I've been reading through a number of articles on MPTP, but practically all of them focus on the mechanism through which it causes Parkinson's symptoms with only casual mention of it's formation during MPPP synthesis.
I'm trying to understand the mechanism and conditions under which it forms in order to be sure synthesis of its analogues is avoided during modifications to loperamide and other compounds of similar structure. My understanding so far is that the intermediate alcohol is unstable except at low temperatures and correct pH levels, and dehydrates to the toxic MPTP when it destabilizes. If this is the case, then there should be no concern when working with loperamide or other compounds which are already stable at room temperature, but I would like to see some sort of lterature to back this up.
I will continue to look and post anything I find. Does anyone else have more detailed references?
I'm trying to understand the mechanism and conditions under which it forms in order to be sure synthesis of its analogues is avoided during modifications to loperamide and other compounds of similar structure. My understanding so far is that the intermediate alcohol is unstable except at low temperatures and correct pH levels, and dehydrates to the toxic MPTP when it destabilizes. If this is the case, then there should be no concern when working with loperamide or other compounds which are already stable at room temperature, but I would like to see some sort of lterature to back this up.
I will continue to look and post anything I find. Does anyone else have more detailed references?