Author Topic: kitchen-tek cocaine analog? 3-psuedotropyl-ortho-hydrox/acetoxy-tropane  (Read 717 times)

t8er

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Re: kitchen-tek cocaine analog? 3-psuedotropyl-ortho-hydrox/acetoxy-tropane
« Reply #40 on: September 20, 2010, 05:09:10 AM »
anybody pulled there atropine from datura or nightshade ??

where i am is covered in night shade :)

and from what ive been reading and researching it should not be to much to get it out either

im flat out at the moment but bit later will zip up and post all the pdf's and tid bits ive been reading there sorta all over the place in my archives atm, but i suspect most people will have the same material

take care
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Vesp

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Re: kitchen-tek cocaine analog? 3-psuedotropyl-ortho-hydrox/acetoxy-tropane
« Reply #41 on: September 20, 2010, 05:20:28 AM »
Quote
anybody pulled there atropine from datura or nightshade ??

Sort of.. yes. I did a water extraction from Datura Inoxia with a bit of acid or something probably and the goop which I intended too purify later evaporated into having long sharp but dirty crystals mixed in with the waxes, tannins, and other junk. It lookeds really easy to continue it into a nice pure tropane alkaloid crystals but I had tossed it.

Atropa Belladona I believe is a much better source than datura. I'd like to obtain a large quantity of viable seeds from that plant. It is a bit tricky to locate when you live hundreds of miles from where it grows :P


PS. - are you sure it is atropa belladona you are looking at, or some other nightshade, perhaps?
« Last Edit: September 20, 2010, 05:36:43 AM by Vesp »
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t8er

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Re: kitchen-tek cocaine analog? 3-psuedotropyl-ortho-hydrox/acetoxy-tropane
« Reply #42 on: September 20, 2010, 05:41:29 AM »
awesome that's good to hear that vesp  :)

where i is there is a lot of potato farms about everywhere and the shit grows like fucking wild fire in those areas,

where i moved out of every year the back yard around the compost heap used to go mental with nightshade,

they have eradication procedures round here to try and get rid of the stuff lol (good luck)

ahhhh i gotta get stuff done and i just keep reading and posting lol

take care
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hypnos

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Re: kitchen-tek cocaine analog? 3-psuedotropyl-ortho-hydrox/acetoxy-tropane
« Reply #43 on: September 20, 2010, 06:31:35 AM »
Lol :D kitchen-tek cocaine analogue! nice try...who knows?

as for tomatoes and the other members of the 'nightshade' family........re; the bits we're interested in...

Alkaloids

Solanaceae are known for possessing a diverse range of alkaloids. As far as humans are concerned, these alkaloids can be desirable, toxic, or both.

One of the most important groups of these compounds is called the tropane alkaloids. The term "tropane" comes from a genus in which they are found, Atropa (the belladonna genus). The belladonna genus is so named after the Greek God of Fate, Atropos, who cut the thread of life. This nomenclature signifies the toxicity and lethality that has long been known to be characteristic of these compounds.

Tropane alkaloids are also found in the Datura, Mandragora, and Brugmansia genera, as well as many others in the Solanaceae family.[3] Chemically, the molecules of these compounds have a characteristic bicyclic structure and include atropine, scopolamine, and hyoscyamine. Pharmacologically, they are the most powerful known anticholinergics in existence, meaning they inhibit the neurological signals transmitted by the endogenous neurotransmitter, acetylcholine. Symptoms of overdose may include dry mouth, dilated pupils, ataxia, urinary retention, hallucinations, convulsions, coma, and death.

Despite the extreme toxicity of the tropanes, they are useful drugs when administered in extremely small dosages. They can reverse cholinergic poisoning, which can be caused by overexposure to pesticides and chemical warfare agents such as sarin and VX. More commonly, they can halt many types of allergic reactions. Scopolamine, a commonly used ophthamological agent, dilates the pupils and thus facilitates examination of the interior of the eye. They can also be used as antiemetics in people prone to motion sickness or receiving chemotherapy. Atropine has a stimulant effect on the central nervous system and heart, whereas scopolamine has a sedative effect.

An infamous alkaloid from the Solanaceae family is nicotine. Like the tropanes, its pharmacology acts on cholinergic neurons, but with the opposite effect (it is an agonist as opposed to an antagonist). It has a higher specificity for nicotinic acetylcholine receptors than other ACh proteins. Its effects are well known[clarification needed]. Nicotine occurs naturally in the Nicotiana or Tobacco genus.

Another class of toxic substances found in this family are the glycoalkaloids, for example solanine which has occasionally been responsible for poisonings, in people who ate berries from species such as Solanum nigrum or Solanum dulcamara, or green potatoes.[4][5]

The chemical in chili peppers responsible for the burning sensation is capsaicin. Capsaicin affects only mammals, not birds. Pepper seeds can always survive the digestive tract of birds; their fruit becomes brightly colored once its seeds are mature enough to germinate thereby attracting the attention of birds who then 'distribute' the seeds. Capsaicin extract is used to make pepper spray, a useful deterrent against aggressive mammals.

Courtesy of wiki....

oops I read this thread backwards, accidentally..of course :-[
« Last Edit: September 20, 2010, 06:58:08 AM by hypnos »
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t8er

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Re: kitchen-tek cocaine analog? 3-psuedotropyl-ortho-hydrox/acetoxy-tropane
« Reply #44 on: October 02, 2010, 12:22:19 PM »
Hope this can be some use to some body :)

Extraction of two medicinally active compounds from plant sources

Abstract


Asiaticoside (the ester of the triterpene asiatic acid) and madecassoside (the ester glycoside of the triterpene madecassic acid) are the chief medicinally active compounds of the plant Centella asiatica ("Mandukparni") of the family Apiaceae. These were successfully extracted through column chromatography along with saponin fraction

The alkaloid atropine, used extensively as a muscle relaxant, especially during eye surgery, was extracted from common jimson weed - Datura Stramonium o the family Solanaceae. On commercial scale, the compound is normally obtained from another plant of the family- Atropa belladona. Here, we report the extraction procedure for atropine from Datura as perfected by us.




« Last Edit: October 02, 2010, 12:24:53 PM by t8er »
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thallium

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Re: kitchen-tek cocaine analog? 3-psuedotropyl-ortho-hydrox/acetoxy-tropane
« Reply #45 on: February 03, 2011, 08:42:03 PM »
What's the best way to isolate tropine after hydrolyzing atropine in NaOH (aq)? It's freely soluble in both water and alcohol :P

atara

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Re: kitchen-tek cocaine analog? 3-psuedotropyl-ortho-hydrox/acetoxy-tropane
« Reply #46 on: February 04, 2011, 05:05:12 AM »
Tropine freebase, but not sodium tropate (atropine hydrolyses to tropine and tropic acid), should be freely soluble in diethyl ether, so heating to boil away as much water as possible and extracting with ether would be my first guess.

The utility of this depends, of course, on how clean your atropine was and on how thorough the hydrolysis was.
« Last Edit: February 04, 2011, 05:07:09 AM by atara »

thallium

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Re: kitchen-tek cocaine analog? 3-psuedotropyl-ortho-hydrox/acetoxy-tropane
« Reply #47 on: February 04, 2011, 10:48:21 AM »
The atropine sulphate should be reasonably pure, it's pharmaceutical grade from the 50ies, if anything I guess it may contain some tropinone... Incomplete hydrolysis is obviously a possible problem, I'm not a big fan of atropine delirium, but refluxing in lye for several hours should hopefully do the trick?

Maybe lefetamine from l-alanine and benzaldehyde would be a better project, my lab skills after all these years are bound to be rusty.