this...could...be...awesome  

http://en.wikipedia.org/wiki/Salicylmethylecgonine  < 10x in vitro ~3x stronger in mice than cocaine
http://en.wikipedia.org/wiki/3-%28p-Fluorobenzoyloxy%29tropane < 70% weaker

extraction and hydrolysis of atropine
extraction of tropine
Fischer-Speier esterification with 2-acetoxybenzoic acid or salicylic acid

end produkt
3-pseudotropyl-ortho-acetoxybenzoate / Salicyl-3-tropane

Seeing as this is such an amazingly simple compound to produce, hopefully it has good effects
I'm curious to see the difference in the one made with aspirin and the one made with salicylic acid and i'm really hoping that the ortho-hydroxy makes up for the potency compared to the 4-fluorotropacocaine.

you drew that wrong but are you talking about saliciloyl cocaine?

i've always wondered how that stuff was?
how is the high?
i mean something that tickles the yay g-spot 10 times more effective than coke has to be fun.

NaBH4, why did you bother with salicylic chloride when you could have just done a Fischer-Speier esterification?
Have you tried the esterification of tropine/3-tropanol with salicylic acid?
Also what is the best way to re-crystallize the Saliciloyl Tropacocaine and how would you rate potency compared to cocaine?
Doing the esterification what is the ratio you would use and what acid for catalyst?

Interesting, coke never gave me much euphoria to begin with, just an obnoxious frat boy type ego. Could you do a quick write up for the fischer-speier esterification, I know i will need more weight in tropine than salicylic acid but im just not worth shit when it comes to accurate math.

Nor-saliciloyltropacocaine ?
Yeap, that's a good idea 

I'm actually trying to put that goddamn propanoyl group but i'll try to N-demethylate my Saliciloyl tropacocaine next week 

i don't know about doing a fisher esterification on that because you want to pervent the beta hydroxy group from epimierizing correct?

it is'nt as "fun" as cocaine???

Naphyrone, I want to put a propanoyl group and not a carbomethoxy group on that goddamn tropinone ^__^
I think propionic chloride will do that if the 3rd position (3=O) is protected.

Jon, Salicyl-tropacocaine is fun but that's definitaly not cocaine. It certainly better than street cocaine but not as good as good grade cocaine


@Naphyrone :
For the salicylic analogue of tropacocaine, I started with pure Tropinone (bought in china uh uh) because I didn't manage to get my hand on a selective extraction protocol of datura or nightshade.

But you're right : What the well could do the Scopolamine version of this compound ? oO

How much does succindialdehyde run for and is it watched? Because tropine that iv'e sourced is expensive and i'm not sure if I want to work with large quantities of anticholinergics. I mean the thought of having to move around 500+ml of datura/brugmansia alkaloid extract kinda scares me :'(.

Thank you wolfram alpha for telling me about the properties of atropine and scopolamine...

Scopolamine:
molecular weight | 303.353 g/mol
phase | solid  (at STP)
melting point | 59 °C

experimental LogP hydrophobicity | 0.8
predicted LogP hydrophobicity | 1.4
predicted LogS | -1.66
experimental Caco2 permeability | -4.93

Atropine:
molecular weight | 289.369 g/mol
phase | solid  (at STP)
melting point | 115 °C
boiling point | 393 °C

experimental LogP hydrophobicity | 1.8
predicted LogP hydrophobicity | 2.19
experimental LogS | -2.12
predicted LogS | -2.06

This should help with separation after extraction   (i love the internet)

Would one be able to use a long chain alcohol say, cetyl alcohol to separate the atropine from scopolamine effectively?
My idea is take the alkaloid salts, put them in cetyl alcohol thats been heated to 51*C, the scopolamine is heavier than the alcohol thus should sink to the bottom in theory.
Scoop out the atropine salt then with a clean batch of the cetyl alcohol heat it to 62*C to melt any scopolamine that is hanging onto the atropine salts, stir, let sit at this temp.
Scoop out the atropine salts once again, let them cool off, dissolve in seperatory funnel with water. Shake, then let any cetyl alcohol separate from the water. (Recrystalize atropine???) Move to hydrolysis process.