Hey,

Is there any factible reaction to do that??

I'm really interested in phencyclidine and that is worth a try if it can be done!

Thank you!

Sure it is possible, but ... Synthetic construction of PCP would be a far more simple route, than to produce the 4-methoxy analog and go back to the base compound ... even if making for solely experimental reasons to try the route and procedure.

Perhaps This would help, as a first step in that direction.

The picture was taken from Chinese paper,

Demethylating Reaction of Methyl Ethers
ZHANG Jin-mei  LI Yue-qing  ZHAO Wei-jie*
(State Key Laboratory of Fine Chemicals ,Dalian University of Technology,Dalian  116012?China)

Which cites,

[8] FREDRIKSSON A, SHARON SE ? Rapid
microwave-assisted cleavage of methyl Phenyl
ethers:new Method for synthesizing desmethyl
precursors and for removing protecting groups.

--
Here is that paper hxxp://finechem.dlut.edu.cn/05icfm/article/review/Demethylating%20Reaction%20of%20Methyl%20Ethers.pdf

It's demythelation of an aromatic ether, in this case it is a methoxy group so it does look relevant doesn't it. Granted it's not the most user friendy procedure it is exactly what you asked for! The removal of the aromatic alcohol should be well documented.

That seems the most likely path. Only experimentation will tell. One would have to understand the mechanism in this and see are there other functional groups which are likely to bee affected.



As an aside is 4-MeO-PCP not active? Is the 4-OH-PCP ?

4-methoxy-PCP is definitely active. Tsathoggua just tested it for the first time today actually.
4-OH-PCP is likely to possess greater affinity for the mu opioid receptors than the ether counterpart. Same goes for 3-MeO-PCP and 3-OH-PCP. These two are MUCH more potent than the 4-substituted compounds. And in both cases, a bare hydroxyl group lends the arylcyclohexylamine in question greater affinity for MOR.

Reflux in constant-boiling HBr should cleave the ether, then you are left with a phenolic OH, which perhaps, could be halogenated, then the halo-derivative dehalogenated with Pd/C and H2 under pressure.

Would this bee a viable route to phencyclidine? The ether cleavage should bee the easy bit

The aromatic dehalogenation though....

Would LAH do the trick?

Toady too would like to try phencyclidin, PCP is pretty much non-existent in this country, having looked for years, it simply does not seem to be available, at all, for any price.

Toady believes it largely an american thing. smoking sherm sticks, having bullets bounce off you, and eating policemen having first skinned them alive with their own teeth, like a caveman using a flint hand axe...thats yank cultural heritage that is.

The procedure that Tshatoggua gives it's very hard and expensive I think, its more worth making the PCP itself which isn't difficult and precursors arent heavily watched.

But is there any cheap way to convert 4-methoxyphencyclidine into phencyclidine without using HBr concentred, Pd/C and that things?

I will look more into this.

Thank you

I'm very high on 3-MeO-PCP right now, it's beautifull!!!


But i have 10g of 4-MeO-PCP right here , it's worth it to do that two reactions?

thank you.

I looked that pdf a while back.

I dont want to make PCP with the bucket method or whatever.

I just want to demethoxylate 4-MeO-PCP to give PCP in easy terms.

Thank you.

I dont want to make PCP with the bucket method or whatever.

I just want to demethoxylate 4-MeO-PCP to give PCP in easy terms.

There seems to be some sort of difficulty in communicating the facts of organic synthesis in this thread    You have ten grams of a compound that you have described as beautiful  Several members have taken the time to explain that your request is rather unlikely to be worth the resources needed in reagents and equipment considering how much easier it is to simply synthesize phencyclidine using a known procedure    A review of dealkylation procedures  is attached    You may be able to reduce the phenolic hydroxyl group to hydrogen by distilling from zinc dust or refluxing in hydriotic acid, but either method could also fail miserably    It also may be possible to halogenate the phenol and then reduce the halogen as Tsathoggua already said  There's no published article describing exactly how to do the conversion you're interested in, and the chances of something going wrong in the series of reactions needed is more than you apparently think it is This thread is a waste of a lot of time since you're not very knowledgeable in organic synthesis but expect the membership to figure it out for you  This community is a gift culture, the question is what have you contributed that justifies your expectations in starting this thread    This topic has already been reported to the staff and could be locked and/or moved to Vacuous Posts for being futile