Author Topic: Tramadol  (Read 426 times)

Oerlikon

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Tramadol
« on: August 22, 2010, 11:54:31 PM »
I found no specific thread on this substance so I decided to make it a thread.

For some this drug is almost nothing ,for others...whoa!

It helped me go over morphine addiction I earned in hospital and I noticed something else with this
drug unlike other opiate.

200-250mg is whole day eperience, makes me unbelievably sociable and talkative, speedy and just utterly happy.
Tramadol "trip" is pretty long and complex experience.
Ranging from euphoric happy and speedy at the beginning to the calm and relaxing, than utterly happy again and than
super satisfied and calm that melts into sleep that is more nodding than real sleep.
On other opiates you just go slow and nodding after initial euphoria.
I dontuse it more than once a month or so to avoid addiction.

What is your experience with this drug?!

I know it mangles in some ways with serotonin, but most drugs doo, but this one is pretty unique!
« Last Edit: May 17, 2011, 12:11:14 AM by Oerlikon »
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Tsathoggua

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Re: Tramadol
« Reply #1 on: August 23, 2010, 02:31:50 AM »
Tramadol has additional serotonergic and noradrenergic reuptake inhibitor effects, not just 5HTergic-icity.

I hate the stuff personally.
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Oerlikon

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Re: Tramadol
« Reply #2 on: August 23, 2010, 06:35:28 PM »
Why exactly?!
It has only minor side-efects like constipation and hard time pissing.
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jon

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Re: Tramadol
« Reply #3 on: August 25, 2010, 08:06:18 AM »
it's due to the the distance twist the nitogrogen atome and the benzen once  a synthethis was was attepted to yeild a phenylperidine type heterocycle and the result was a 1,3 phenyloxazine well the benzine ring or in your case not constrained allowing it co0sser contact with the nitrogen (tert as in cocaine) the result was a stimulant similar to cocaine

















salat

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Re: Tramadol
« Reply #4 on: August 26, 2010, 02:44:42 AM »
I think they gave me some when a dog bit off part of my lip and it wasn't as bad as opiates.  Opiates really make me feel sick.  But I didn't get high off it.  Could have just been feeling a bit bummed about the state of my lip and the idiots at the hospital who call themselves and ER. 

salat
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Sedit

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Re: Tramadol
« Reply #5 on: August 26, 2010, 03:19:30 AM »
We have another thread lables tramadol for opiate withdrawl. Perhaps this is better suited for that don't you think?

We strive to keep our seach engine from experiancing overload, so if anything can be contained in an existing thread it would be easier on the moderators and the search engine if it where placed where it can be found with ease.
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Oerlikon

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Re: Tramadol
« Reply #6 on: August 26, 2010, 06:27:11 PM »
Oh,sorry...I didn't realized that.

I thought it is interesting subject, since different people have drastically different
reaction on this substance. Opiate withdrawal is just one of it's benefits.

Feel free to combine this with mentioned thread.

Anyway, I find this substance to be something like "super-drug", like made just for myself.
It is great combination of upper and downer, effects are strong but totally controllable,
and you can function completely normal. It has special "magic" to it and lasts over 12h!
To make it even better it is very cheap and side-effects are slim to none if you don't doo it
too often.
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Oerlikon

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Re: Tramadol
« Reply #7 on: December 04, 2010, 03:06:38 AM »
I discovered something simple yet amazing...

After my Tramadol source run low I decided to take 50mg of Dimenhydrinate with 70-80% of my average dose of Tramadol.
IT WAS AMAZING!!!

There was heavy nod and oncosious "body melting"/OBE experience.
Experience is much more like real-deal opiates and less speedy than pure Tram
and nods are much more stoning(nothingness) than trippy as ussual.

Sleep was great,effects lasting full 24h (lets say that last 6h were kind'a afterglow.)
and depression that follows few days after 5-HT system stimulation was lower than usual.

P.S.:Drug containing 10mg of Codeine phosphate was also taken for mild flue few hours before
but I doubt it is so important for experience.
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OoBYCoO

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Re: Tramadol
« Reply #8 on: December 04, 2010, 05:47:44 AM »
This drug did nothing for me.

Oerlikon

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Re: Tramadol
« Reply #9 on: December 04, 2010, 04:05:53 PM »
What does did you took!?
It's afascinating thing,either you love it or you hate it.
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Vespula germanica

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Re: Tramadol
« Reply #10 on: December 04, 2010, 05:56:57 PM »
200 mg are GREAT stuff. I have difficulties to understand how people can not like it, but of course tastes are always different. Above that 200 mg light cramps were apparent especially in the legs. That provided an easy way to determine the upper limiting dose. I never went further.
...bzzzzzz...

OoBYCoO

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Re: Tramadol
« Reply #11 on: December 04, 2010, 06:06:37 PM »
I don't remember what dose, but I know it was high b/c I used to pop a bunch of them in my mouth b/c I never got anything out of them.

Oerlikon

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Re: Tramadol
« Reply #12 on: December 04, 2010, 06:26:17 PM »
200mg quick relase (dissolved in water) to 240mg(normal pills) is best dose for me.
Now after I dicovered Tramadol+Dimenhydrinate combo it's ball's to the wall awsome!!!

It's not about taste,no one cannot-like it! It probably doesn't work for other people that way.
But that's better in my opinoin,since it won't be abused and more controled too soon. :-)
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Vespula germanica

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Re: Tramadol
« Reply #13 on: December 04, 2010, 10:00:39 PM »
I should have pointed out that I tried Tramadol as solution (40 drops = ca. 100 mg)
...bzzzzzz...

Oerlikon

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Re: Tramadol
« Reply #14 on: December 05, 2010, 02:30:13 AM »
Only!? For a stoning "trip"!? I envy you!
You must be midget or have very very lucky metabolism! :-)
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Sedit

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Re: Tramadol
« Reply #15 on: December 05, 2010, 03:41:23 AM »
Tramadol imho Sucks, but that is ust my take on it and everyone has different metabolisms and neurobiology.

So since we are in the Pharmacology area of this forum does anyone wish to fill us in on the kinetics of how this substance behaves in the body.

I understand its metabolite M1 is the active opiate but I don't understand the serotonin aspects of the drug which IMHO cause it to suck. But that's just me. 
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Oerlikon

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Re: Tramadol
« Reply #16 on: December 05, 2010, 02:37:17 PM »
It sounds like very complex acting supstance with multiple active metabolites that act on different receptors.
So my humble gess is that stuff is differently broken down in body of somebody who loves it and someone who hates it.

It even depends from one dose to another,speed of release and other things you take.

Smaller doses acts quite speedy and makes you socializable (noticeable antidepressant activity!)

Sometimes(when you take too large dose and/or slow release) it takes hours to kick in,and then acts
very shortly in the good euphoric manner and than rest of the experience is filled with extreme intolerance(even hate)
of touch and presence of other people,and sometimes it is just opposite!
But it is allways good to sit down,do nothing and listen some music.(very nice!)

In most cease and "perfect" dose is taken you are just numb(very desirable when you need to sit for 6-7h in one place),
everything you think about is just nice and perfect and you can choose to nod(quite trippy),but you can choose to be
are fully aware of surrounding and can act normally.
I discovered it solely for this purpose,since I need to endure long and uncomfortable travels every month or so.

Combination with Dimenhydrinate I "discovered" has no speedy effects at all,it acts like real deal opiate,
you go into perfect secure bubble and everything is foggy and distant around you,no thing can bother you!

All in all,it is quite fascinating stuff,there is some pattern but you newer know what you will get,like Harry Potter Bertie Bott's Jelly Beans :-)

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Vespula germanica

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Re: Tramadol
« Reply #17 on: December 05, 2010, 07:15:35 PM »
Only!? For a stoning "trip"!? I envy you!
You must be midget or have very very lucky metabolism! :-)

Maybe you confused it. The "40 drops = ca. 100 mL" described only the way of determining the approx. dose. I usually used 200 mg taken at once per single session. And YES, that was enough to get Tramadol-stoned.

So since we are in the Pharmacology area of this forum does anyone wish to fill us in on the kinetics of how this substance behaves in the body.

Try to get a copy of:
Journal of Pharmacology and Experimental Therapeutics 2003, 305: 710
Journal of Pharmacology and Experimental Therapeutics 2000, 293: 646
These 2 publications contain almost everything you need to know about tramadol's pharmacokinetics.
...bzzzzzz...

jon

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Re: Tramadol
« Reply #18 on: December 06, 2010, 08:13:35 PM »
well over at SM there is some discussion of using thiophenol anion hence the sodium salt to demethylate the compound a common high boiling thiol would be thioglycolic acid and it would'nt really matter that it is slightly zwtterionic because it would be done using it's base pair thiolate demethylations might be what the doctor ordered and if you look at the molecule another thing that could be done would be to esterify it with propionic anhydride that would make it more akin to the reversed esters of demerol possibly change it's pharcology a bit.
that would be a nice research chemical because it's not an analoge of CI or CII hence not illegal and probably a lot safer that some of the other opiates so it could be sold without fear of reprecussions like fatal overdoses which can bring the wrath of the government upon one's pate.
one of the reasons you don't see "research opiates" being sold is because opiates are among the most controlled drugs worldwide because of thier potential for fatalities which is'nt a sustainable business practice.
unless you have a license. 

Sedit

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Re: Tramadol
« Reply #19 on: December 07, 2010, 06:40:57 AM »

So since we are in the Pharmacology area of this forum does anyone wish to fill us in on the kinetics of how this substance behaves in the body.
Quote

Try to get a copy of:
Journal of Pharmacology and Experimental Therapeutics 2003, 305: 710
Journal of Pharmacology and Experimental Therapeutics 2000, 293: 646
These 2 publications contain almost everything you need to know about tramadol's pharmacokinetics.

Na Id rather not since honestly I could careless, my main point is if you are going to post in a pharmacology section of the forum make it just that. Dont make it a place just to post trip reports from pills.......
There once were some bees and you took all there stuff!
You pissed off the wasp now enough is enough!!!