Author Topic: MMDA  (Read 820 times)

Methyl Man

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Re: MMDA
« Reply #20 on: April 13, 2011, 12:15:57 AM »
Neil, I have wondered the very same thing a number of times. It's almost as if MMDA and DMMDA et al had their moment in the sun in the 70s (I think it was, the Claudio Naranjo research, right?) and are now arcane and unhip or something. Yet, a couple of them do sound very interesting indeed. Maybe it (MMDMA) is destined for a "comeback." You could even say that MDMA made a comeback after 70 years or so of obscurity.
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akcom

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Re: MMDA
« Reply #21 on: April 13, 2011, 03:51:32 AM »
What is the legal status of those analogues?  I took a brief search but didn't find anything.  Are they just covered under the analogue act? 

DopeBee

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Re: MMDA
« Reply #22 on: April 13, 2011, 04:26:14 AM »
i find it strange that nobody recommends any of the other essential oils that seem to be able to follow suite and directly plug into any safrole synth as well to reach their amphetamine derivatives also, essential oils like myristicin, apiole, dillapiole to name a few.
I can almost guarantee it is because of their availability in the past. The precursors to PMA were plentiful and easy to get in their pure form whereas myristicin, apiole and dillapiole as you quoted yourself "there's no telling with myristicin content of parsley oil, it's just a crapshoot it seems." Of course in many foreign countries the average income is still hovering around a dollar a day, so sourcing 99% myristicin is easier than ever.

What is the legal status of those analogues?  I took a brief search but didn't find anything.  Are they just covered under the analogue act?
I wonder if everything simply falls under the analogue act in the USA now? In Canada they still list every banned substance individually. MDA, MDMA, MMDA, STP all fall under schedule 3 here.

RoidRage

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Re: MMDA
« Reply #23 on: April 13, 2011, 04:40:25 AM »
In Canada they still list every banned substance individually. MDA, MDMA, MMDA, STP all fall under schedule 3 here.

Off-topic, but I've read somewhere (RCMP website If I'm not mistaken) that they want to transfer the MDxx to Schedule I as part of their  anti-synthetic drug crusade. For what it's worth...

akcom

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Re: MMDA
« Reply #24 on: April 13, 2011, 05:06:53 AM »
Quote
MMDA is classified as a Schedule 1 substance in the United States, and is similarly controlled in other parts of the world. Internationally, MMDA is a Schedule I drug under the Convention on Psychotropic Substances[1]
No idea what these international agreements actually imply

DopeBee

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Re: MMDA
« Reply #25 on: April 13, 2011, 05:08:42 AM »
Off-topic, but I've read somewhere (RCMP website If I'm not mistaken) that they want to transfer the MDxx to Schedule I as part of their  anti-synthetic drug crusade. For what it's worth...
That's because schedule 1 carries a maximum life sentence for production, whereas schedule 3 carries a maximum 18 month sentence. Just another example of idiots making laws and experts being ignored.

EDIT: Oops yah you're right it's max 10 years. Fucked up.
« Last Edit: April 13, 2011, 05:15:04 AM by DopeBee »

fractal

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Re: MMDA
« Reply #26 on: April 13, 2011, 05:09:26 AM »
MMDA is schedule 1 in the US, others would be covered under the analogue act.

RoidRage

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Re: MMDA
« Reply #27 on: April 13, 2011, 05:12:37 AM »
Off-topic, but I've read somewhere (RCMP website If I'm not mistaken) that they want to transfer the MDxx to Schedule I as part of their  anti-synthetic drug crusade. For what it's worth...
That's because schedule 1 carries a maximum life sentence for production, whereas schedule 3 carries a maximum 18 month sentence. Just another example of idiots making laws and experts being ignored.

Are you sure about that ? I've got court documents here about people getting sentenced to 48 months in federal prison for producing MDA. Pretty sure maximum for producing Schedule III Compounds is 10 years. That kind of discussion is more relevant to Law&Security than this thread though :D

NeilPatrickHarris

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Re: MMDA
« Reply #28 on: April 13, 2011, 06:42:28 PM »
Yet, a couple of them do sound very interesting indeed. Maybe it (MMDMA) is destined for a "comeback."

the methylated compounds (DMMDMA, DMMDMA-2, MMDMA, TMMA-2) are all almost inactive.  there are posts by antibody2 and chromic on the hive about them assaying those 4 compounds and basically just felt a buzz at upwards of a couple hundred milligrams.  some exceptions to that rule are MDMA and PMMA which are both very active of course.

based on what i've read it sounds like MMDA and DMMDA are both very worthwhile.  DMMDA-2 is interesting but sounds too stimulating for my preferences.  just as an update i finally tried 2c-b after over a decade of searching.  2c-b ended up being everything i wanted it to be, it was fun/euphoric/visual all while being soft on the ego.  but i'm still as interested as ever to try MMDA and DMMDA some day.  antibody2 was gracious enough to grace us with his presence over in the "MDOH vs MDA" thread and verified he used performic as the route to get to the ketone when he was experimenting with MMDA/DMMDA/DMMDA-2.  sounds simple enough thanks to his experimentation and pioneering into these exotic phenethylamines :)

Sedit

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Re: MMDA
« Reply #29 on: April 13, 2011, 07:04:50 PM »
The "inactivity" of these compounds is what always intrieged me about them. Sure its not for the hard core roller but I have found around 25 Mg per day of MDMA to be very benificial to the mind and body. The only side effects noted where rapid hair and finger nail growth and flactuance but other then that a weaker compound with simular pharmacological action could be of great value to many here.
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akcom

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Re: MMDA
« Reply #30 on: April 13, 2011, 11:37:39 PM »
Are you sure about that ? I've got court documents here about people getting sentenced to 48 months in federal prison for producing MDA. Pretty sure maximum for producing Schedule III Compounds is 10 years. That kind of discussion is more relevant to Law&Security than this thread though :D
How many people did they rat on?

Sedit

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Re: MMDA
« Reply #31 on: April 14, 2011, 12:34:00 AM »
I have known people to get busted and they do much less time then that mostly time served and probationary sentances. It seems like a common misconception that your in for life if you get caught making Ecstacy. I don't know what qualifys to make you do a large amount of time but I have seen much less then 2 years on a couple occassions even when they didn't rat anyone out.
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RoidRage

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Re: MMDA
« Reply #32 on: April 14, 2011, 02:41:45 AM »

How many people did they rat on?

I'm talking about Canada, so I found thoses sentences pretty harsh actually...Was surprised they got so much...Never though it was possible

jon

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Re: MMDA
« Reply #33 on: April 14, 2011, 07:10:42 AM »
this thread has taken on a life of it's own but peracids and highly substituted propenyl benzene are a no go the ring is too highly activated and this carbocation is formed that is very stable.
the result is cyclization to a weird looking tertahydrofuran
there is an article on rhodium entitled 'why asarone can't be oxidized with a peracid' paraphrased and it shows the mechanism.
the carbocation is forned when the pinacol rearrangement is underway.
this does not negate the possibility of lithium iodide rearragement of epoxides that might circumvent this problem

i would'nt waste my time with it.
the journals use the nitroalkene.
any allybenzene should react the  same with hydrobromic acid that's likely a good cross the board route for most of these oddballs.
2,5 dmmda sounds like the best thing since sliced bread, as antibody describes it.
« Last Edit: April 14, 2011, 07:20:05 AM by jon »

myCH3

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Re: MMDA
« Reply #34 on: May 23, 2013, 09:35:45 AM »
Sorry to dig up an old thread but I am trying to puzzle this thing out and would like some help from someone more knowledgeable

I think that jon's bromination probably works,but then I saw this:
http://chestofbooks.com/health/aromatherapy/The-Volatile-Oils-Vol1/Myristicin.html

In short,in reaction with Br2 it gives dibrommyristicindibromide and
this compound has m.p. of 130°C,that means it might be isolated from mixture of
oils w/o distillation but I am not smart enough to figure out exact route!

Other info on this page might be handy to someone with more skill and knowledge!

I keep just finding that same exact line With bromine it yields dibrommyristicindibromide m.p. 130 http://archive.org/stream/volatileoils024539mbp /volatileoils024539mbp_djvu.txt   I've seen it like 12 places yet none of them state where they found it and I can't find any papers referencing that happening where are both the bromines being added anyways?  Is it something like this attached image?  I'm not sure of if I should trust this as on this sight http://www.epharmacognosy.com/2012/05/phenol-volatile-oils-anethole-safrole.html  it says that apiole when brominated will give three things and that safrole when brominated will give pentabromosafrole?  which would go in the face of the bromosafrole route and wasn't that the original from like the way back? 

*fixed drawing
« Last Edit: May 23, 2013, 03:11:33 PM by myCH3 »

lugh

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Re: MMDA
« Reply #35 on: May 23, 2013, 10:11:14 AM »
Studying this page might bee helpful:

http://www.erowid.org/archive/rhodium/chemistry/mdp2p.dibromide.html

in solving that puzzle and learning more ;)  The end results from the effort applied  8)
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antibody2

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Re: MMDA
« Reply #36 on: May 23, 2013, 02:40:43 PM »
2,5 dmmda sounds like the best thing since sliced bread, as antibody describes it.

It is! The most interesting amphetamine Ab2 has ever encountered. Ab2 will probably run that synth again sometime soon. To reiterate, apiole is a major constituent of parsley seed oil, although it requires a long tedious fractional distillation. Most oil suppliers can give you a GC MS analysis of their oils so it isn't a crapshoot really. iso-Apiole survives a peracid rxn no problem.

DMMDA2 working up from dill apiole (dillapiole is commercially available requiring little purification) was a little trickier , not in the peracid step, but in the reduction of the oxime and salt formation. THF was used as the solvent for the reduction. Getting a solid salt from the post reaction work-up was always an issue. The only success was in forming the sulfate, attempts to gas with dry HCl resulted in an amber syrup in the bottom of the flask. At the time this was assumed to have been a cyclized  product, but thinking back perhaps it was simply taking its time to crystallize. It was discarded without having been bioassayed. In retrospect possibly a mistake.

DMMDMA2 was not active.

myCH3

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Re: MMDA
« Reply #37 on: May 23, 2013, 03:18:41 PM »
Studying this page might bee helpful:

http://www.erowid.org/archive/rhodium/chemistry/mdp2p.dibromide.html

in solving that puzzle and learning more ;)  The end results from the effort applied  8)

Thank you very much that answered alot of questions but added some new ones, first would this be the correct mechanism for what is going on here (attached file)?  and I take it this is not correct when it gives the brominated results for apiole (they labled dillapiole as apiole actually) safrole and myristicin? 

Antibody2 am I correct in believing you went:  from the allylbenzene to the iso to the ketone to the oxime then reduced to the amine? 


antibody2

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Re: MMDA
« Reply #39 on: May 23, 2013, 06:43:15 PM »
Antibody2 am I correct in believing you went:  from the allylbenzene to the iso to the ketone to the oxime then reduced to the amine? 

Yes, exactly, in all cases, MMDA, DMMDA and DMMDA2.