89 Beaumont Avenue, Given C454, Burlington, VT 05405, USA.

Someone please retrieve this if possible


Abstract

Eclampsia is associated with increased blood-brain barrier (BBB) permeability and formation of cerebral oedema. Magnesium sulphate is used to treat eclampsia despite an unclear mechanism of action. This study was to determine the effect of magnesium sulphate on in vivo BBB permeability and formation of cerebral oedema during acute hypertension and on brain aquaporin-4 (AQP4) protein expression. An in vivo model of hypertensive encephalopathy was used in late-pregnant (LP) rats following magnesium sulphate treatment, 270 mg kg(-1) i.p. injection every 4 h for 24 h. Permeability of the BBB was determined by in situ brain perfusion of Evan's Blue (EB) and sodium fluorescein (NaFl), and dye clearance determined by fluorescence spectrophotometry. Cerebral oedema was determined following acute hypertension by measuring brain water content. The effect of magnesium treatment on AQP4 expression was determined by Western blot analysis. Acute hypertension with autoregulatory breakthrough increased BBB permeability to EB in both brain regions studied (P < 0.05). Magnesium attenuated BBB permeability to EB during acute hypertension by 41% in the posterior cerebrum (P < 0.05) but had no effect in the anterior cerebrum (P > 0.05). Treatment with magnesium did not change NaFl permeability, cerebral oedema formation or AQP4 expression. In summary, BBB permeability to Evan's Blue was increased by acute hypertension in LP rats, and this was attenuated by treatment with magnesium sulphate. The greatest effect on BBB permeability to EB was in the posterior cerebrum, an area particularly susceptible to oedema formation during eclampsia.

Link: http://www.ncbi.nlm.nih.gov/pubmed/17933863


But no need to fear because correct use of it and we get a decrease in NMDA receptors and an overall sedating effect which could pose helpful to an overworked brain.

Brain and CSF magnesium concentrations during magnesium deficit in animals and humans: neurological symptoms.


Im going to continue to be a google hero now because its something that has interested me for a while but I have never taking it further then theory.

Magnesium sulphate treatment decreases blood-brain barrier permeability during acute hypertension in pregnant rats.

Euser AG, Bullinger L, Cipolla MJ.


Abstract:
Eclampsia is associated with increased blood-brain barrier (BBB) permeability and formation of cerebral oedema. Magnesium sulphate is used to treat eclampsia despite an unclear mechanism of action. This study was to determine the effect of magnesium sulphate on in vivo BBB permeability and formation of cerebral oedema during acute hypertension and on brain aquaporin-4 (AQP4) protein expression. An in vivo model of hypertensive encephalopathy was used in late-pregnant (LP) rats following magnesium sulphate treatment, 270 mg kg(-1) i.p. injection every 4 h for 24 h. Permeability of the BBB was determined by in situ brain perfusion of Evan's Blue (EB) and sodium fluorescein (NaFl), and dye clearance determined by fluorescence spectrophotometry. Cerebral oedema was determined following acute hypertension by measuring brain water content. The effect of magnesium treatment on AQP4 expression was determined by Western blot analysis. Acute hypertension with autoregulatory breakthrough increased BBB permeability to EB in both brain regions studied (P < 0.05). Magnesium attenuated BBB permeability to EB during acute hypertension by 41% in the posterior cerebrum (P < 0.05) but had no effect in the anterior cerebrum (P > 0.05). Treatment with magnesium did not change NaFl permeability, cerebral oedema formation or AQP4 expression. In summary, BBB permeability to Evan's Blue was increased by acute hypertension in LP rats, and this was attenuated by treatment with magnesium sulphate. The greatest effect on BBB permeability to EB was in the posterior cerebrum, an area particularly susceptible to oedema formation during eclampsia.

Does anybody have any experience with ergoloid mesylates and any other ergoloid analogs? Ergoloid mesylates was developed by Albert Hofmann and is prescribed for myoclonus  as well as being  used to relieve the signs and symptoms of decreased mental capacity due to the aging process. It stimulates dopaminergic and serotonergic receptors and blocks alpha-adrenoreceptors. However, the mechanism of action is still unknown.
 The recommended dosage is roughly 3 mg a day .  It may be used with other nootropics like Piracetam, with which it is synergistic.

Why is appetite suppression a bad thing?

It doesn't mean you can't eat, just that you might not feel as inclined to. Just remember to eat and you'll be fine.

Would be a relaxant most likely via its action on strychnine-sensitive glycine receptors and improve cognition via binding to the glycine co-agonist site on the NMDAr complex.

What's your source on this?

Oh the day that drugs that make you smarter become regulated will be a grand day, if it ever happens.

I don't think it is available in the same way in which it needs to be though...

I always take my magnesium supplement with a V8 since I think it might help its availability and ability into passing the BBB in the correct and safe way. It probably does neither.

I would like to see a reference that strychnine has any nootropic effects. It might just make you feel as though it did.